The relationship of cardiovascular disease with increased intestinal permeability: results from scientific and controlled clinical trials. Focus on the potential of rebamipide
- 作者: Ostroumova O.D.1,2, Kochetkov A.I1, Pavleeva E.E3, Golovina O.V1, Arablinsky N.A4
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隶属关系:
- Russian Medical Academy of Continuous Professional Education
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- A.I. Yevdokimov Moscow State University of Medicine and Dentistry
- Pirogov Russian National Research Medical University (Pirogov Medical University)
- 期: 卷 28, 编号 3 (2021)
- 页面: 39-49
- 栏目: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/313101
- DOI: https://doi.org/10.18565/pharmateca.2021.3.39-49
- ID: 313101
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作者简介
Olga Ostroumova
Russian Medical Academy of Continuous Professional Education; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: ostroumova.olga@mail.ru
Dr. Sci. (Med.), Professor, Head of the Department of Therapy and Polymorbid Pathology, Russian Medical Academy of Continuous Professional Education; Professor of the Department of Clinical Pharmacology and Propedeutics of Internal Diseases, I.M. Sechenov First Moscow State Medical University Moscow, Russia
A. Kochetkov
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
E. Pavleeva
A.I. Yevdokimov Moscow State University of Medicine and DentistryMoscow, Russia
O. Golovina
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
N. Arablinsky
Pirogov Russian National Research Medical University (Pirogov Medical University)Moscow, Russia
参考
- Lewis C.V., Taylor W.R. Intestinal barrier dysfunction as a therapeutic target for cardiovascular disease. Am J Physiol Heart Circ Physiol. 2020;319(6):H1227-33. Doi: 10.1152/ ajpheart.00612.2020.
- Fukui H. Increased Intestinal Permeability and Decreased Barrier Function: Does It Really Influence the Risk of Inflammation? Inflamm Intest Dis. 2016;1(3):135-45. doi: 10.1159/000447252.
- Tr0seid M., Andersen G.O., Broch K., Hov J.R. The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions. EBioMedicine. 2020;52:102649. doi: 10.1016/j.ebiom.2020.102649.
- Bischoff S.C., Barbara G., Buurman W., et al. Intestinal permeability - a new target for disease prevention and therapy. BMC. Gastroenterol. 2014;14:189. doi: 10.1186/s12876-014-0189-7.
- Groschwitz K.R., Hogan S.P Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol. 2009;124(1):3-20; quiz 21-2. Doi: 10.1016/j. jaci.2009.05.038.
- Raleigh D.R., Marchiando A.M., Zhang Y., et al. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell. 2010;21(7):1200-13. doi: 10.1091/mbc.e09-08-0734.
- Ulluwishewa D., Anderson R.C., McNabb W.C., et al. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 2011;141(5):769-76. Doi: 10.3945/ jn.110.135657.
- Johansson M.E., Thomsson K.A., Hansson G.C. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. J Proteome Res. 2009;8(7):3549-57. doi: 10.1021/pr9002504.
- Feng Y., Huang Y., Wang Y., et al. Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy. PLoS One. 2019;14(6):e0218384. doi: 10.1371/journal. pone.0218384.
- Li J.Y., Chassaing B., Tyagi A.M., et al. Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J Clin Invest. 2016;126(6):2049-63. Doi: 10.1172/ JCI86062
- Rao R.K., Basuroy S., Rao V.U., et al. Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Biochem J. 2002;368(Pt. 2):471-81. Doi: 10.1042/ BJ20011804.
- Menard S., Cerf-Bensussan N., Heyman M. Multiple facets of intestinal permeability and epithelial handling of dietary antigens. Mucosal Immunol. 2010;3(3):247-59. Doi: 10.1038/ mi.2010.5.
- Spadoni I., Zagato E., Bertocchi A., et al. A gut-vascular barrier controls the systemic dissemination of bacteria. Sci. 2015;350(6262):830-34. doi: 10.1126/science.aad0135.
- Battson M.L., Lee D.M., Li Puma L.C., et al. Gut microbiota regulates cardiac ischemic tolerance and aortic stiffness in obesity. Am J Physiol Heart Circ Physiol. 2019;317(6):H1210-20. doi: 10.1152/ajpheart.00346.2019.
- Sandek A, Swidsinski A., Schroedl W., et al. Intestinal blood flow in patients with chronic heart failure: a link with bacterial growth, gastrointestinal symptoms, and cachexia. J Am Coll Cardiol. 2014;64(11):1092-102. Doi: 10.1016/j. jacc.2014.06.1179.
- Zhou X., Li J., Guo J., et al. Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction. Microbiome. 2018;6(1):66. doi: 10.1186/s40168-018-0441-4.
- Zhang L., Wang F., Wang J., et al. Intestinal fatty acid-binding protein mediates atherosclerotic progress through increasing intestinal inflammation and permeability. J Cell Mol Med. 2020;24(9):5205-12. doi: 10.1111/jcmm.15173.
- Pasini E., Aquilani R., Testa C., et al. Pathogenic Gut Flora in Patients With Chronic Heart Failure. JACC. Heart Fail. 2016;4(3):220-27. Doi: 10.1016/j. jchf.2015.10.009.
- Li C, Gao M., Zhang W., et al. Zonulin Regulates Intestinal Permeability and Facilitates Enteric Bacteria Permeation in Coronary Artery Disease. Sci Rep. 2016;6:29142. doi: 10.1038/srep29142.
- Ghosh S.S., Bie J., Wang J., Ghosh S. Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR-/- mice--role of intestinal permeability and macrophage activation. PLoS One. 2014;9(9):e108577. doi: 10.1371/journal. pone.0108577.
- Li J., Zhao F., Wang Y., et al. Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome. 2017;5(1):14. doi: 10.1186/s40168-016-0222-x.
- Ejtahed H.S., Ardeshirlarijani E., Tabatabaei-Malazy O., et al. Effect of probiotic foods and supplements on blood pressure: a systematic review of meta-analyses studies of controlled trials. J Diab Metab Disord. 2020;19(1):617-23. Doi: 10.1007/ s40200-020-00525-0.
- Kim S., Goel R., Kumar A., et al. Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure. Clin Sci. (Lond). 2018;132(6):701-18. doi: 10.1042/CS20180087.
- Santisteban M.M., Qi Y., Zubcevic J., et al. Hypertension-Linked Pathophysiological Alterations in the Gut. Circ Res. 2017;120(2):312-23. doi: 10.1161/CIRCRESAHA.116.309006.
- Hu J., Luo H., Wang J., Tang W., Lu J., Wu S., Xiong et al. Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice. Exp Mol Med. 2017;49(8):e370. Doi: 10.1038/ emm.2017.122.
- Battson M.L., Lee D.M., Jarrell D.K., et al. Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction. Am J Physiol Endocrinol Metab. 2018;314(5):E468-77. doi: 10.1152/ajpendo.00187.2017.
- Rogler G., Rosano G. The heart and the gut. Eur Heart J. 2014;35(7):426-30. Doi: 10.1093/ eurheartj/eht271.
- Wang Z., Klipfell E., Bennett B.J., et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472(7341):57-63. Doi: 10.1038/ nature09922.
- Konter J.M., Parker J.L., Baez E., et al. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation. J Immunol. 2012;188(2):854-63. doi: 10.4049/jimmunol.1100426.
- Cui L., Zhao T., Hu H., et al. Association Study of Gut Flora in Coronary Heart Disease through High-Throughput Sequencing. Biomed Res Int. 2017;20 1 7:3796359. doi: 10.1155/2017/3796359.
- Jie Z., Xia H., Zhong S.L., et al. The gut microbiome in atherosclerotic cardiovascular disease. Nat Commun. 2017;8(1):845. Doi: 10.1038/ s41467-017-00900-1.
- Zhu Q., Gao R., Zhang Y., et al. Dysbiosis signatures of gut microbiota in coronary artery disease. Physiol Genomics. 2018;50(10):893-903. doi: 10.1152/physiolgenomics.00070.2018.
- Karlsson F.H., Fak F., Nookaew I., et al. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun. 2012;3:1245. doi: 10.1038/ncomms2266.
- Roediger W.E. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterol. 1982;83(2):424-29.
- Marques F.Z., Nelson E., Chu P.Y., et al. High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice. Circulation. 2017;135(10):964-77. doi: 10.1161/CIRCULATIONAHA.116.024545.
- Arutyunov G.E., Kostyukevich O.I., Serov R.A., et al. Collagen accumulation and dysfunctional mucosal barrier of the small intestine in patients with chronic heart failure. Int J Cardiol. 2008;125(2):240-45. doi: 10.1016/j.ijcard.2007.11.103.
- Sandek A., Bauditz J., Swidsinski A., et al. et al. Altered intestinal function in patients with chronic heart failure. J Am Coll Cardiol. 2007;50(16):1561-69. doi: 10.1016/j.jacc.2007.07.016.
- Anker S.D., Egerer K.R., Volk H.D., et al. Elevated soluble CD14 receptors and altered cytokines in chronic heart failure. Am J Cardiol. 1997;79(10):1426-30. doi: 10.1016/s0002-9149(97)00159-8.
- Kumar A., Haery C., Parrillo J.E. Myocardial dysfunction in septic shock: Part I. Clinical manifestation of cardiovascular dysfunction. J Cardiothorac Vasc Anesth. 2001;15(3):364-76. doi: 10.1053/jcan.2001.22317.
- Gao C.Q., Sawicki G., Suarez-Pinzon W.L., et al. Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction. Cardiovasc Res. 2003;57(2):426-33. doi: 10.1016/s0008-6363(02)00719-8.
- Genth-Zotz S., von Haehling S., Bolger A.P, et al. Pathophysiologic quantities of endotoxin-induced tumor necrosis factor-alpha release in whole blood from patients with chronic heart failure. Am J Cardiol. 2002;90(11):1226-30. Doi: 10.1016/ s0002-9149(02)02839-4.
- Peschel T., Schönauer M., Thiele H., et al. Niebauer J. Invasive assessment of bacterial endotoxin and inflammatory cytokines in patients with acute heart failure. Eur J Heart Fail. 2003;5(5):609-14. doi: 10.1016/s1388-9842(03)00104-1. Erratum in: Eur J Heart Fail. 20041;6(2):245.
- Naito Y., Yoshikawa T. Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert. Rev. Gastroenterol. Hepatol. 2010;4(3):261-70. doi: 10.1586/egh.10.25.
- Lai Y., Zhong W., Yu T., et al. Rebamipide Promotes the Regeneration of Aspirin-Induced Small-Intestine Mucosal Injury through Accumulation of ß-Catenin. PLoS One. 2015;10(7):e0132031. doi: 10.1371/journal.pone.0132031.
- Watanabe T., Takeuchi T., Handa O., et al. A multicenter, randomized, double-blind, placebo-controlled trial of high-dose rebamipide treatment for low-dose aspirin-induced moderate-to-severe small intestinal damage. PLoS One. 2015;10(4):e0122330. doi: 10.1371/journal. pone.0122330.
- Yasuda-Onozawa Y., Handa O., Naito Y., et al. Rebamipide upregulates mucin secretion of intestinal goblet cells via Akt phosphorylation. Mol Med Rep. 2017;16(6):8216-22. Doi: 10.3892/ mmr. 2017.7647.
- Akagi S., Fujiwara T., Nishida M., et al. The effectiveness of rebamipide mouthwash therapy for radiotherapy and chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis. J Pharm Health Care Sci. 2019;5:16. Doi: 10.1186/ s40780-019-0146-2.
- Tarnawski A.S., Chai J., Pai R., Chiou S.K. Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action? Dig Dis Sei. 2004;49(2):202-9. doi: 10.1023/b:ddas.0000017439.60943.5c.
- Jhun J., Kwon J.E., Kim S.Y, et al. Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation. PLoS One. 2017;12(2):e0171674. doi: 10.1371/journal. pone.0171674.
- Choe J.Y., Park K.Y., Lee S.J., et al. Rebamipide inhibits tumor necrosis factor-a-induced interleukin-8 expression by suppressing the NF-kB signal pathway in human umbilical vein endothelial cells. Inflamm Res. 2010;59(12):1019-26. doi: 10.1007/s00011-010-0221-5.
- Tanigawa T., Watanabe T., Otani K., et al. Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of a-defensin 5. Eur J Pharmacol. 2013;704(1-3):64-9. doi: 10.1016/j.ejphar.2013.02.010