Vliyanie na endokannabioidnye sistemy: odin iz vozmozhnykh mekhanizmov deystviya nimesulida
- Authors: Kotova O.V1
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Affiliations:
- Issue: No 20 (2012)
- Pages: 30-32
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/280140
- ID: 280140
Cite item
Abstract
The benefits of selective cyclooxygenase-2 (COX-2) inhibitors in the treatment of acute and chronic pain syndromes include the following: significantly fewer adverse events associated with the gastrointestinal tract, kidney, liver; no negative effect on the synthesis of the major components of articular cartilage as contrasted with nonselective NSAIDs. Nimesulide (Nise) in therapeutic doses is a selective reversible competitive COX-2 inhibitor. NSAIDs implement analgesic effect via endocannabinoid system, apart from the traditional well-known pathways. Nimesulide affects the cannabinoid receptors type 1 without affecting anandamide or 2-arachidonoyl glycerol.
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