Predictors of chronic kidney disease in workers of locomotive crews


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Purpose. To establish a causal relationship between the development and progression of chronic kidney disease in workers of locomotive crews. Material and methods. In 2008-20і3 7959 workers of railway train crews of Trans-Baikal Railway, undergoing periodic health assessments were examined for the presence of cardiovascular disease risk factors and target organ damage. Results. Over the study period standard evaluation of subclinical manifestations of atherosclerosis in patients with kidney disease was carried out in 7959 subjects. Elevated creatinine levels was found in ii6 cases, proteinuria and reduced glomerular filtration rate were observed in 8-6 cases. Statistical analysis showed that excessive alcohol intake, dyslipidemia, retinopathy, and family history of early cardiovascular disease led the development of proteinuria. Reduced glomerular filtration rate, retinopathy, body mass index and BMI>25,0 were associated with the increase of serum creatinine level. Reduced glomerular filtration rate caused increase of serum creatinine level, hyperglycemia and atherosclerosis of the aorta. Conclusion. The findings necessitate inclusion of tests for proteinuria, serum creatinine and GFR calculation in of mandatory health assessment of workers of locomotive crews as preventive measures for CKD and CVD.

Full Text

Restricted Access

References

  1. Кардиоваскулярная профилактика. Рекомендации ВНОК. Кардиоваскулярная терапия и профилактика. 2011;10(6):7-63.
  2. Рекомендации по диагностике и лечению артериальной гипертонии Европейского общества по гипертонии (ESH) и Европейского общества кардиологов (ESC). 2013:26-7.
  3. Диагностика и лечение артериальной гипертензии. Рекомендации РМОАГ и ВНОК. Кардиоваскулярная терапия и профилактика. 2008;7(6):7-8.
  4. Henry R.M., Kostense P.J., Bos G., Dekker J.M., Nijpels G., Heine R.J., Bouter L.M., Stehouwer C.D. Mild renal insufficiency is associated with increased cardiovascular mortality: the Шот Study. Kidney Int. 2002;62:1402-7.
  5. Majunath G., Tighionart H., Ibrahim H., MacLeod B., Salem D.N., Griffith J.L., Coresh J., Levey A.S., Sarnak M.J. Level of kidney function as risk factors for atherosclerotic cardiovascular outcomes in the community. J. Am. Coll. Cardiol 2003;41:47-55.
  6. Mann J.F.E. Cardiovascular risk in patients with mild renal insufficiency: implication for the use of ACE inhibitors. La Presse Medicate. 2005;34(18):1303-8.
  7. Nitsch D., Dietrich D.F., von Eckardstein A. Gaspoz J.M., Downs S.H., Leuenberger P., Tschopp J.M., Brändli O., Keller R., Gerbase M.W., Probst-Hensch N.M., Stutz E.Z., Ackermann-Liebrich U.; SAPALDIA team. Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALD1A study. Nephrol. Dial. Transplant. 2006;21(4):935-44.
  8. Levey A.S., de Jong P.E., Coresh J., Nahas M., Astor B.C., Matsushita K., Gansevoort R.T., Kasiske B.L., Eckardt K.U. The definition, classification, and prognosis of chronic kidney disease - a KD1GO Controversies Conference report. Kidney Int. 2011;80(1):17-28.
  9. Forman J.P., Brenner B.M. «Hypertension» and «microalbuminuria». Kidney Int. 2006;69:22-8.
  10. Schmieder R.E., Schroder J., Zidek W. Tebbe U., Paar W.D., Bramlage P., клиническая нефрология №2-3 - 2015 Pittrow D., Böhm M. Low-grade albuminuria and cardiovascular risk: what is the evidence? Clin. Res. Cardiol. 2007;96(5):247-57.
  11. Klausen K.P., Scharting H., Jensen G., Jensen J.S. New definition of microalbuminuria in hypertensive subjects - association with incident coronary heart disease and death. Hypertension. 2005;46 (1):33-7.
  12. Смирнова А.В., Каюков И.Г., Добронравов В.А. Концепция факторов риска в нефрологии. Вопросы профилактики и лечения хронической болезни почек. Нефрология. 2008;12(1):7-13.
  13. Крупнова М.Ю., Бондаренко М.В., Марасаев В.В. Факторы риска развития и прогрессирования хронической болезни почек. Клиническая нефрология. 2013;5:53-9.
  14. Об утверждении перечня медицинских противопоказаний к работам, непосредственно связанным с движением поездов и маневровой работой. Приказ Минздравсоцразвития РФ №796 от 19.12.2005 г.
  15. Клочкова Е.А. Охрана труда на железнодорожном транспорте. Учебник для техникумов и колледжей железнодорожного транспорта. М.: Маршрут, 2004.
  16. Ультразвуковое исследование сердца и сосудов. Под ред. О.Ю. Атькова. М. : ЭКСМО, 2009.
  17. Amiko G.D. Tubulointerstitium as predictor of progression of glomerular diseases. Nefron. 1999;83(4):289-95.
  18. Hruby Z., Smolska D., Filipowski H., Rabczyński J., Cieślar E., Kopeć W., Dulawa J. The importance of tubulointerstitial injury in the early of primary glomerular disease. J. Intern. Med. 1998;243(3):215-22.
  19. Чеботарева H.B., Вобкова И.Н., Козловская Л.В. Молекулярные механизмы интерстициального фиброза при прогрессирующих заболеваниях почек. Нефрология и диализ. 2006;1:26-35.
  20. Risdon R.A., Sloper J.-С., Wardener Н.Е. Relationship between renal function and histologic changes in renal-biopsy specimens from patients with persistents glomerular nephritis. Lancet. 1968;2:363-70.
  21. Schainuk L., Striker G., Cutler R., Benditt E.P. Structural-functional correlations in renal disease. Hum. Pathol. 1970;1:631-41.
  22. Marcussen N. Atubular glomeruli in cisplatin-induced chronic interstitial nephropathy. APMIS. 1990;98:1087-97.
  23. Marcussen N. Tubulointerstitial damage leads to atubularglomeruli-significance and possible role in progression. Nephrol Dial Transplant. 2000;15(6):74-5.
  24. Becker G.J., Hewitson T.D. The role of tubulointerstitial injury in chronic renal failure. Curr. Opin. Nephrol. Hypertens. 2000;9:133-8.
  25. Арутюнов Г.П., Драгунов Д.О., Соколова А.В. Влияние петлевых диуретиков с различным периодом полувыведения на динамикун атрийуреза и показатели, характеризующие состояние тубулоинтерстициальной ткани почек. Терапевтический архив. 2014;86(6):38-44.
  26. Segerer S., Nelson P., Schlondorff D. Chemokines, Chemokine Receptors and renal disease - from basic science to pathophysiologic and therapeutic studies. J. Am. Soc. Nephrol. 2000;11:152-76.
  27. Burton C.Y., Walls Y. Interstitial inflammation and scarring-massages from the proximal tubular cell. Nefrol. Dial. Transplant. 1996;11:1505-8.
  28. Мухин Н.А., Козловская Л.В., Кутырина И.М. и др. Ишемическая болезнь почек. Терапевтический архив. 2003;6:5-11.
  29. Eddy А.А. Proteinuria and interstitial injury. Nephrol. Dial. Transplant. 2004;19:277-81.
  30. Burton C., Harris K.P.G. The role of proteinuria in the progression of chronic renal failure. Am. J. Kidney Dis. 1996;27:765-75.
  31. Meyer T.W. Tubular injury in glomerular disease. Kidney Int. 2003; 63:774-87.
  32. Benigni A. Tubulointerstitial disease mediators of injury - the role of endothelin. Nephrol. Dial. Transplant. 2000;15(6):50-2.
  33. Evan A.P., Tanner G.A. Proximal tubule morphology after single nephron obstruction in the rat kidney. Kidney Int. 1986;30:818-27.
  34. Bertani T., Cutillo F., Zoja C., Broggini M., Remuzzi G. Tubulointerstitial lesions mediate renal damage in adriamycin glomerulopathy. Kidney Int. 1986;30:488-96.
  35. Eddy A.A. Interstitial nephritis induced by protein-overload proteinuria. Am. J. Pathol. 1989;135:719-33.
  36. Schreiner G.F. Renal toxicity of albumin and other lipoproteins. Curr. Opin. Nephrol. Hypertens. 1995;151:369-73.
  37. Tang S., Lai K.N., Chan T.M., Lan H.Y., Ho S.K., Sacks S.H. Transferrin but not albumin mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells. Am. J. Kidney Dis. 2001;37:94-103.
  38. Riser D., Ritz E. Renal haemodynamics in the elderly. Nephrol. Dial. Transplant. 1996;11(9):2-8.
  39. Muntner P., Coresh J., Smith C., Eckfeldt J., Klag M.J. Plasma lipids and risk of developing renal dysfunction: The Atherosclerosis Risk in Communities Study. Kidney Int. 2000;58:293-301.
  40. Schaeffher E.S., Kurth Т., Curhan G.C., Glynn R.J., Rexrode K.M., Baigent C., Buring J.E., Gaziano J.M. Cholesterol and the risk of renal dysfunction in apparently healthy men. J. Am. Soc. Nephrol. 2003;14:2084-91.
  41. Samuelsson O., Mulec H., Knight-Gibson С., Attman P.O., Kron B., Larsson R., Weiss L., Wedel H., Alaupovic P. Lipoprotein abnormalities are associated with increased rate of progression of human chronic renal insufficiency. Nephrol. Dial. Transplant. 1997;12:1908-15.
  42. Manttary M., Tiula E., Alikoski T., et al. Effect of hypertension and dyslipidemia on the declaim in renal function. Hypertension. 1995;26:670-5.
  43. Hunsicker L.G., Adler S., Caggiula A., England B.K., Greene T., Kusek J.W., Rogers N.L., Teschan P.E. Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study. Kidney Int. 1997;51:1908-19.
  44. Trevisan R., Dodesini A.R., Lepore G. Lipids and renal disease. J. Am. Soc. Nephrol. 2006;17:S145-7.
  45. Keane W.F., Kasiske B.L., O’Donnel M.P. Lipids and progressive glomerulosclerosis. A model analogous to atherosclerosis. Am. J. Nephrol. 1988;8:261-71.
  46. Руденко Т.Е., Кутырина И.М., Швецов М.Ю. Состояние липидного обмена при хронической болезни почек. Клиническая нефрология. 2012;2:14-21.
  47. Болезни сердца и сосудов. Под ред. А.Д. Кэмма, Т.Ф. Люшера, П.В. Серруиса. М.: ГЭОТАР-Медиа, 2011.
  48. Арутюнов А.Т., Оганезова Л.Т. Тубулоинтерстициальный аппарат почки и его поражение при артериальной гипертензии. Клиническая нефрология. 2011;1:52-7.
  49. Jafar Т.Н., Stark P.C., Schmid C.H., Landa M., Maschio G., de Jong P.E., de Zeeuw D., Shahinfar S., Toto R., Levey A.S.; AIPRD Study Group. Progression of chronic kidney disease: the role of blood pressure control proteinuria and angiotensin-converting enzyme inhibition: a patient-level metaanalysis. Ann. Intern. Med. 2003;139:244-52.
  50. Мухин А.С. и др. Алкогольная болезнь почек (алкогольная нефропатия). Терапевтический архив. 1978;50(6):79.
  51. Руководство по постпрандиальной гипергликемии. International Diabetes Federation. 2007. P. 12.
  52. Othman M., Kawar B., Nahas A.M. Influence of obesity on progression of non-diabetic chronic kidney disease: a retrospective cohort study. Nephron. Clin. Pract. 2009;113(1):16-23.
  53. Goumenos D.S., Kawar B., El Nahas M., Conti S., Wagner B., Spyropoulos C., Vlachojannis J.G., Benigni A., Kalfarentzos F. Early histological changes in the kidney of people with morbid obesity. Neprol. Dial. Transplant. 2009;24(12):3732-8.
  54. Kriz W., Hartmann I., Hosser H., Hähnel B., Kränzlin B., Provoost A., Gretz N. Tracer studies in the rat demonstrate misdirected filtration and peritubular filtrate spreading in nephrons with segmental glomerulosclerosis. J. Am. Soc. Nephrol. 2001;12:496-506.
  55. Тареева И.Е., Бобкова И.Н., Козловская Л. В. и др. Механизмы прогрессирования гломерулонефрита. Под ред. И.Е. Тареевой. Нефрология. Руководство для врачей. М.: Медицина, 2000. 688 с.
  56. Abbate М., Zoja С., Corna D., Capitanio M., Bertani T., Remuzzi G. In progressive nephropathies overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation. J. Am. Soc. Nephrol. 1998;9:1213-24.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies