Izmeneniya urovney belkov krovi pri sovmestnom vozdeystviiantiortostaticheskoy gipokinezii i blokatora k+/h+AT Fazy omeprazola


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Abstract

Blood concentrations of α1-antitrypsin (α1-AT), α1-acid glycoprotein (α1-AGP), α2-macroglobulin (α2-M), and haptoglobin
(Hp) were measured in 8 test subjects who consecutively participated to two series of head down tilt (HDT -15o) study: HDT
without the use of pharmaceutical agents (control series) and HDT after the intake of K+H+ATPase inhibitor Omeprazole (Omez)
in therapeutic doses. The results showed that in contrast to control series with pure HDT, combined influence of HDT and
Omeprazole caused the decrease in α1-AT and Hp blood levels (difference between series showing statistical reliability for Hp).
HDT conditions caused the decrease in α1-AGP and α2-M both in the presence and absence of Omeprazole. The reason for
decrease in protease inhibitors (α1-AT and α2-M) in this study could be the release of lysosomal proteases from leukocytes
while Omeprazole seemed to enhance this effect. An abrupt decline of Hp concentration in HDT series with Omeprazole suggests
the lowering of erythrocyte membrane stability caused by this medicine. The results obtained show the possibility that
Omeprazole can modulate postural and gravitational effects on blood protein concentrations

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