Features of renal dysfunction in patients with chronic obstructive pulmonary disease

Objective. To study features of renal dysfunction and risk factors for CKD in COPD patients. Materials and methods. 300 inpatient medical records (form 003/y) of the Pulmonary Department of Krasnodar Тен №2 with the verified diagnosis of COPD stages і-iv (76.3% male, mean age 68.51±9.85 years, the average length of the disease 20.9±3.2 years; 23.6% women, mean age 65.95±10,1 years, average length disease 17.2±2.2 years). Estimated glomerular filtration rate (eGFR) was calculated in all patients with the use of the CKD-Ері equation. results. Moderate reduction of eGFRCKD-EPI 89-60 ml/min/i,73m 2 (37.з%), hyperfiltration was found in 22% of patients, eGFRCKD-EPI reduction ranged from 59 to 45 ml/min/1,73m 2 was detected in 26.7% of patients and eGFRCKD-EPI of 44-30 ml/min/1,73m 2 - in 3.3% of patients. There was a high prevalence of potentially modifiable CKD risk factors: ELEVATED CRP LEVELS - in 100% of patients, smoking - in 92%, age 65 years - in 78.6%, hypertension - in 65.6%, genitourinary diseases - in 53 3%, excess BMI and obesity -in 36%, long-term use of NSAIDS - in 36%, impaired carbohydrate metabolism - in 17.6%. Conclusions. The high prevalence of risk factors for CKD and reduced eGFRCKD-EPI in COPD patients shows that special attention to renal function should be paid in these patients.

chronic obstructive pulmonary disease, chronic kidney disease, risk factors, decreased glomerular filtration rate