A case of septic salmonellosis with damage to the central nervous system in HIV-infected patient
- 作者: Kapustin D.V.1,2, Krasnova E.I.1,2, Khokhlova N.I.1,2, Demchenko S.V.2, Shishkova O.M.2, Kriklivaya N.P.3, Nalimova T.M.3, Gashnikova N.M.3, Pozdnyakova L.L.2
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隶属关系:
- Novosibirsk State Medical University
- City Infectious Diseases Clinical Hospital № 1
- State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- 期: 卷 13, 编号 4 (2023)
- 页面: 87-92
- 栏目: Clinical Notes
- URL: https://journals.eco-vector.com/2226-6976/article/view/625536
- DOI: https://doi.org/10.18565/epidem.2023.13.4.87-92
- ID: 625536
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详细
Objective. Analysis of a case of septic salmonellosis with damage to the central nervous system in a HIV infected patient.
Materials and methods. The data of clinical, laboratory and instrumental diagnostic methods in HIV-infected patient with a septic salmonellosis, who was being treated at the City Infectious Diseases Clinical Hospital № 1 in Novosibirsk, were analyzed.
Results. The clinical course of salmonellosis against the background of severe immunodeficiency was characterized by a rapid transition from the gastrointestinal to the septic form with the development of damage to the central nervous system on the 5th day of hospitalization. The choice of antibacterial therapy tactics was complicated by the presence of resistance of blood-isolated S. enteritidis to ciprofloxacin and amikacin. Despite the resumption of antiretroviral therapy and ongoing antibacterial (taking into account sensitivity) and pathogenetic therapy, the patient’s condition could not be stabilized. Irreversible damage by S. enteritidis to the central nervous system and kidneys against the background of severe immunodeficiency led to severe impairment of vital functions followed by death.
Conclusion. When diagnosing salmonellosis in patients with HIV infection, awareness in terms of the high risk of developing generalized forms of the disease is necessary. In real clinical practice, a study of the drug resistance profile of Salmonella is required to select effective antibacterial therapy.
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作者简介
Dmitry Kapustin
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
编辑信件的主要联系方式.
Email: dmitrij_kapustin_1991@inbox.ru
ORCID iD: 0000-0002-7060-4710
Cand. Med. Sci., Assistant, Department of Infectious Diseases, Novosibirsk State Medical University
俄罗斯联邦, Novosibirsk; NovosibirskElena Krasnova
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
Email: krasnova-inf@rambler.ru
ORCID iD: 0000-0003-3168-9309
МD, Professor, Head, Department of Infectious Diseases, Novosibirsk State Medical University
俄罗斯联邦, Novosibirsk; NovosibirskNatalia Khokhlova
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
Email: Novosibirsk.talitas@bk.ru
ORCID iD: 0000-0003-4497-3173
Cand. Med. Sci., Associate Professor, Associate Professor, Department of Infectious Diseases, Novosibirsk State Medical University
俄罗斯联邦, Novosibirsk; NovosibirskSvetlana Demchenko
City Infectious Diseases Clinical Hospital № 1
Email: gikb1@yandex.ru
Infectious Disease Doctor
俄罗斯联邦, NovosibirskOlga Shishkova
City Infectious Diseases Clinical Hospital № 1
Email: gikb1@yandex.ru
Pathologist
俄罗斯联邦, NovosibirskNadezhda Kriklivaya
State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: kriklivaya_np@vector.nsc.ru
Research Assistant, Department of Retroviruses
俄罗斯联邦, KoltsovoTatiana Nalimova
State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: nalimova_tm@vector.nsc.ru
ORCID iD: 0000-0001-8408-0930
Junior Researcher, Department of Retroviruses, Postgraduate Student
俄罗斯联邦, KoltsovoNatalya Gashnikova
State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: ngash@vector.nsc.ru
ORCID iD: 0000-0002-0891-0880
Cand. Med. Sci., Head, Department of Retroviruses
俄罗斯联邦, KoltsovoLarisa Pozdnyakova
City Infectious Diseases Clinical Hospital № 1
Email: gikb1@yandex.ru
Cand. Med. Sci., Chief Physician
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