Renal dysfunction in patients with spondyloarthritis against the background of various long-term anti-inflammatory therapy
- Authors: Rebrov A.P1, Khondkaryan E.V.2, Aparkina A.V2, Gaydukova I.Z3,4
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Affiliations:
- Saratov State Medical University n.a. V.l. Razumovsky
- Saratov State Medical University n.a. V.I. Razumovsky
- North-Western State Medical University n.a. I.I. Mechnikov
- S
- Issue: No 2 (2019)
- Pages: 39-43
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/273226
- DOI: https://doi.org/10.18565/nephrology.2019.2.39-43
- ID: 273226
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Abstract
Objective. Assessment of renal dysfunction in patients with spondyloarthritis (SpA) who receive various longterm anti-inflammatory therapy during follow-up. Material and methods. The glomerular filtration rate (GFR), α1-microglobulin and urine albumin levels in patients with SpA who received various long-term anti-inflammatory therapy were evaluated initially and after 12 months of follow-up. Results. A decrease in GFR less than 90 ml/min/1.73 m2 was detected in 64 (49.2%) patients with SpA who took non-steroidal anti-inflammatory drugs (NSAIDs) with glucocorticosteroids (GCS), in 37 (52.8%) patients who took only NSAIDs (χ2=0.01, p=0.44). Tubular dysfunction and increased urinary albumin excretion were detected in 86.9% of patients taking NSAIDs alone and in 36.2% of patients taking NSAIDs and GCS (β1 2=4.93; p=0.01). After 12 months of follow-up, in patients with SpA who took NSAIDs and GCS, GFR was higher compared to baseline value: 96 (89-109) and 88 (80-104) ml/min, respectively (p=0.04). In patients who took only NSAIDs, GFR after 12 months of follow-up was 85.5 (77-104) ml/min, with initial GFR 87.5 (75.5-98) ml/min (p>0.05). A decrease in GFR after 12 months of follow-up was more frequently detected in patients who took only NSAIDs than in patients who took NSAIDs and GCS (61.7% and 47.3%, respectively, χ2 with Yates correction=3.4, p=0.03). Conclusion. SpA patients suffered from renal dysfunction of varying severity. At the same time, in patients who received a combination therapy including NSAIDs and GCS, renal dysfunction was less pronounced.
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About the authors
A. P Rebrov
Saratov State Medical University n.a. V.l. Razumovsky
Email: andreyrebrov@yandex.ru
Professor, Head of the Department of Hospital Therapy, Faculty of Medicine
E. V. Khondkaryan
Saratov State Medical University n.a. V.I. Razumovsky
Email: ersilasolnce@mail.ru
PhD in Medical Sciences, Teaching Assistant at the Department of Hospital Therapy, Faculty of Medicine
A. V Aparkina
Saratov State Medical University n.a. V.I. Razumovsky
Email: alena437539@yandex.ru
PhD in Medical Sciences, Teaching Assistant at the Department of Hospital Therapy, Faculty of Medicine
I. Z Gaydukova
North-Western State Medical University n.a. I.I. Mechnikov; S
Email: ubp1976@list.ru
PhD in Medical Sciences, Professor at the Department of Therapy, Rheumatology, Examination of Temporary Disability and the Quality of Medical Care n.a. E.E. Eichwald
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