Impact of direct renin inhibitor on central hemodynamics parameters and thrombocytes structure and function in patients with chronic kidney disease and arterial hypertension

Aim. Assessment of influence of direct renin inhibitor on blood pressure (Bp), parameters of central hemodynamics and structure and functional status of thrombocytes in patients with arterial hypertension and chronic kidney disease (CKD). Methods. 50 patients (23 male and 27 female, mean age 43,5 + 3,2 years) with arterial hypertension and CKD were included into the study. Glomerular filtration rate was estimated according to MDRD formula. All patients recieved direct renin inhibitor aliskiren (Rasilez, Novartis AG). Office bp, echocardiography, thrombocyte aggregation and mebrane lipid phase determination were performed. Results. after 8 weeks of aliskiren therapy systolic and diastolic bp decreased significantly, target bp level reached 32 (64%) of patients. Left ventricular myocardial mass index decreased; degree and velocity of thrombocytes aggregation, lipid peroxidation diminished, alpha-tocopherol and phospholipid content in thombocyte membrane increased. Conclusion. Use of aliskiren in patients with chronic kidney disease and arterial hypertension in associated with achievement of target bp in the majority of patients, regression of left ventricular hypertrophy and normalisation of structure and functional status of thrombocytes.

chronic kidney disease, arterial hypertension, aliskiren, thrombocytes membrane