Role of sulodexide in treatment of diabetic nephropathy in patients with type 1 diabetes mellitus
- Authors: Aleksandrovich GA1, Andreeva EI1, Markova AS1, Morozova NN1, Saneeva GA1, Unanova IA1, Alexandrovich GA1, Andreeva EI1, Markov AS1, Morozova NN1, Saneeva GA1, Unanova IA1
-
Affiliations:
- Issue: No 1 (2012)
- Pages: 34-35
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/261645
- ID: 261645
Cite item
Full Text
Abstract
Methods. 108 patients (19 male, 17 female, age 24-27 years, mean duration of DM 7 - 16 years) were included into the study. 62 patients at baseline had microalbuminuria, 46 - proteinuria. The duration of treatment course with sulodexide was 4 weeks.
Results. Patients with microalbuminuria demonstrated significant decrease of albuminuria, in 50% of them - to normalbuminruia. In patients with baseline proteinuria changes of albuminuria were not significant.
Results. Sulodexide demonstrates antiproteinuric effect in DM patients with DN
About the authors
G A Aleksandrovich
E I Andreeva
A S Markova
N N Morozova
G A Saneeva
I A Unanova
G A Alexandrovich
E I Andreeva
A S Markov
N N Morozova
G A Saneeva
I A Unanova
References
- Дедов И.И. Шестакова М.В. (ред.) Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 2-е изд., М., 2006.
- Бреговский В.Б. Матер. конф. "Роль гликозоаминогликанов (ГАГ) в лечении сосудистых осложнений сахарного диабета" Санкт-Петербург, 1996., 17.
- Балаболкин М.И. Клебанова Е.М. Креминская В.М. Дифференциальная диагностика и лечение эндокринных заболеваний. Руководство М., Медицина, 2002.
- Skrha J, Perusicova J, Pontuch P, Oksa A. Glycosaminoglycan sulodexide decreases albuminuria in diabetic patients. Diabetes Res Clin Pract 1997; 38(1): 25-31
- Шестакова М.В., Чугунова Л.А., Воронцов В.А. и др. Эффективность сулодексида - низкомолекулярного гепарина - в терапии диабетической нефропатии. Тер. арх. 1997; 6: 34-37
- Gambaro C., Kinalska I., Oksa A. et al. Oral sulodexide reduces albuminuria in microalbuminuria and macroalbuminuric type 1 and type 2 diabetic patients: the Di.N.A.S. randomized trial. J. Am. Soc. Nephrol. 2002; 13(6): 1615-1625.
- Heerspink HL, Greene T, Lewis JB et al. Effects of sulodexide in patients with type 2 diabetes and persistent albuminuria. Nephrol Dial Transplant 2008; 23(6): 1946-1954
Supplementary files
