URINARY CONCENTRATION OF MATRIX METALLOPROTEINASES -2 AND -9 AND THEIR TISSUE INHIBITORS IN CHILDREN WITH PYELONEPHRITIS


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Abstract

Aim. Determination of role of matrix metalloproteinases (MMP) -2 and -9 and their tissue inhibitor (TIMP) in development and progression of pyelonephritis in children.
Methods. 80 children (mean age 8,79 ± 0,26 лет) with pyelonephritis were included into the study. Patients were divided into 4 groups: 1st (n=15) - patients with acute pyelonephritis, 2nd (n= 31) - patients with attack of chronic pyelonephritis, 3rd (n=26) - children with remission of chronic pyelonephritis without urodynamics disorders, 4th group (n=8) - children with chronic pyelonephritis, associated with urinary tract anomalies (vesico-uretral reflux, hydronephrosis, megaureter). 18 healthy children served as a contol group In all patients urinary activity of MMP-2, MMP-9 and TIMP were determined; in active pyelonephritis - at baseline and after 10 - 14 days of antibacterial therapy.
Results. All patients with pyelonephritis demonstrated elevation of excretion of MMP-2, MMP-9 and TIMP. Urinary excretion of MMP-9 was highest in patients with acute pyelonephritis in comparison with control group and patients with chronic pyelonephritis. Antibacterial therapy lead to decrease of urinary activity of MMP-2, MMP-9 and TIMP.
Conclusion. Urinary excretion of MMP and TIMP in pyelonephritis can detect activity of kidney damage and prognosis of renal disease.

References

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