Vol 11, No 4 (2019)

Aim. To study the prevalence and clinical and functional characteristics of chronic kidney disease (CKD) among residents of urban and rural areas in the Kyrgyz republic. material and methods. the work examined the data of 1403 patients with ckd. depending on the living conditions, all participants were divided into residents of urban (n=1082) and rural (n=321) areas. all participants underwent general clinical and laboratory studies. glomerular reaction rate (GFR) was calculated using the formula using serum creatinine ckd-epi (chronic kidney disease, epidemiology), mdrd (diet modification for kidney disease), and creatinine clearance according to the Cockcroft-gault method. steps (C) are established in accordance with the recommendations of the nkf/kdoqi (National kidney organization/kidney disease outcomes initiative) proposed in 2009. risk factors for the development and progression of ckd were analyzed. overweight (BMI) was determined with a body mass index (BMI) of 25-29,9 kg/m2; obesity - with a bmi of >зо kg/m2. persons with an increase in heart rate (hr) >80 beats/min at rest were distinguished. for arterial hypertension, a level of systolic and/or diastolic blood pressure greater than or equal to 140/90 mm hg was taken. in each group, anemia was detected in the study participants (hemoglobin <120 g/l in women, <130 g/l in men), hyperuricemia (uric acid concentration in the blood >о,35 mmol /l in women, >о,42 mmol /l in men), hypercholesterolemia - ghs (total cholesterol >5.01 mmol/l) and proteinuria (pathological protein excretion in daily urine and/or single morning urine). results. in urban and rural residents, the estimated gfr values according to the formulas ckd-epi and mdrd did not significantly differ. Cockcroft-gault creatinine clearance showed higher gfr values especially in the early stages of ckd in both populations. the median of serum creatinine was significantly higher in urban residents at stage s of ckd (p<0,05). the prevalence of bmi at stage 1 among urban residents was significantly higher (27,5 versus 14,7%), and among rural residents at stage 4 ckd (40,o% versus 28,2%; p 80 beats/min (1 st) and proteinuria (3b st).

Objective: to establish the features of calcium and phosphorus metabolism and vitamin D levels in children with neurogenic bladder dysfunctions. material and methods. the study included 25 children suffering from neurogenic urination disorders, mean age was 10.4±з.6 years. the blood vitamin d, calcium, phosphorus, osteocalcin and parathyroid hormone levels and urine deoxypyridinoline level were evaluated. results. vitamin d deficiency was detected in 40% of children with neurogenic bladder dysfunctions, a reduced vitamin d level was additionally determined in another 32% of patients, and it was accompanied by secondary hyperparathyroidism in 12% of cases. identified violations of calcium and phosphorus metabolism included a decrease in blood calcium levels in 15% of the patients examined. Conclusion. the presence of correlations between the blood parathyroid hormone level and urine deoxypyridinoline level with the severity of symptoms and some parameters of the quality of life in children with neurogenic urination disorders may indicate the role of the revealed changes in the development of neurogenic urination disorders.