Immunological matching in renal transplantation: clinical and prognostic significance


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Abstract

Aim. Estimation of influence of immunological selection of donor-recipient pair on renal allograft survival. Methods. Renal allograft survival was analyzed in 347 patients, undergone renal allotransplantation (mean age 36,98±0,60 years (12 - 58 years), 229 male, 118 female). HLA antigenes (a, b and DR-loci) were typed by serological method and genetic analysis. Results. Renal allograft survival improved in patients, in whom genetic analysis was used for selection of donor-recipient pair. Number of non-coincident antigen pairs influenced renal allograft survival, which was longest in patients with no dr loci non-coincidence. Conclusion. Immunological selection of donor-recipient pair is useful for prologation renal allograft survival.

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References

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