Qinical and pathological correlation of glomerulopathy in patients living in the Kyrgyz Republic


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. Creation of a unified register of renal biopsies of the Kyrgyz Republic (RBKR). Establishment of relationship between morphological and clinical manifestations of glomerulopathy. Material and methods. The study included 245 patients who underwent a study of renal tissue samples obtained in vivo by percutaneous biopsy from 2015 to 2019. All patients underwent a complex of general clinical, biochemical, immunological, instrumental and morphological studies. Results. In the pediatric cohort, 41 (4і.8%) patients with hematuria combined with nephrotic proteinuria were followed-up, and it was the maximum number of all examined children. Patients with nephritic and nephrotic syndromes were detected with the same frequency in 27 (27.5%) and 22 (22.4%) patients, respectively. Isolated urinary syndrome was detected only in 8 (8.і6%) patients. In the adult cohort, nephritic-range proteinuria was more often recorded - in 96 (65.3%) patients. Isolated urinary syndrome was observed in 30 (20.4%) patients. It should be emphasized that the incidence of all clinical manifestations (proteinuria with and without hematuria) compared with children differed. Conclusion. The most common variants of glomerular lesion in adults includrd membranous glomerulonephritis (MN [38%]) and immunoglobulin A nephropathy (IgAN; 29.2%), whereas in children IgAN and the minimal change glomerulonephritis dominated, in 20.4 and і9.3%, respectively.

Full Text

Restricted Access

About the authors

D. A Ayipova

National Center for Cardiology and Therapy n.a. Acad. Mirsaid Mirrakhimov of the Ministry of Health of the Kyrgyz Republic

Email: dinaralievna@gmail.com
Researcher at the Department of Nephrology Bishkek, Kyrgyz Republic

N. A Beishebaeva

National Center for Maternal and Child Health

Email: beishebaevanasira@gmail.com
PhD in Medical Sciences, Head of the Department of Nephrology Bishkek, Kyrgyz Republic

K. A Uzakbaev

National Center for Maternal and Child Health

PhD in Medical Sciences, Professor, Director Bishkek, Kyrgyz Republic

R. R Kaliev

I.K. Akhunbaev Kyrgyz State Medical Academy

Email: karys2002@mail.ru
PhD in Medical Sciences, Professor at the Department of Faculty Therapy Bishkek, Kyrgyz Republic

References

  1. Калиев Р.Р., Миррахимов М.М. Проблемы нефрологической службы в Кыргызской Республике в начале XXI века. ЦАМЖ. 2008;14(6):458-464.
  2. Калиев Р.Р., Миррахимов М.М. и др. Развитие нефрологии в Кыргызстане. ЦАМЖ. 2007;13(1):25-8.
  3. Eckardt K.U., Berns J.S., Rocco M.V., et al. Definition and classification of CKD: the debate should be about patient prognosis-a position statement from KDOQIand KDIGO. Am. J. Kidney Dis. 2009;53:915-920.
  4. Levey A.S., de Jong P.E., Coresh J., et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int. 2011;80:17-28. Doi: https://doi.org/10.1038/ki.2010.483
  5. Швецов М. Значение пункционной биопсии почки в нефрологии. Врач. 2002;6:29-31.
  6. Тареев Е.М., Серов В.В. Современная нозология и патоморфология заболевания почек. Арх. патол. 1975;7:3-11.
  7. Варшавский В.А., Сорокина М.Н., Томилина Н.А., Куприянова Л.А. Клинико-функционально-морфологическое изучение почек при гломерулонефрите. Арх. патол. 1975;1:73-80.
  8. Варшавский В.А., Голицына Е.П., Столяревич Е.С., Пальцева Е.М. Морфологические критерии прогрессирования хронических болезней почек. Нефрология. Национальное руководство. 2014.
  9. Rane S., Mutyal P., Dcunha N., et al. Clin. Diagn. Res. Role of Immunofluorescence in Adult Onset Nephrotic Syndrome-A Study in a Tertiary Care Centre of Western India. 2017;11(5).
  10. Нефрология. Руководство для врачей. Под ред. И.Е. Тареевой. 2000;2:688 с. [Nephrology. A Guide for Doctors. Ed. by I. Ye. Tareyevoy. 2000;2:688 s. (In Russ.)].
  11. Stevens L.A., Viswanathan G., Weiner D.E. Chronic kidney disease and end-stage renal disease in the elderly population: current prevalence, future projections, and clinical significance. Adv. Chronic. Kidney Dis. 2010;17:293- 301. doi: 10.1053/j.ackd.2010.03.010.
  12. Moutzouris D.A., Herlitz L., Appel G.B., Markowitz G.S., Freudenthal B., Radhakrishnan J., et al. Renal biopsy in the very elderly. Clin. J. Am. Soc. Nephrol. 2009;4:1073-1082. doi: 10.2215/CJN.00990209
  13. Nair R., Bell J.M., Walker P.D. Renal biopsy in patients aged 80 years and older. Am. J. Kidney Dis. 2004;44:618-626.
  14. Haas M., Spargo B.H., Wit E.J., Meehan S.M. Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases. Am. J. Kidney. 2000;35:433-447.
  15. Bomback A.S., Herlitz L.C., Markowitz G.S. Renal biopsy in the elderly and very elderly: useful or not? Adv. Chronic Kidney Dis. 2012; 19:61-7. doi: 10.1053/j.ackd.2011.09.003.
  16. Simon P., Rame'e M.P., Autuly V., et al. Epidemiology of primary glomerular disease in a French region. Variations according to period and age. Kidney Int. 1994;46:1192-1198.
  17. Uezono S., Hara S., Sato Y., Komatsu H., Ike da N., Shimao Y., et al. Renal biopsy in elderly patients: a clinicopathological analysis. Ren. Fail. 2006;8:549-555. doi: 10.1080/08860220600840165
  18. Levison S.P Renal disease in the elderly: the role of the renal biopsy. Am. J. Kidney Dis. 1990;16:300-306.
  19. Prakash J., Singh A.K., Saxena R.K. Usha. Glomerular diseases in the elderly in India. Int. Urol. Nephrol. 2003;35:283-288.
  20. Brown C.M., Scheven L., O’ Kelly P., Dorman A.M., Walshe J.J. Renal histology in the elderly: indications and outcomes. J. Nephrol. 2012;25:240- 244. doi: 10.5301/JN.2011.8447.
  21. Rychlik I., Jancova E., Tesar V., et al. The Czech registry of renal biopsies. Occurrence of renal diseases in the years 1994-2000. Nephrol. Dial. Transplant. 2004;19:3040-3049. doi: 10.1093/ndt/gfh521
  22. World Health Organization. Health statistics and information systems. WHO, 2016. http://www.who.int/healthinfo/survey/ageingdefnolder/en/.
  23. Registro Espanol de Glomerulonefritis. Epidemiologia de las glomerulonefritis en Espana. Resultadas de 1993. Nefrologia. 1995;15:435-444.
  24. Fiorentino et al. Renal Biopsy in 2015 - From Epidemiology to Evidence-Based Indications Am. J. Nephrol. 2016;43:1-19. doi: 10.1159/000444026.
  25. Mubarak M. IgA nephropathy: an update on pathogenesis and classification. Journal of the College of Physicians and Surgeons-Pakistan: JCPSP. 2011;21(4):230.
  26. Bartosik L.P., Lajoie G., Sugar L., Cattran D.C. Predicting progression in IgA nephropathy. American journal of kidney diseases. 2001;38(4):728-735.
  27. Woo K., Edmondson R., Wu A., Chiang G., Pwee H., Lim C. The natural history of IgA nephritis in Singapore. Clinical nephrology. 1986;25(1):15.
  28. Schena F.P Survey of the Italian registry of renal biopsies. Frequency of the renal diseases for 7 consecutive years. The Italian Group of Renal Immunopathology. Nephrol. Dial. Transplant. 1997;12:418-426.
  29. Eddy A.A., Symons J.M. Nephrotic syndrome in childhood. Lancet. 2003;362:629-639.
  30. Elie V., Fakhoury M., Deschenes G, Jacqz-Aigrain E. Physiopathology of idiopathic nephrotic syndrome: lessons from glucocorticoids and epigenetic perspectives. Pediatr. Nephrol. 2012;27(8):1249-1256. doi: 10.1007/s00467-011-1947-1.
  31. Rivera F., Lopez-Gomez J.M., Perez-Garcia R. Spanish Registry of Glomerulonephritis: clinicopathologic correlations of renal pathology in Spain. Kidney Int. 2004;66:898-904. doi: 10.1111/j.1523-1755.2004.00833.x.
  32. Braun N., Schweisfurth A., Lohofener C., Lange C., Grundemann C., Kundt G., Grone H.J. Epidemiology of glomerulonephritis in Northern Germany. Int Urol. Nephrol. 2011;43(4):1117-1126. doi: 10.1007/s11255-011-9955-4.
  33. Hanly J.G., O’Keeffe A.G., Su L., et al. The frequency and outcome of lupus nephritis: results from an international inception cohort study. Rheumatology (Oxford). 2016;55(2):252-262. doi: 10.1093/rheumatology/kev311.
  34. Glassock R.J., Fervenza F.C., Hebert L., et al. Nephrotic syndrome redux. Nephrol. Dial. Transplant. 2014. doi: 10.1093/ndt/gfu077.
  35. Orth S.R., Ritz E. The nephrotic syndrome. N. Engl. J. Med. 1998;338:1202- 1211. doi: 10.1056/NEJM199804233381707.
  36. Jalalah S.M., Jamal A.A. Childhood primary glomerular disease in the western region of Saudi Arabia, Saudi J. Kidney Dis. Transpl. 2009;20:608-612.
  37. Balakrishnan N., John G.T., Korula A., et al. Spectrum of biopsy proven renal disease and changing trends at a tropical tertiary care centre 1990-2001. Ind. J. Nephrol. 2003;13:29-35.
  38. Abdelraheem M.B., Ali E.M., Mohammad R.M., et al. Pattern of glomerular disease in Sudanese children: a clinico pathological study, Saudi J. Kidney Dis. Transpl. 2010;21:778-783.
  39. Perkowska-Ptasinska A., Bartczak A., Wagrowska-Danilewicz M., et al. Clinicopathologic correlations of renal pathology in adult population of Poland. Nephrol. Dial. Transplant. 2017;32:209-218. Doi: 10.1093/ ndt/gfw365.
  40. Komatsuda A., Nakamoto Y., Imai H., et al. Kidney diseases among the elderly - a clinicopathological analysis of 247 elderly patients. Intern. Med. 1993;32:377-381.
  41. Nair R., Bell J.M., Walker P.D. Renal biopsy in patients aged 80 years and older. Am. J. Kidney Dis. 2004;44:618-626.
  42. Gagnum V., Saeed M., Stene L.C., et al. Low Incidence of End-Stage Renal Disease in Childhood-Onset Type 1 Diabetes Followed for Up to 42 Years. Diabetes Care. 2018;41(3):420-425. Doi: 10.2337/ dc17-0906.
  43. Shree G.S., Andrew S., Bomback et al. The Modern Spectrum of Renal Biopsy Findings in Patients with Diabetes Clin. J. Am Soc. Nephrol. 2013;8:1718- 1724. doi: 10.2215/CJN.02510213.
  44. Gonzalez Suarez M.L., Thomas D.B., Barisoni L., Fornoni A. Diabetic nephropathy: is it time yet for routine kidney biopsy? World J. Diabetes. 2013;4:245-255. doi: 10.4239/wjd.v4.i6.245.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies