steroid resistant nephrotic syndrome in childhood: Single-centre experience


Дәйексөз келтіру

Толық мәтін

Аннотация

Aim. Assessment of survival of children with steroid-resistant nephrotic syndrome in Ukraine, determination of risk factors for chronic renal failure development.
Methods. Clinical evolution of 646 children with steroid-resistant nephrotic syndrome was performed according to the hospitalization periods (1980 - 2000 and 2001 - 2006).
Results Clinical and morphological dynamics of steroid-resistant nephrotic syndrome in children was detected. In 1980 - 2000 the main risk factors for chronic renal failure development were renal function deterioration in the debut of the diasease and arterial hypertension. In 2001-2006 cumulative risk of chronic renal failure decreased (27,7% vs 39,7% in 1980-2000, p=0,008). In 2001-2006 risk of chronic heart failure became higher in boys aged 3 - 6 years.
Conclusion. Dynamics of clinical and moprphological characteristics and chronic renal failure risk in children with chronic renal failure call for immunosuppressive therapy protocols optimization

Авторлар туралы

S Fomina

I Bagdasarova

T Pavlenko

Әдебиет тізімі

  1. Wong W. Idiopathic nephrotic syndrome in New Zealand children, demographic, clinical features, initial management and outcome after twelve-month follow-up: results of a three-year national surveillance study. J. Paediatr. Child Health. 2007; 4: 337-341.
  2. Kim J.S., Bellew C.A., Silverstein D.M. et al. High incidence of initial and late steroid resistance in childhood nephrotic syndrome. Kidney Int. 2005; 68: 1275-1281.
  3. Mekahli D. A. Liutkus, B. Ranchin et al. Long-term outcome of idiopathic steroid-resistant nephrotic syndrome: a multicenter study. Pediatr. Nephrol. 2009. Режим доступа: doi: 10.1007/s00467-009-1138-5.
  4. Avner E.D., Harmon W.E., Niaudet P. Pediatric nephrology. Philadelphia: Lippincott Williams & Wilkins. 2004. 543-573.
  5. Eddy A.A., Symons J.M. Nephrotic syndrome in childhood. Lancet. 2003; 362: 629-639.
  6. Tarshish P., Tobin J.N., Bernstein J. et al. Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children. J. Am. Soc. Nephrol. 1997; 8: 769-776.
  7. Tune B.M., Mendoza S.A. Treatment of idiopathic nephrоtic syndrome: regimens and outcomes in children and adults. J. Am. Soc. Nephrol. 1997; 8: P. 824-832.
  8. Hodson E.M., Habashy D., Craig J.C. Interventions for idiopathic steroid-resistant nephrotic syndrome in children. Cochrane Database Syst. Rev. (2): CD003594. 2006. Режим доступа: doi: 10.1002/14651858.CD003594.pub3.
  9. Hodson E.M., Willis N.S., Craig J.C. Non-corticosteroid treatment for nephrotic syndrome in children. Cochrane Database Syst. Rev. (1): CD002290. 2008. Режим доступа: doi: 10.1002/14651858.CD002290.pub3.
  10. Ehrich J.H.H. Geerlings C., Zivicnjak M., et al. Steroid-resistant idiopathic childhood nephrosis: overdiagnosed and undertreated. Nephrol. Dial. Transplant. 2007; 22: 2183-2193.
  11. Coppo R. Non-steroidal and non-cytotoxic therapies for nephrotic syndrome. Nephrol. Dial. Transplant. 2008; 1-3. Режим доступа: doi: 10.1093/ndt/gfn211.
  12. Цыгин А.Н., Комарова О.В., Сергеева Т.В. и др. Нефротический синдром. В: Баранов А.А. (ред) Клинические рекомендации по педиатрии. М : Геотар-Медиас. 2005. 107-128.
  13. Gipson D.S., Chin H., Presler T.P. et al. Differential risk of remission and ESRD in childhood FSGS. Pediatr. Nephrol. 2006; 21: 344-349.
  14. Martinelli R., Okumura A.S., Pereira L.J. et al. Primary focal segmental glomerulosclerosis in children: prognostic factors. Pediatr. Nephrol. 2001; 16: 658-661.
  15. Abrantes M.M., Cardoso L.S.B., Lima E.M. et al. Predictive factors of chronic kidney disease in primary focal segmental glomerulosclerosis. Pediatr. Nephrol. 2006; 21: 1003-1012.
  16. K/DOQI. Clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification. Am. J. Kidney Disease 2002; 39: 1-266.
  17. Багдасарова И.В., Фомина С.П. Диагностика и лечение нефротического синдрома у детей. Современная педиатрия 2005; 1 (6): 154-158.
  18. Fomina S., Bagdasarova I. Outcomes of glucocorticoid therapy in the children with steroid sensitive and steroid resistance nephrotic syndrome. WCN2009 Su754. 2009 May; [cited 2009 May 24]. Режим доступа: <http://www.postersessiononline>.eu/aula_poster.asp
  19. Фомина С.П., Багдасарова И.В. Иммуносупрессивная терапия гормонорезистентного нефротического синдрома у детей: алкилирующие агенты. Укр. журнал нефрології та діалізу 2010; 1 (25): 27-33.
  20. Fomina S., Bagdasarova I. Efficiency of Cyclosporin A and Mycophenolate Mofetil in the children with steroid sensitive nephrotic syndrome. WCN2009 Su732. 2009 May; [cited 2009 May 24]. Режим доступa: http://www.postersessiononline.eu/aula_poster.asp
  21. Rice J.A. Mathematical Statistics and Data Analysis. Duxbury Press. 2006. 348-353.
  22. Paik K.H., Lee B.H., Cho H.Y. et al. Primary focal segmental glomerular sclerosis in children: clinical course and prognosis. Pediatr. Nephrol. 2007; 22: 389-395.
  23. Chesney R. The changing face of childhood nephrotic syndrome. Kidney Int. 2004; 66: 1294-1302.
  24. Borges F.F., Shiraichi L., da Silva M.P. et al. Is focal segmental glomerulosclerosis increasing in patients with nephrotic syndrome? Pediatr. Nephrol. 2007; 22: 1309-1313.
  25. Abeyagunawardena A.S., Sebire N.J., Risdon R.A. et al. Predictors of long-term outcome of children with idiopathic focal segmental glomerulosclerosis. Pediatr. Nephrol. 2007; 22: 215-221.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>