PORAZhENIE POChEK I NARUShENIYa V SISTEME GEMOSTAZA PRI PODOSTROM INFEKTsIONNOM ENDOKARDITE


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Abstract

Aim of the study. Determination of kidney affection peculiarities and role of haemostasis disoders in it's development in infective endocarditis.
Material and methods. 120 patients with infective endocarditis were included into the study. In all of them routine blood and urine parameters, as well as bacteriological and haemostasis tests were performed. 2-dimension transthoracic and transesopahgeal echocardiography, ultrasound scanning of kidneys were also done.
Results. Sighs of kidney involvement were detected in 77% of patients. In 90,3% changes of the urinalysis were seen, in 87% - haematuria, in 50% - proteinuria, in 55% - leucocyturia. Chronic kidney failure developed in 33,3% patients. In 10% ultrasound sighs of renal infarction were detected. In 10 autopsies were shown, that all of this patients with infective endocarditis had glomerulophritis, most of them - membranoproliferative, 6 of them had kidney infarctions. In 43 (46,2%) of patients severe disorders of haemostasis system were detected. Changes of urinalysis correlated with severity of haemostasis system disorders.
Conclusion. Renal involvement in infective endocarditis is associated with various changes of the urine, renal failure and kidney infarctions are frequent. Membramoproliferative glomerulonephritis is the most frequent type of glomerulonephritis in infective endocarditis patients. Haemostasis disorders are often seen in infective endocarditis, associated with kidney involvement and determine the severity of the urine changes.

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