Role of R990G polymorphism of calcium-sensing receptor gene in regulation of parathyroid hormone level in children with chronic kidney disease stage III-V
- Авторлар: Molchanova MS1, Tikhomirov EE1, Bykova LP1, Molchanova EA1, Rumyantsev AL1, Valov AL1, Ektov DB1, Ektov VA1, Yurasova Y.B1, Petrosyan EK1, Molchanova MS1, Tikhomirov EE1, Bykova LP1, Molchanova EA1, Rumiantsev AL1, Valov AL1, Ektov DB1, Ektov VA1, Yurasova Y.B1, Petrosian EK1
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Мекемелер:
- Шығарылым: № 1 (2012)
- Беттер: 36-40
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/261654
- ID: 261654
Дәйексөз келтіру
Толық мәтін
Аннотация
Methods. 80 children (44 boys and 36 girls, age 11,5±4,2 (1,6-17,3) years) with CKD stage II - V were included into the study. 40 subjects (14 male, 36 female, age 32,9±11,5 (22-45) years) without CKD served as controls. Presence of A986S, R990G и Q1011E polymorphisms of calcium-sensing receptor gene was assessed. PTH level was determined in all patients: in 70 children (PTH>72 pg/ml) secondary hyperparathyroidism was diagnosed, 10 children has hypoparathyroidism (PTH<62 pg/ml).
Results. Frequency of calcium-sensing receptor gene alleles did not differ significantly between groups of children with hyperparathyroidism, hypoparathyroidism and healthy controls. In children with hypoparathyroidism frequency of G allele and RG990 genotype increased in comparison with control group and children with hypertparahyroidism. G allele frequency was 25% in hypoparathyroidism group, 6,2% in control group (χ2=6,25, р=0,01) and 9,3% in hyperparathyroidism group (χ2=4,33, р=0,04). RG genotype was found in 50% of children with hypoparathyroidism, 12,5% in control group (χ2=7,03, р=0,008) and 18,6% in hyperparathyroidism group (χ2=4,96, р=0,03).
Conclusion. Presence of G990 allele of calcium-sensing receptor gene in children with CKD is associated with lower PTH level and susceptibility to hypoparathyroidism
Негізгі сөздер
Авторлар туралы
M Molchanova
E Tikhomirov
L Bykova
E Molchanova
A Rumyantsev
A Valov
D Ektov
V Ektov
Yu Yurasova
E Petrosyan
M Molchanova
E Tikhomirov
L Bykova
E Molchanova
A Rumiantsev
A Valov
D Ektov
V Ektov
Yu Yurasova
E Petrosian
Әдебиет тізімі
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