Angiotensin converting enzyme gene polymorphism in children with reflux nephropathy


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Abstract

This study involving 94 children examines the association of angiotensin converting enzyme gene polymorphism with the formation and progression of reflux nephropathy and urinary levels of profibrogenic cytokines: angiotensin II and transforming growth factor ßl. The study aimed to support early treatment with angiotensinconverting enzyme. The authors found no differences in the distribution of ace genotypes between the group of patients with vesicoureteral reflux (VUR) and the control group. It is shown that the D/D-genotype of the ace gene is an independent risk factor for development and progression of renal scarring in children with vesicoureteral reflux. It is demonstrated by the association of the D/D-genotype with higher grade of VUR, more severe reflux nephropathy, more frequent impairment of renal filtration and concentrating function and greater increase in urinary levels of profibrogenic cytokines.

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