Local recurrence of prostate cancer in patients after radical prostatectomy. Modern methods of diagnosis and treatment (contrast-enhanced endorectal magnetic resonance imaging, hystoscanning, hifu)


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Abstract

Purpose. Improvement of the diagnosis and treatment in patients with prostate cancer. Materials and methods. The study included 54 patients with newly diagnosed BR after radical prostatectomy who underwent contrast-enhanced magnetic resonance imaging (endorectal coil 1.5 T) and hystoscanning. Local recurrence in 34 patients was morphologically confirmed by transrectal biopsy of VUA area. Results. 54 patients underwent HIFU treatment of local recurrence after radical prostatectomy in the Clinic of Urology of the First MSMU n.a. I.M. Sechenov for the period from October 2004 to February 2014. Prostate volume before RPE ranged from 21 to 102 cm 3. The median age was 62 years old, the minimum age of the patient was 46 years old, maximum age - 68 years. PSA levels before a HIFU sessions ranged from 0.4 to 18 ng/ml. Nadir PSA was 0.1 ng/ml and less after a 3-month follow-up. 5-year disease-free survival in patients with locally recurrent prostate cancer after HIFU (n = 54): in the group of low-risk prostate cancer, n = 14 (9і%), moderate-risk, n = 20 (84%), and high-risk, n = 20 (7і%). Conclusions. Contrast-enhanced magnetic resonance imaging (endorecal coil) is a highly informative method of diagnosis of local recurrence after radical prostatectomy, with specificity 64%, and sensitivity 96%; in the treatment process, HIFU is categorized as highly effective method of treatment.

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  1. Безруков Е.А. Динамическая магнитно-резонансная простатовезикулография при раке предстательной железы. - Клиника урологии ПМГМУ им. И.М. Сеченова. - 2002.
  2. Крупинов Г.Е. Лечение больных раком предстательной железы высокоинтенсивным фокусированным ультразвуком. - М.: Клиника урологии ПМГМУ им. И.М. Сеченова. - 2010.
  3. Братчиков О.И., Ильченко В.А., Шумакова Е.А. и др. Некоторые аспекты диагностики и лечения рака предстательной железы // Материалы I конгресса РООУ. - Москва. - 2006.
  4. Лопаткин Н.А., Сивков А.В., Аполихин О.И. и др. Рак предстательной железы (компакт-диск). - НИИ Урологии Минздрава РФ. - 2002.
  5. Azzouz Н. HIFU: Local Treatment of Prostate Cancer // EAU-EBU Update Series 4. - 2006. - P. 62-70.
  6. Blana A., Walter B., Rogenhofer S., et al. High-intensity focused ultrasound for the treatment of localized prostate cancer: 5-year experience // Urology. - 2004. - Vol. 63(2). - P. 297-300.
  7. Урология: учебник / Под ред. П.В. Глыбочко, Ю.Г. Аляева. - М.: Первый МГМУ им. И.М. Сеченова. - 2013.
  8. Сивков А.В., Кудрявцев Ю.В., Кешишев Н.Г. и др. HIFU-терапия местного рецидива рака предстательной железы после простатэктомии. -М.: ФГУ«НИИ урологии Росмедтехнологий». - 2010.
  9. Chaussy C., Thuroff S., Rebillard X. et al. High-intensity focused ultrasound: the insight on the technology // Nat. Clin. Pract. Urol. - 2005. - Vol. 2(4). -P. 191-198.
  10. Kremkau F.W. Cancer therapy with ultrasound: a historical review // J. Clin. Ultrasound. - 1979. - Vol. 7. - P. 287-300.
  11. Oosterhof G.O.N., Cornel E.B., Smits G.A.H.J. et al. Influence of high-intensity focused ultrasound on the development of metastases // Eur. Urol. -1997. - Vol. 32. - P. 91-95.
  12. Poissonnier L., Gelet A., Chapelon J.Y. et al. Results of transrectal focused ultrasound for the treatment of localized prostate cancer (120 patients with PSA < or + 10 ng/ml) // Prog. Urol. - 2003. - Vol. 13(1). - P. 60-72.
  13. Rebillard X., Gelet A., Davin J.L. et al. Transrectal high-intensity focused ultrasound in the treatment oflocalizedprostate cancer // J. Endourol. - 2005. -Vol. 19(6). - P. 693-701.
  14. Rewcastle J.C. High Intensity Focused Ultrasound for Prostate Cancer: 2006 Technology and Outcome Update. - http://www.hifu.ca/pdf/Rewcastle%202006%20HIFU%20Update.pdf
  15. Vallancien G., Prapotnich D., Cathelineau X. et al. Transrectal focused ultrasound combined with transurethral resection of the prostate for the treatment of localized prostate cancer; feasibility study // J. Urol. - 2004. -Vol. 171. - P. 2265-2267.

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