ROLE OF HYDROGEN PEROXIDE IN THE MYELOPEROXIDE-DEPENDENT ANTIMICROBIAL ACTIVITY OF NEUTROPHILS


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The paper considers the role of hydrogen peroxide (H 2O 2) in the myeloperoxidase-dependent activity of major human protective cells, such as neutrophil leukocytes, in the formation of the strong bactericidal agent hypochlorous acid and its ionic form (HOCl/OCl -). Myeloperoxidase is present in large amounts in the specialized antimicrobial organelles — peroxidasosomes. It catalyzes reduction of H 2O 2 to H 2O, by oxidizing to the active enzyme form that is able to oxidize Cl - to HOCl/OCl - in a dielectric fashion. After fusion, peroxidasosomes and phagosomes receive a variety of cytotoxic agents, including myeloperoxidase, which is formed by the oxidase system of the phagosomal membrane of H 2O 2 /Cl - that enters through the chloride anion channels of the membranes of phagosomes. The phasosomal generation of HOCl/OCT that eliminates and destroys pathogenic microorganisms is of key value for the optimal antimicrobial activity of neutrophils.

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作者简介

V. ROGOVIN

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences

Email: viknik-fomin@mail.ru
Moscow

R. MURAVYEV

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences

Moscow

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