Long-term results of coupled plasma filtration adsorption in the treatment of renal transplant ischemia reperfusion injury
- Авторлар: Vatazin AV1, Zulkarnaev AB1, Shahov NL1, Krstich M1, Kantarija RO1
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Мекемелер:
- Шығарылым: № 4 (2015)
- Беттер: 56-61
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/262674
- ID: 262674
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Аннотация
Ischemia reperfusion injury has been an inevitable event accompanying kidney transplantation.
This syndrome is a complex, multicomponent process with the critical role of inflammatory mediators - cytokines -in its pathogenesis. One of the promising treatment modalities able to effectively reduce cytokine concentration is coupled plasma filtration adsorption (CPFA). The first results of the study indicate that the reduction in circulating mediator concentration has a protective effect. We evaluated the long-term outcomes of this method application.
The purpose of the study: Evaluate long-term results of coupled plasma filtration adsorption in the early postoperative period to reduce the severity of ischemic reperfusion injury of the renal transplant.
Patients and methods: Long-term results of renal transplantation in 33 couples of recipients. The patients were divided into two groups: 33 recipients of the study group were treated with CPFA in the immediate postoperative period. In 33 recipients of the comparison group, who received paired kidney transplants, CPFA was not performed. We investigated blood concentrations of creatinine and blood urea, true GFR and 24-hour urine protein at 3, 6 and 12 months after kidney transplantation. Also, protocol kidney transplant biopsies were performed one year after the ART and in cases of graft dysfunction.
Results of the study: Analysis of long-term results showed that one year after transplantation patients, treated with CPFA in the immediate postoperative period, had fewer episodes of acute graft rejection and less severe chronic transplant nephropathy. Graft function in the study group was better: lower levels of azotemia and 24-hour urine protein, higher GFR. Between group differences were greater with increasing length of the postoperative period. Conclusions: Thus, as a result of CPFA in the immediate postoperative period, improvement of function can be expected in the long term, as well as improvement of the prognosis of the graft survival.
This syndrome is a complex, multicomponent process with the critical role of inflammatory mediators - cytokines -in its pathogenesis. One of the promising treatment modalities able to effectively reduce cytokine concentration is coupled plasma filtration adsorption (CPFA). The first results of the study indicate that the reduction in circulating mediator concentration has a protective effect. We evaluated the long-term outcomes of this method application.
The purpose of the study: Evaluate long-term results of coupled plasma filtration adsorption in the early postoperative period to reduce the severity of ischemic reperfusion injury of the renal transplant.
Patients and methods: Long-term results of renal transplantation in 33 couples of recipients. The patients were divided into two groups: 33 recipients of the study group were treated with CPFA in the immediate postoperative period. In 33 recipients of the comparison group, who received paired kidney transplants, CPFA was not performed. We investigated blood concentrations of creatinine and blood urea, true GFR and 24-hour urine protein at 3, 6 and 12 months after kidney transplantation. Also, protocol kidney transplant biopsies were performed one year after the ART and in cases of graft dysfunction.
Results of the study: Analysis of long-term results showed that one year after transplantation patients, treated with CPFA in the immediate postoperative period, had fewer episodes of acute graft rejection and less severe chronic transplant nephropathy. Graft function in the study group was better: lower levels of azotemia and 24-hour urine protein, higher GFR. Between group differences were greater with increasing length of the postoperative period. Conclusions: Thus, as a result of CPFA in the immediate postoperative period, improvement of function can be expected in the long term, as well as improvement of the prognosis of the graft survival.
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Әдебиет тізімі
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