OSOBENNOSTI REOLOGIChESKIKh SVOYSTV KROVI U BOL'NYKh VOLChANOChNYM NEFRITOM


Cite item

Full Text

Abstract

Purpose. Evaluation of rheological characteristics of blood in patients with lupus nephritis.
Materials and methods. The study enrolled 41 patients with systemic lupus erythematosis (SLE) (8 men aged 40 ± 14 years and 33 women aged 37 ± 12 years). Duration of a disease was 120 ± 108 months. Lupus nephritis (LN) was diagnosed in 30 patients. Patients were divided into three groups: those with inactive iLN (iLN), with active LN with urinary syndrome (aLN US) and with active LN with nephrotic syndrome (aLN NS). Patients with aLN have also been divided according to the level of hematuria (HU): the group with moderate HU (less than 10 thousand red blood cells/ml) and the group with severe HU (more than 10 thousand red blood cells/ml). The control group included 26 healthy individuals. Haemorheologial properties of blood - kinetics of spontaneous aggregation and disaggregation of erythrocytes in shear flow and deformation properties of red blood cells - were investigated by optical methods.
Results. Hemorheological changes were observed in all patients with SLE. In general, by comparison with control group, there was an increase in blood viscosity, reduction of deformability of red blood cells, acceleration of their aggregation, as well as increase the typical size of erythrocyte aggregates. Increase of aggregation of red blood cells was in parallel with the rise in blood viscosity. Patients with aLN have low time of red blood aggregation, the maximum size and strength of erythrocyte aggregates and the lowest deformability of red blood cells as compared with entire group of patients with SLE. The blood viscosity was growing in parallel with increase of LN activity. In the aLN group of patients with severe HU, typical size of erythrocyte aggregates was significantly higher than in moderate HU.
Conclusion. SLE patients demonstrated increased blood viscosity due to changes in aggregation and deformation properties of red blood cells, most pronounced in the presence of aLN.

References

  1. Гусева С.А., Вознюк В.П. Болезни системы крови. М., 2004. 488 с.
  2. Соколова И.А., Краснова Т.Н., Георгинова О.А. и др. Гемореологические особенности больных с разными клиническими проявлениями системной красной волчанки // Регионарное кровообращение и микроциркуляция. 2008. № 7(3). С. 45-53.
  3. Тареева И.Е. (ред.) Нефрология. Руководство для врачей. М., 2000. 295 c.
  4. Тареева И.Е., Краснова Т.Н. Поражение почек при системной красной волчанке. В кн.: Тареева И.Е. (ред.) Нефрология. Руководство для врачей. М., 2000. С. 280-291.
  5. Фирсов Н.Н., Приезжев А.В., Климова Н.В. и др. Основные закономерности деформационного поведения эритроцитов в сдвиговом потоке // Инженерно-физический журнал. 2006. № 79(1). С. 114-117.
  6. Booth S, Chohan S, Curran JC, et al. Whole blood viscosity and arterial thrombotic events in patients with systemic lupus erythematosus. Arthritis Rheum. 2007;57(5):845-50.
  7. Carvalho Lins CE, Pereira Crott LS, Barbosa JE. Reduced erythrocyte complement receptor type I in systemic lupus erythematosus is related to a disease activity index and not to the presence or severity of renal disease. Lupus 2004;13(7):517-21.
  8. Cameron JS. Lupus nephritis. J Am Soc Nephrol 1999;10:413-24.
  9. Ernst E, Hein A, Meurer M, et al. Blood rheology in lupus erythematosus. Ann Rheum Dis 1991;50(10):710-12.
  10. Fukasawa T, Arai T, Naruse T, et al. Hyperviscosity syndrome in a patient with systemic lupus erythematosus. Am J Med Sci 1977;273(3):329-34.
  11. Hazelton R, Lowe GD, Forbes CD, et al. Increased blood and plasma viscosity in systemic lupus erythematosus (SLE). J Rheumatol 1985;12(3):616-17.
  12. Hebert LA, Dillon JJ, Middendorf DF, et al. Relationship between appearance of urinary red blood cell/white blood cell casts and the onset of renal relapse in systemic lupus erythematosus. Am J Kidney Dis 1995;26(3):432-38.
  13. Klinger M, Kramarz S, Wendycz D, et al. Different erythrocyte and platelet surface electric charge in various types of glomerulonephritis. Nephrol Dial Transplant 1997;12(4):707-12.
  14. Korotaeva TV, Firsov NN, Bjelle A, et al. Erythrocytes aggregation in healthy donors at native and standard hematocrit: the influence of sex, age, immunoglobulins and fibrinogen concentrations. Standardization of parameters. Clin Hemorheol Microcirc 2007;36(4):335-43.
  15. Rahman P, Gladman DD, Ibanez D, et al Significance of isolated hematuria and isolated pyuria in systemic lupus erythematosus. Lupus 2001;10(6):418-23.
  16. Reid HL, de Ceulaer K. Abnormal plasma and serum viscosity in systemic lupus erythematosus (SLE): a Jamaican study. Clin Hemorheol Microcirc 1999;20(3):175-80.
  17. Rosenson RS, Shott S, Katz R. Elevated blood viscosity in systemic lupus erythematosus. Semin. Arthritis Rheum 2001;31(1):52-57.
  18. Schmid-Schonbein H, Rieger H, Gallasch G, et al. Pathological red cell aggregation (clump aggregation). Molecular and electrochemical factors. Bibl Anat 1977;16(Pt. 2):484-89.
  19. Vaya A, Murado J, Santaolaria M, et al. Haemorheological changes in patients with systemic lupus erythematosus do not seem to be related to thrombotic events. Clin Hemorheol Microcirc 2008;38(1):23-29.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies