Cardio-renal interrelations in patients with diabetes mellitus type 2 and obesity


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Aim. Assessment of interrelations of myocardial remodeling with obesity and development of diabetic nephropathy in patients with dibetes mellitus type 2. (DM 2)
Methods. 84 patients with DM 2 (38 male, 46 female, mean age 58,1±6,3 лет) were included into the study. Body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio were measured. Serum creatinine, uric acid, lipid metabolism parameters, adipokines (leptin, adiponectin) levels were determined. Kidney disease severity was assessed according to glomerular filtration rate (GFR) and albuminuria. Left ventricular myocardial mass (LVM) was measured according to echocardiography. Patients were divided into groups according to h DM duration <5 years and >5 years as well as witth BMI <30 kg/m2 and >30 kg/m2.
Results. In patients with DM duration > 5 years, but not in with DM duration < 5 years, t frequency of left ventricular hypertrophy and kidney disease severity increased according to the obesity enhancemen. Antropometric parameters, uricemia and glycated hemoglobin level were determinants of left ventricular hypertrophy and diabetic nephropathy development.
Conclusion. In diabetes mellitus type 2 obesity favores development of left ventricular hypertrophy and diabetic nephropathy development as clue components of cardiorenal syndrome.

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