Efficiency of antiviral therapy for chronic hepatitis c in patients with undifferentiated connective tissue dysplasia
- Авторлар: Orlova S.N1, Baskhanova M.V1,2
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Мекемелер:
- Ivanovo State Medical Academy, Ministry of Health of Russia
- Republican Clinical Center of Communicable Diseases
- Шығарылым: Том 9, № 2 (2019)
- Беттер: 61-67
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/287327
- DOI: https://doi.org/10.18565/epidem.2019.9.2.61-7
- ID: 287327
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Objective. To determine the impact of undifferentiated connective tissue dysplasia (UCTD) on the efficiency of antiviral therapy (AVT) in patients with chronic hepatitis C (CHC). Subjects and methods. The investigation enrolled 71 patients receiving AVT for CHC, who were divided into 2 groups: 1) 48patients with signs of UCTD; 2) 23 patients without UCTD. Results. During dual AVT, a sustained virological response (SVR) was achieved in 75 and 91.3% in Groups 1 and 2, respectively. Patients with genotype 1 were recorded to have SVR in 64% cases in Group 1 and in 84.6% in Group 2. In patients with HCV genotypes 2 and 3, the achievement of SVR was even higher: in 86.9 and 100% of cases in Groups 1 and 2, respectively. Conclusion. The efficiency of AVT for CHC is associated with the presence of dysplastic manifestations in the patient. Dual AVT leads to SVR in 87% of the patients with chronic hepatitis C caused by HCV genotypes 2 and 3 and by UCTD and in 64% of those who have HCV genotype 1. There is 100% SVR in non- UCTD patients with HCV caused by HCV genotypes 2 and 85% SVR in those with HCV genotype 1. The presence of UCTD substantially affects the frequency and severity of adverse events occurring during AVT.
Толық мәтін
Авторлар туралы
S. Orlova
Ivanovo State Medical Academy, Ministry of Health of Russia
Email: orloff3.dok@mail.ru
Postgraduate Student, Department of Infectious Diseases, Epidemiology and Dermatovenereology Ivanovo, Russia
M. Baskhanova
Ivanovo State Medical Academy, Ministry of Health of Russia; Republican Clinical Center of Communicable Diseases
Email: marh.74@mail.ru
Postgraduate Student, Department of Infectious Diseases, Epidemiology and Dermatovenereology Ivanovo, Russia; Groznyi, Russia
Әдебиет тізімі
- Мухин H.A., Абдурахманов Д.Т., Розина Т.П., Лопаткина Т.Н., Никулкина Е.Н., Старостина Е.Е., Сидорова Е.И. Новые возможности противовирусной терапии хронического гепатита С у больных с неблагоприятными прогностическими факторами. Клиническая гепатология 2013; 1: 28-36.
- Знойко О.О., Дудина К.Р., Козина А.Н., Ленкова Д.О., Калинина О.В., Ющук Н. Д. Подводные камни при лечении больных хроническим гепатитом С, инфицированных генотипами 2 и 3 вируса гепатита С. Инфекционные болезни. Новости. Лечение. Обучение 2016; (1): 108-13.
- Сапронов Г.В., Николаева Л.И. Новые перспективы персонифицированной терапии хронического вирусного гепатита С Эпидемиология и инфекционные болезни 2013; (3): 27-36.
- Озолиня А.Ж. Биохимические аспекты реактивности соединительной ткани. Рига: Зинатне, 1986. 83 с.
- Чемоданов В.В., Краснова Е.Е. Принципы диагностики и тактика сопровождения детей с соединительнотканными дисплазиями. Вестник Ивановской медицинской академии 2015; 20(4): 5-14.
- Маколкин В.И., Подзолков В.И., Родионов А.В., Шеяно в М.В., Подзолков В.И., Родионов А.В., Шеянов М., Самойленко В.В., Напалков Д.А. Полиморфизм клинических проявлений синдрома соединительнотканной дисплазии. Тер. архив 2004; (11): 80-3.
- Martinez S.M., Crespo G., Navasa M., Forns X. Noninvasive assessment of liver fibrosis. Hepatology 2011; 53(1): 325-35.
- Loeys B.L., Dietz H.C., Braverman A.C. The revised Ghent nosology for the Marfan symdrome. J. Med. Genet. 2010; 47(7): 476-85.
- Ивашкин В.Т., Ющук Н.Д., Маевская М.В. Рекомендации по диагностике и лечению взрослых больных гепатитом С. Рос. журн. гастроэнтерологии, гепатологии и колопроктологии 2013; (2): 41-70.
- EASL. Recommendations on Treatment of Hepatitis 2014. htpp://files.easl.eu/easl-recommendations-on-trearment-of-hepatitis-C.pdf.
- EASL. Recommendations on Treatment of Hepatitis C 2015. J. Gastroenterology 2015; 63(1): 199-236.
- Desmet V.J., Gerber M., Hoofnagle J.H., Manns M., Scheuer P.J. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; 19: 1513-20.
- Яковлев В.М., Глотов А.В., Ягода А.В. Иммунопатологические синдромы при наследственной дисплазии соединительной ткани. Ставрополь, 2005. 234 с.
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