Estimation of influence of loop diuretics with different elimination period on sodium retention


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Abstract

Aim. Estimation of influence of peack natriuresis on sodium reabsorbtion enchancement and it's association with urinary excretion of Tamm-Horsfal protein (ТНР). Methods. 28 patients (mean age 47 ± 7,5 years) were included into the study. All patients were randomized to torasemide SR (n = і4) and torasemide IR (n = і4). Sodium excretion was determined in 8 urinary portions, collected every 3 hours during 24 hours; urinary excretion of THP was also analyzed. Questionnarie «Charlton: Salt Screener» was used for determination of salt intake. Results. Area under curve (AUC) of torasemide SR and torasemide IR did not differ significantly, but torasemide SR induced more prolonged diuresis. During 06.00-09.00 no differences in torasemide SR and torasemide IR-induced sodium reabsorbtion were observed, in 09.00—і2.00 interval sodium reabsorbtion demostrated peack of diuretic efficacy, in і2.00—і5.00 sodium reabsorbtion was enchanced in patients on torasemide IR. Sodium reabsorbtion restoration was seen in 24.00-03.00. Peack of urinary ТНР concentration was seen in period of maximum sodium retention. Conclusion. Torasemide SR is characterized by more prolonged elimination period, prolonged natriuresis and absence of sodium retenstion and elevation of Tamm-Horsfal protein.

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