Urine levels of matrix metalloproteinases and their inhibitors as the marker of activity of chronic glomerulonephritis


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Abstract

MMP-2, MMP-9, TIMP-2, PAI-1, nephroscelrosis, chronic glomerulonephritis,
Urinary excretion matrix metalloproteinase (ММP-2 and ММP-9), tissue inhibitor MMP (ТIМP-2) and inhibitor of plasminogen type 1 activator (PAI-I) was investigated. Patients with chronic glomerulonephritis (CG) (I group (n=23) - CG with proteinuria of subnephrotic range (SNPU), II group (n=26) - CG with nephrotic syndrome (NS), III group (n=22) - CG with advanced proteinuria (PU) and transient renal failure (RF), IV group (n=15) - CG with high PU and permanent RF). With increasing of CG activity (advanced MS, NS appearance, acute nephritic syndrome development) we found relatively balanced increase of MMP, TIMP and PAI-I urine levels. In group of patients with permanent RF decrease of MMP urine excretion and acute increase of PAI-I concentration in the urine were found. The level of MMP and TIMP urine excretion at patients with progressive CG straightly correlated with 24-h PU level and inversely correlated with serum creatinine level. Conclusion: changes in MMP, TIMP and PAI-1 urinary excretion levels can be used as a marker of kidney disease activity and severity in chronic glomerulonephritis

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