Clinical and morphological charasteristics of focal-segmental glomerulosclerosis in Kazakh children


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Aim. Characteristics of clinical and morphological signs of focal segmental glomerulosclerosis in Kazakh children. Methods. Focal segmental glomerulosclerosis (FSGS) was diagnosed in renal biopsy in 19 children with steroid-resistant nephrotic syndrome. Clinical, laboratory signs and renal prognosis were analyzed. Results. In 47,4% of children tip-lesion or typical variants of FSGS were found. Cellular and perihilar variants of FSGS were not found. There were significant correlations between glomerular and tubular damage. Arterial hypertension and hematuria, but not proteinuria, determinate poor prognosis in FSGS. Conclusion. One of the main causes of steroid-resistant nephrotic syndrome in Kazakh children is typical or tiplesion variants of focal segmental glomerulosclerosis.

Full Text

Restricted Access

References

  1. Reusz G., Szabo A., Fekete A. Nephrotic syndrome in childhood. Orv Hetil. 2006; 47:2251-2260.
  2. Ehrich J.H.H., Geerlings C., Zivicnjak M. et al. Steroid-resistant idiopathic childhood nephrosis: overdiagnosed and undertreated. Nephrol Dial Transplant. 2007; 228:2183-2193.
  3. Meyrier A. Mechanisms of disease: focal segmental glomerulosclerosis. Nat Clin Pract Nephrol 2005; 1: 44-45.
  4. D’Agati V., Fogo A., Jennette J. et al. Pathologic classification of focal segmental glomerulosclerosis: a working proposal. Am J of Kidney Dis. 2004; 43:368-382.
  5. Guttierez-Millet V., Nieto J., Praga M. et al. Focal glomerulosclerosis and proteinuria in patients with solitary kidneys. Arch Intern Med. 1986; 146: 705- 709.
  6. Praga M., Morales E., Herrero J.C. et al. Absence of hypoalbuminemia despite massive proteinuria in focal segmental glomerulosclerosis secondary to hyperfiltration. Am J Kidney Dis. 1999; 33:52-58.
  7. Pavenstadt H., Kriz W., Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev. 2003; 83: 253-307.
  8. Boerkel C.F., Hiroshi T., Joy J. et al. Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia. Nat Genet. 2002; 30: 215-220.
  9. Hall A.M., Unwin R.J. The not so ‘mighty chondrion’: emergence of renal diseases due to mitochtondrial dysfunction. Nephron Physio. 2007; 1: 1-10.
  10. Campbell H., Duke T., Weber M. et al. Global initiatives for improving hospital care for children:.State of art and future prospects. Pediatrics. 2008; 121:984-992.
  11. Ehrich J.H.H., Geerlings C., Zivicnjak M. et al.Steroid-resistant idiopathic childhood nephrosis: overdiagnosed and undertreated. Nephrol Dial Transplant. 2007; №8:2183-2193.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies