Assessment of the risk of developing complications of type 2 diabetes mellitus in the Azerbaijani population using various formulas to calculate the glomerular filtration rate


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Abstract

Objective. Evaluation of alternative methods for calculating GFR in patients with type 2 diabetes mellitus (DM2) in the Azerbaijani population and identification the most informative ones. Material and methods. The study involved 186 ethnic Azerbaijanis with DM2 (age 55.8±7.7 years, DM2 duration - 5.6±3.2 years). A biochemical analyzer was used for clinical and laboratory examination. Microalbuminuria was determined by the immunochemical method. Statistical analysis was performed using Statistica 6.0 software. Results. The CKD-EPI formula was characterized by the smallest range and variability in GFR. When using the Cockroft-Gault formula, a significant overestimation of the calculated GFR values was noted. Clinical parallels between GFR parameters according to alternative calculation formulas and the clinical manifestations of diabetic nephropathy (DN) confirmed a progressive decrease in GFR in albuminuria. Clinical parallels between GFR and lipid spectrum, and highly sensitive C-reactive protein level were demonstrated. Conclusions. It is preferable to calculate GFR in an on-line calculator to identify DN in DM2. The greatest "consistency" of the CKD-EPI and MDRD formulas was revealed, especially at GFR <60 ml/min/1.78 m2. A correlation between the calculation of GFR using alternative formulas and the increase in clinical manifestations of DN, as well as the values of GFR with indicators of lipotoxicity and inflammation were established.

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About the authors

Ziba G. Akhmedova

Azerbaijan State Advanced Training Institute for Doctors named after A. Aliev

Email: еndo.ziba@qmail.com
Dr. Sci. (Med.), endocrinologist, Associate Professor at the Department of Therapy with the course of Endocrinolog Baku, Azerbaijan

Tofik V. Mekhtiev

Shaki Central District Hospital

Dr. Sci. (Med.), Head of the Endocrinology Department Azerbaijan

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