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No 3 (2011)
- Year: 2011
- Articles: 15
- URL: https://journals.eco-vector.com/2075-3594/issue/view/6300
Articles
4-10
11-15
16-21
22-25
26-30
31-35
36-42
43-52
HEPATO-RENAL SYNDROME: MODERN OPPORTUNITIES OF THERAPY
Abstract
Aim. Study of efficacy of albimun dialysis with molecular adsorbent recirculation system (MARS) in treatment of type 2 hepatorenal syndrome.
Methods. 25 patients (15 male, 10 female), age 41 - 69 years, with chronic hepatic failure and type 2 hepatorenal syndrome were included into the study. 1st group of patients (n=15) received extended veno-venous haemofiltration and drug treatment, in 2nd group (n=10) albimun dialysis with MARS was also performed.
Results. Drug treatment and extended veno-venous haemofiltration lead to improvement of clinical status, decrease of serum concentration of urea, creatinine, К+, elevation of serum concentration of Na+ and glomerulary filtration rate (GFR). Elevation of systolic blood pressure (SBP) was also observed. In group of patients, who received albimun dialysis with MARS improvement of synthetic function of liver was registered; they also demonstrated higher values of SBP and GFR, than 1st group. 30-day mortality was 73% in 1st group and 40% in 2nd group.
Comclusion. Inclusion into treatment protocol of type 2 hepatorenal syndrome albimun dialysis with MARS leads to improvement of liver synthetic function, decrease of severity of renal failure and 30-day mortality.
Clinical nephrology. 2011;(3):53-57
53-57
Opportunities of healthcare centers in detection of patients with kidney disease and cardiovascular risk
Abstract
Aim. Determination of opportunities of Healthcare centers in revealing and prevention of chronic kidney disease.
Methods. The study was conducted in Healthcare center based in State outpatient clinic #109, Saint-Petersburg. 1422 persons were included into the study and were divided into 2 groups: 1st consisted of patients with chronic kidney disease, 2nd - patients without signs of chronic kidney disease.
Results. Screening in Healthcare center is effective in revealing of patients with arterial hypertension and it's risk factor, as well as patients with chronic kidney disease. Most of the patients with chronic kidney disease have cardiovascular risk factors.
Conclusion. Patients with cardiovascular risk factors, applying to the Healthcare centers, should be screened for markers of chronic kidney disease.
Clinical nephrology. 2011;(3):57-60
57-60
Chronic kidney disease risk factors in development of renal dysfunction in chronic heart failure patients
Abstract
Aim. Determination of prevalence of chronic kidney disease (CKD) and it's risk factors in patients with chronic heart failure (CHF).
Methods. 167 patients (21 male and 146 female, mean age 60,9±11,4 years) with CHF I-IV (NYHA) were included into the study. Risk factors - body mass index (BMI), serum total cholesterol (TC), low density (LDL-C) and high density lipoprotein (HDL-C) cholesterol , triglycerides (TG), uric acid and creatinine level - were determined. Blood pressure (BP) and heart rate (HR) were determined. Glomerular filtration rate (GFR) was assessed by Cockroft-Gault formula.
Results. According to age increase CHF becomes more severe and is associated with GFR fall with simultaneous creatininemia increase. Increase of CHF severity is accompanied with BMI and GFR decrease, as well as with the increase in HR. Higher mean BP is associated with higher creatininemia, low diastolic BP - with decrease in GFR. Rise in serum uric acid level correlates with dislipidemia.
Conclusion. In CHF patients CKD development and progression is associated with risk factor dynamics.
Clinical nephrology. 2011;(3):61-64
61-64
steroid resistant nephrotic syndrome in childhood: Single-centre experience
Abstract
Aim. Assessment of survival of children with steroid-resistant nephrotic syndrome in Ukraine, determination of risk factors for chronic renal failure development.
Methods. Clinical evolution of 646 children with steroid-resistant nephrotic syndrome was performed according to the hospitalization periods (1980 - 2000 and 2001 - 2006).
Results Clinical and morphological dynamics of steroid-resistant nephrotic syndrome in children was detected. In 1980 - 2000 the main risk factors for chronic renal failure development were renal function deterioration in the debut of the diasease and arterial hypertension. In 2001-2006 cumulative risk of chronic renal failure decreased (27,7% vs 39,7% in 1980-2000, p=0,008). In 2001-2006 risk of chronic heart failure became higher in boys aged 3 - 6 years.
Conclusion. Dynamics of clinical and moprphological characteristics and chronic renal failure risk in children with chronic renal failure call for immunosuppressive therapy protocols optimization
Clinical nephrology. 2011;(3):65-69
65-69
70-74
75-78
79-79