Relationship of hyperchemerinemia and parameters of nutritive status in patients with chronic renal insufficiency


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The aim of the study was to reveal the relationship between the serum chemerin levels and certain parameters that reflect the development of disorders of nutritional status. Patients and methods: The study included 83 patients from two ambulatory hemodialysis centers. All patients underwent anamnestic, anthropometric, and laboratory examination; the results of additional methods of diagnosis were analyzed, including carpal dynamometry and other physical examination data; also, serum chemerin levels were assessed. Results. As a result of the study, the following data were obtained: significantly elevated chemerin levels were detected in all subjects absolutely (its concentration was 450.і ng/ml), while the level of this indicator was on the average within 524.68±82.45 ng/ml in women, and 392.67±80.34 ng/ml in men, it was higher than the normal indices of healthy people. During the study, a positive correlation between the subcutaneous fat thickness over the abdomen and the serum chemerin level was found (r=0.49, p<0.012), and a relationship between the plasma chemerin level and the dry weight of the patient (r=-0.3; p<0.014) was established. Data have been obtained indicating a negative correlation of capral dynamometry (r=-0.44, p<0.001) with serum chemerin level and serum creatinine level (r=-0.473, p<0.005). As a result of the study, a positive correlation between the serum chemerin level and the duration of the disease was found (r=0.61, p<0.001). Conclusion. Thus, data on the role of chemerin in metabolic processes and nutritional status parameters in patients with ESRF receiving RRT by PHD were obtained.

Full Text

Restricted Access

References

  1. Шалягин Ю.Д., Швецов М.Ю., Шилов Е.М. Распространенность снижения скорости клубочковой фильтрации. Нефрология и диализ. 2009; 11(4): 336-337.
  2. Перлин Д.В., Кретов М.А., Лялюев А.М. Нарушение нутритивного статуса при хронической болезни почек. Уч. пособие. Волгоград: ВолГМУ. 2014; 4-5.
  3. Walser M. Dialysis and protein malnutrition. Kidney Int. 1999; 56(1): 353.
  4. Pedrini L.А., Cozzi G. Convective and mixed dialysis technique. G Ital Nefrol. 2007; 24(6): 498-509.
  5. Bozaoglu K., Bolton K., McMillan J. Chemerin is a novel adipokine associated with obesity and metabolic syndrome.Endocrinology. 2007; (148): 4687-4694.
  6. Goralski K.B., McCarthy T.C., Hanniman E.A. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism J. Biol. Chem. 2007; (282): 28175-28188.
  7. Roh S.G., Song S.H., Choi K.C. Chemerin - A new adipokine that modulates adipogenesis via its own receptor. Biochem. Biophys. Res. Commun. 2007; (362): 1013-1018.
  8. Sell H., Divoux A., Poitou C. Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J. Clin. Endocrinol. Metab.2010; (95): 2892-2896.
  9. Sell H., Divoux A., Poitou C. Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J. Clin. Endocrinol. Metab. 2010; (95): 2892-2896.
  10. Du X.-Y., Leung L.L.K. Proteolytic regulatory mechanism of chemerin bioactivity. Acta Biochim. Biophys. Sin. 2009; (4): 973-979.
  11. Wittamer V., Bondue B., Guillabert A. Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity. J. Immunol. 2005; 175: 487-493.
  12. Cash J.L., Hart R., Russ A. Synthetic chemerin-derived peptides suppress inflammation through ChemR23. J. Exp. Med. 2008; (205): 767-775.
  13. Wittamer V., Franssen J.D., Vulcano M. Specific recruitment of antigenpresenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J. Exp. Med. 2003; (198): 977-985.
  14. Albanesi C., Scarponi C., Pallotta S. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J. Exp. Med.2009; (206): 249-258.
  15. Cash J.L., Hart R., Russ A. Synthetic chemerin-derived peptides suppress inflammation through ChemR23. J. Exp. Med. 2008; (205): 767-775.
  16. Pfau D., Bachmann A., L"Ossner U. Serum Levels of the Adipokine Chemerin in Relation to Renal Function. Diabetes Care. 2010; 33(1): 171-173.
  17. Hu W., Feng P. Elevated serum chemerin concentrations are associated with renal dysfunction in type 2 diabetic patients. Diabetes Research and Clinical Practice 2011; (91): 159-163.
  18. Rutkowski P., Sledzinski T., Zielinska H. Decrease of serum chemerin concentration in patients with end stage renal disease after successful kidney transplantation. Requl Pept. 2012; 173(1-3): 55-59.
  19. Yamamoto T., Qureshi A.R., Anderstam B. Clinical importance of an elevated circulating chemerin level in incident dialysis patients.Nephrol. Dial. Transplant. 2010; (25): 4017-4023.
  20. Xie Q., Deng Y., Huang C. Chemerin-induced mitochondrial dysfunction in skeletal muscle. J Cell Mol Med. 2015; 19(5): 986-995.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies