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№ 6 (2015)
- Жылы: 2015
- Мақалалар: 12
- URL: https://journals.eco-vector.com/2073-4034/issue/view/6928
Articles
H. PYLORI-INFEKTsIYa: SOVREMENNYE REKOMENDATsII PO DIAGNOSTIKE I LEChENIYu
Аннотация
The article describes the basic approach to the treatment of H. pylori-infection in accordance with Maastricht recommendations. The main indicators characterizing the effectiveness of treatment are suggested. The tactics of treatment in case of resistance to the components of the conventional therapy is discussed in detail. The criteria, which are sufficient for H. pylori eradication to prevent gastric cancer, are proposed. The need to find the simple and reliable methods for determining the of H. pylori sensitivity to antibiotics without a biopsy of the gastric mucosa is emphasized.
Pharmateca. 2015;(6):6-10
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TAKTIKA VEDENIYa BOL'NYKh GASTROEZOFAGEAL'NOY REFLYuKSNOY BOLEZN'Yu S VNEPIShchEVODNYMI SINDROMAMI
Аннотация
The article presents the substantiation of the relationship of laryngitis, chronic cough and asthma with gastroesophageal reflux disease. An approach to the diagnosis of extraesophageal syndromes is considered. The evidence base and an algorithm for the treatment of extraesophageal manifestations of gastroesophageal reflux disease are analyzed and discussed.
Pharmateca. 2015;(6):11-14
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KOGNITIVNYY I NEYROPLASTIChESKIY POTENTsIAL VITAMINA D U DETEY I PODROSTKOV
Аннотация
Over the past 10 years, fundamental and clinical studies have established a little-known role of vitamin D in the development and functioning of the central nervous system. The article presents the results of a systematic analysis of more than 2,000 studies of neurotrophic and neuroprotective effects of vitamin D, and relationships between vitamin D deficiency, reduction of learning ability, memory disorders in children and adolescents, alexithymia, and the risk of early stroke and the risk of demyelinating diseases (amyotrophic lateral sclerosis) at a young age. It is shown that the use of vitamin D for recovery after traumatic brain injury, in paroxysmal vertigo and epilepsy is justified.
Pharmateca. 2015;(6):15-24
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BOL' V GLOTKE: PRIChINY VOZNIKNOVENIYa I SPOSOBY LEChENIYa
Аннотация
This review considers the basic pathogenetic processes characteristic of inflammation in the throat. Attention is directed to the inappropriate, in most cases, the use of systemic anti-inflammatory drugs for the treatment of pharyngitis. The main reasons include a wide range of adverse effects and delayed anti-inflammatory action. The above reasons make a choice in favor of topical agents as most optimal. Mechanism of anti-inflammatory action of flurbiprofen is discussed in detail. The results of modern multicenter, randomized studies showing the efficacy and safety of this drug in the treatment of pharyngitis are presented.
Pharmateca. 2015;(6):25-29
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METITsILLINREZISTENTNYE ZOLOTISTYE STAFILOKOKKI: PROBLEMA RASPROSTRANENIYa V MIRE I ROSSII
Аннотация
Methicillin-resistant Staphylococcus aureus (MRSA) are the leading causative agents of nosocomial infections; they were first described in 1961 in England, and now are spreading worldwide. The most important feature of MRSA is resistance to most в-lactam antibiotics, as well as the high incidence of associated resistance to antibiotics of other groups. Of particular concern is the emergence and spread of MRSA with reduced susceptibility to vancomycin and isolates resistant to daptomycin, linezolid, tigecycline and ceftaroline. Isolates with reduced susceptibility to these drugs are already registered in the Russian Federation. This review summarizes recent data on the expantion, antibiotic resistance, and molecular epidemiology of MRSA. The modern pharmacotherapies for the treatment and prospects of therapy of MRSA-infections are discussed.
Pharmateca. 2015;(6):30-38
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POZhILOY BOL'NOY OSTRYM I KhRONIChESKIM BRONKhITOM: KLYuChEVYE VOPROSY ANTIBAKTERIAL'NOY TERAPII
Аннотация
The article considers the features of antibiotic treatment in elderly patients with acute bronchitis or exacerbation of chronic bronchitis. Principles for selecting the most appropriate antibacterial drugs (ABD) are presented; special attention is paid to the safety of antibiotic therapy. It is emphasized that safety of ABD in this specified group of patients can be achieved by taking into account the specific clinical situation, the functions of the kidneys and liver, pharmacodynamic and pharmacokinetic properties of the drug, correction of dose of ABD appointed (creatinine clearance), and careful clinical and laboratory monitoring of the treatment process.
Pharmateca. 2015;(6):39-45
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TRUDNYY BOL'NOY - PATsIENT S ChASTYMI RETsIDIVIRUYuShchIMI ZABOLEVANIYaMI RESPIRATORNOGO TRAKTA
Аннотация
In patients with frequent catarrhal diseases, it is necessary to exclude serious pathology. In most cases, the appointment of immunomodulatory therapy in patients with recurrent respiratory diseases is not justified. For this group of patients, it is necessary to minimize the pharmacological impact using rehabilitation. Patients with uncontrolled allergic respiratory diseases (allergic rhinitis and bronchial asthma) are predisposed to acute respiratory diseases, acute respiratory viral infections and complications such as sinusitis and bronchitis. In case of detection of immunodeficiency states mediated by chronic persistent viral infection, administration of antiviral therapy with double action (inosine pranobex - Isoprinosine) would be appropriate. Inhibition of replication of persistent viral infections in these patients leads to restoration of immune function and reduces the frequency of relapses.
Pharmateca. 2015;(6):46-49
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PROGNOSTIChESKAYa ROL' MARKEROV SISTEMY PROTEOLIZA U BOL'NYKh YaZVENNYM KOLITOM
Аннотация
This article discusses the clinical and pathogenetic role of proteolysis system components (matrix metalloproteinase 9 and tissue inhibitor of matrix metalloproteinase-1) in the colonic mucosa of patients with ulcerative colitis, and provides criteria for prediction of relapse and remission of the disease, allowing to complement modern diagnostic and treatment algorithm, and limit the use of steroid hormones.
Pharmateca. 2015;(6):50-53
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SOVREMENNYE PATOGENETIChESKIE PODKhODY K LEChENIYu SINDROMA RAZDRAZhENNOGO KIShEChNIKA - ZALOG KLINIChESKOY EFFEKTIVNOSTI
Аннотация
The article presents the results of the 5-year follow-up of 52 patients with irritable bowel syndrome (IBS) in outpatient settings. Patients were managed by gastroenterologist (32 patients) and therapists (20 patients). It was noted that management of patients by gastroenterologist significantly reduces the hospitalization rate and length of stay on sick leave compared with management by therapists, also providing the better quality of life for patients.
Pharmateca. 2015;(6):54-59
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PRINTsIPY RATsIONAL'NOY PERIOPERATIVNOY FARMAKOTERAPII PATsIENTOV S VROZhDENYMI POROKAMI SERDTsA, OSLOZhNENNYMI LEGOChNOY GIPERTENZIEY
Аннотация
In patients with congenital heart disease complicated by pulmonary hypertension (PH), phosphodiesterase type 5 inhibitors of (PDEI-5) in combination with of angiotensin-converting enzyme (ACE) inhibitors were used in the preoperative period; this combination contribute to vasodilation of the vessels of pulmonary circulation and thus reduce the pressure in the pulmonary artery by 8-14%. Postoperatively, combination of PDEI-5, ACE inhibitors and infusion of PDEI-3, cardiotonic drugs, prostaglandin E1 reduces the residual pressure in the pulmonary circulation, reduces the frequency of complications, prevents of occurrence of pulmonary hypertensive crises and stabilizes hemodynamics in the early postoperative period.
Pharmateca. 2015;(6):60-63
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DIAGNOSTIKA I LEChENIE TYaZhELOY VNEBOL'NIChNOY PNEVMONII U VZROSLYKh: OSNOVNYE POLOZhENIYa
Аннотация
Severe community-acquired pneumonia (SCAP) is a special form of the disease, which is characterized by high mortality and high health care costs. Given the high frequency of diagnostic errors in SCAP in Russia and the widespread practice of irrational use of medicines, guidelines for practitioners have been developed; the adherence to these guidelines will contribute to improving treatment outcomes in persons with SCAP aged 18 years and older. This publication contains the main statements of clinical practice guidelines for the diagnosis and treatment of adult patients with SCAP.
Pharmateca. 2015;(6):64-75
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