Vliyanie na endokannabioidnye sistemy: odin iz vozmozhnykh mekhanizmov deystviya nimesulida
- Autores: Kotova O.V1
-
Afiliações:
- Edição: Nº 20 (2012)
- Páginas: 30-32
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/280140
- ID: 280140
Citar
Texto integral
Acesso aberto
Acesso está concedido
Acesso é pago ou somente para assinantes
Resumo
The benefits of selective cyclooxygenase-2 (COX-2) inhibitors in the treatment of acute and chronic pain syndromes include the following: significantly fewer adverse events associated with the gastrointestinal tract, kidney, liver; no negative effect on the synthesis of the major components of articular cartilage as contrasted with nonselective NSAIDs. Nimesulide (Nise) in therapeutic doses is a selective reversible competitive COX-2 inhibitor. NSAIDs implement analgesic effect via endocannabinoid system, apart from the traditional well-known pathways. Nimesulide affects the cannabinoid receptors type 1 without affecting anandamide or 2-arachidonoyl glycerol.
Texto integral
Bibliografia
- Насонов Е.Л., Лазебник Л.Б., Беленков Ю.Н. и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М., 2006. 88 с.
- Mastbergen SC, Bijlsma JWJ, et al. Synthesis and release of human cartilage matrix proteoglycan are differently regulated by nutric oxide and prostaglandine-E2. Ann Rheum Dis 2008;67:52-8.
- Garcia-Nieto B, Perez C, Checa A, Gago F Molecular model of the interaction between nimesulide and human cyclooxygenase-2. Rheumatology 1999;38:14-8.
- Shan AA, Murray FE, Fitzgerald DJ. The in vivo assessment of nimesulide cyclooxigenase selectivity. Rheumatology 1999;38:19-23.
- Kerola M, Vuolteenaho K, Kosonen O, et al. Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo. Basic Clin Pharmacol Toxicol 2009;104:17-21.
- Raicford K Current satus of the therapeutic uses and actions of the preferential cyclooxigenase-2 NSAID, nimesulide. Inflamopharmacol 2006; 14:120-3 7.
- Bennet A. Nimesulide a well established cyclooxygenase-2 inhibitor with many oher pharmacological properties to inflammatory diseases. In: Therapeutic roles of selective COX-2 inhibitors. Ed. Vein JR, Botting RM. William Harvey Press 2001:524-40.
- Rainsford K. Nimesulide - a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med Res Opin 2006; 22(6):1161-70.
- Erdogan F, Ergun H, et al. The diffusion of nimesulide gel into synovial fluid: a comparison between administration routes. Int J Clin Pharmacol Ther 2006;44(6):270-75.
- Coman OA. Recent data on cannabinoids and their pharmacological implications in neuropathic pain. J Med Life 2008; 1 (4):365-67.
- Huwiler A, Pfeilschifter J. Lipids as targets for novel anti-inflammatory therapies. Pharmacol Ther 2009; 124( 1 ):96-112.
- Guhring H, Hamza M, et al. A role for endocannabinoids in indomethacin-induced spinal antinociception. Eur J Pharmacol 2002; 454:153-63.
- Pertwee RG. Cannabinoid receptors and pain. Prog Neurobiol 2001;63:569-611.
- Deutsch DG, Glaser ST, et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. J Biol Chem 2001; 276:6967-73.
- Kinsey SG, Long JZ, O'Neal, et al. Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. J Pharmacol Exp Ther 2009;330:902-10.
- Palazzo E, de Novellis V, et al. Neuropathic pain and the endocannabinoid system in the dorsal raphe: pharmacological treatment and interactions with the serotonergic system. Eur J Neurosci 2006;24:2011-20.
- Wilson RI, Nicoll RA. Endocannabinoid signaling in the brain. Science 2002;296(5568):678-82.
- Snider NT, Sikora MJ, et al. The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. J Pharmacol Exp Ther 2008;327:538-45.
- Kozak KR, Prusakiewicz JJ, Marnett LJ. Oxidative metabolism of endocannabinoids by COX-2. Curr Pharm Des 2004; 10:659-67.
- Slanina KA, Schweitzer P Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA 1 hippocampus. Neuropharmacology 2005;49:653-59.
- Staniaszek LE, Norris LM. Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids. Br J Pharmacol 2010; 160(3):669-76.
- Fowler CJ, Holt S, Tiger G. Acidic nonsteroidal antiinflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner J Enzyme Inhib Med Chem 2003; 18:55-8.
- Awumey EM, HillSK, Diz DI, Bukoski RD. Cytochrome P450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. Am J Physiol Heart Circ Physiol 2008;294:2363-70.
- Котова О.В. Назначение нестероидных противовоспалительных препаратов: соотношение эффективность/безопасность // Consilium medicum. Приложение Неврология. Ревматология 2012. № 1. С. 79-82.
Arquivos suplementares
