OUTCOMES OF DYSMETABOLIC NEPHROPATHIES: RESULTS OF THE RETROSPECTIVE STUDY


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Aim. Assessment of long-term outcomes of dysmetabolic nephropathy.
Methods. 40 patients (14 male, 26 female, age 16 - 28 years) with dysmetabolic nephropathy in childhood were included into the study. 30 healthy volunteers served as controls. In all patients parameters, characterizing renal function, were determined.
Results. 2 patients demonstrated isolated crystaluria, 21 - signs of dysmetabolic nephropathy, 10 had tubulo-interstitial nephritis, 7 - isolated changes in urinalysis. In comparison with healthy controls, group of patients, who had dysmetabolic nephropathy in childhood, shown decreased tubular water reabsorbtion, elevated uric acid clearance, fractional excretion of uric acid and calcium, and raised urinary concentration of oxalic acid.
Conclusion. Long-term outcomes of dysmetabolic nephropathy are variable and may be considered for long monitoring of signs of chronic kidney disease in this patients.

Bibliografia

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