A case of septic salmonellosis with damage to the central nervous system in HIV-infected patient

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Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. Analysis of a case of septic salmonellosis with damage to the central nervous system in a HIV infected patient.

Materials and methods. The data of clinical, laboratory and instrumental diagnostic methods in HIV-infected patient with a septic salmonellosis, who was being treated at the City Infectious Diseases Clinical Hospital № 1 in Novosibirsk, were analyzed.

Results. The clinical course of salmonellosis against the background of severe immunodeficiency was characterized by a rapid transition from the gastrointestinal to the septic form with the development of damage to the central nervous system on the 5th day of hospitalization. The choice of antibacterial therapy tactics was complicated by the presence of resistance of blood-isolated S. enteritidis to ciprofloxacin and amikacin. Despite the resumption of antiretroviral therapy and ongoing antibacterial (taking into account sensitivity) and pathogenetic therapy, the patient’s condition could not be stabilized. Irreversible damage by S. enteritidis to the central nervous system and kidneys against the background of severe immunodeficiency led to severe impairment of vital functions followed by death.

Conclusion. When diagnosing salmonellosis in patients with HIV infection, awareness in terms of the high risk of developing generalized forms of the disease is necessary. In real clinical practice, a study of the drug resistance profile of Salmonella is required to select effective antibacterial therapy.

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Авторлар туралы

Dmitry Kapustin

Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1

Хат алмасуға жауапты Автор.
Email: dmitrij_kapustin_1991@inbox.ru
ORCID iD: 0000-0002-7060-4710

Cand. Med. Sci., Assistant, Department of Infectious Diseases, Novosibirsk State Medical University

Ресей, Novosibirsk; Novosibirsk

Elena Krasnova

Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1

Email: krasnova-inf@rambler.ru
ORCID iD: 0000-0003-3168-9309

МD, Professor, Head, Department of Infectious Diseases, Novosibirsk State Medical University

Ресей, Novosibirsk; Novosibirsk

Natalia Khokhlova

Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1

Email: Novosibirsk.talitas@bk.ru
ORCID iD: 0000-0003-4497-3173

Cand. Med. Sci., Associate Professor, Associate Professor, Department of Infectious Diseases, Novosibirsk State Medical University

Ресей, Novosibirsk; Novosibirsk

Svetlana Demchenko

City Infectious Diseases Clinical Hospital № 1

Email: gikb1@yandex.ru

Infectious Disease Doctor

Ресей, Novosibirsk

Olga Shishkova

City Infectious Diseases Clinical Hospital № 1

Email: gikb1@yandex.ru

Pathologist

Ресей, Novosibirsk

Nadezhda Kriklivaya

State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: kriklivaya_np@vector.nsc.ru

Research Assistant, Department of Retroviruses

Ресей, Koltsovo

Tatiana Nalimova

State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: nalimova_tm@vector.nsc.ru
ORCID iD: 0000-0001-8408-0930

Junior Researcher, Department of Retroviruses, Postgraduate Student

Ресей, Koltsovo

Natalya Gashnikova

State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: ngash@vector.nsc.ru
ORCID iD: 0000-0002-0891-0880

Cand. Med. Sci., Head, Department of Retroviruses

Ресей, Koltsovo

Larisa Pozdnyakova

City Infectious Diseases Clinical Hospital № 1

Email: gikb1@yandex.ru

Cand. Med. Sci., Chief Physician

Ресей, Novosibirsk

Әдебиет тізімі

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1. JATS XML
Жүктеу
2. Fig. 1. Morphological picture of central nervous system damage in HIV infected patient with a septic salmonellosis

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Метадеректер
3. Fig. 2. Morphological picture of kidney damage in Hiv-infected patient with a septic salmonellosis

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