ROLE OF HYDROGEN PEROXIDE IN THE MYELOPEROXIDE-DEPENDENT ANTIMICROBIAL ACTIVITY OF NEUTROPHILS
- Autores: ROGOVIN V.V1, MURAVYEV R.A1
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Afiliações:
- N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
- Edição: Nº 5 (2012)
- Páginas: 62-65
- Seção: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/276110
- ID: 276110
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Resumo
The paper considers the role of hydrogen peroxide (H 2O 2) in the myeloperoxidase-dependent activity of major human protective cells, such as neutrophil leukocytes, in the formation of the strong bactericidal agent hypochlorous acid and its ionic form (HOCl/OCl -). Myeloperoxidase is present in large amounts in the specialized antimicrobial organelles — peroxidasosomes. It catalyzes reduction of H 2O 2 to H 2O, by oxidizing to the active enzyme form that is able to oxidize Cl - to HOCl/OCl - in a dielectric fashion. After fusion, peroxidasosomes and phagosomes receive a variety of cytotoxic agents, including myeloperoxidase, which is formed by the oxidase system of the phagosomal membrane of H 2O 2 /Cl - that enters through the chloride anion channels of the membranes of phagosomes. The phasosomal generation of HOCl/OCT that eliminates and destroys pathogenic microorganisms is of key value for the optimal antimicrobial activity of neutrophils.
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Sobre autores
V. ROGOVIN
N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: viknik-fomin@mail.ru
Moscow
R. MURAVYEV
N.N. Semenov Institute of Chemical Physics, Russian Academy of SciencesMoscow
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