ACQUIRED RESISTANCE OF THE PATHOGENS OF NOSOCOMIAL PYOSEPTIC INFECTIONS TO DISINFECTANTS AND ANTISEPTICS

Objective. To study the susceptibility of different types of pathogens of nosocomial pyoseptic infections (PSI) to different groups of disinfectants and skin antiseptics. Materials and methods. The susceptibility of 238 PSI pathogen strains of 13 species isolated from the patients and hospital environment of two obstetric, three intensive care, and one therapeutic hospitals was studied on the test surfaces (glass, metal, plastic, wood, and oilcloth) and in solution. Results. Klebsiella pneumoniae and Streptococcus haemolyticus, which had been isolated at an obstetric hospital, were experimentally found to be susceptible to 13 skin antiseptics in the hygienic treatment of the hands artificially contaminated with the study microorganisms. On the test surfaces, the proportion of nosocomial PSI pathogen strains that were resistant and incompletely susceptible to disinfectants was 1.3±0.7 and 14.7±2.3%, respectively. In the solution, that of the strains was 2.6±1.8 and 2.6±1.8%, respectively. The summary index of resistance and incomplete susceptibility for nosocomial PSI pathogens to disinfectants on the test surfaces and in the solution was 13.7±1.9 per 100 strains. Conclusion. Acquired resistance and incomplete susceptibility to the agents containing quaternary ammonium compounds most commonly form in Pseudomonas аeruginosa, K. рneumoniaе, Staphylococcus epidermidis and S. haemolyticus in the units of therapeutic-and-prophylactic institutions where PSI cases are notified. The PSI pathogens more frequently become resistant to skin antiseptics that are based on water or that contain ethyl or isopropyl alcohol with its low (less than 58%) content.

nosocomial pyoseptic infection pathogens, resistance to disinfectants and antiseptics