A case of septic salmonellosis with damage to the central nervous system in HIV-infected patient
- Authors: Kapustin D.V.1,2, Krasnova E.I.1,2, Khokhlova N.I.1,2, Demchenko S.V.2, Shishkova O.M.2, Kriklivaya N.P.3, Nalimova T.M.3, Gashnikova N.M.3, Pozdnyakova L.L.2
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Affiliations:
- Novosibirsk State Medical University
- City Infectious Diseases Clinical Hospital № 1
- State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- Issue: Vol 13, No 4 (2023)
- Pages: 87-92
- Section: Clinical Notes
- URL: https://journals.eco-vector.com/2226-6976/article/view/625536
- DOI: https://doi.org/10.18565/epidem.2023.13.4.87-92
- ID: 625536
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Abstract
Objective. Analysis of a case of septic salmonellosis with damage to the central nervous system in a HIV infected patient.
Materials and methods. The data of clinical, laboratory and instrumental diagnostic methods in HIV-infected patient with a septic salmonellosis, who was being treated at the City Infectious Diseases Clinical Hospital № 1 in Novosibirsk, were analyzed.
Results. The clinical course of salmonellosis against the background of severe immunodeficiency was characterized by a rapid transition from the gastrointestinal to the septic form with the development of damage to the central nervous system on the 5th day of hospitalization. The choice of antibacterial therapy tactics was complicated by the presence of resistance of blood-isolated S. enteritidis to ciprofloxacin and amikacin. Despite the resumption of antiretroviral therapy and ongoing antibacterial (taking into account sensitivity) and pathogenetic therapy, the patient’s condition could not be stabilized. Irreversible damage by S. enteritidis to the central nervous system and kidneys against the background of severe immunodeficiency led to severe impairment of vital functions followed by death.
Conclusion. When diagnosing salmonellosis in patients with HIV infection, awareness in terms of the high risk of developing generalized forms of the disease is necessary. In real clinical practice, a study of the drug resistance profile of Salmonella is required to select effective antibacterial therapy.
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About the authors
Dmitry V. Kapustin
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
Author for correspondence.
Email: dmitrij_kapustin_1991@inbox.ru
ORCID iD: 0000-0002-7060-4710
Cand. Med. Sci., Assistant, Department of Infectious Diseases, Novosibirsk State Medical University
Russian Federation, Novosibirsk; NovosibirskElena I. Krasnova
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
Email: krasnova-inf@rambler.ru
ORCID iD: 0000-0003-3168-9309
МD, Professor, Head, Department of Infectious Diseases, Novosibirsk State Medical University
Russian Federation, Novosibirsk; NovosibirskNatalia I. Khokhlova
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
Email: Novosibirsk.talitas@bk.ru
ORCID iD: 0000-0003-4497-3173
Cand. Med. Sci., Associate Professor, Associate Professor, Department of Infectious Diseases, Novosibirsk State Medical University
Russian Federation, Novosibirsk; NovosibirskSvetlana V. Demchenko
City Infectious Diseases Clinical Hospital № 1
Email: gikb1@yandex.ru
Infectious Disease Doctor
Russian Federation, NovosibirskOlga M. Shishkova
City Infectious Diseases Clinical Hospital № 1
Email: gikb1@yandex.ru
Pathologist
Russian Federation, NovosibirskNadezhda P. Kriklivaya
State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: kriklivaya_np@vector.nsc.ru
Research Assistant, Department of Retroviruses
Russian Federation, KoltsovoTatiana M. Nalimova
State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: nalimova_tm@vector.nsc.ru
ORCID iD: 0000-0001-8408-0930
Junior Researcher, Department of Retroviruses, Postgraduate Student
Russian Federation, KoltsovoNatalya M. Gashnikova
State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: ngash@vector.nsc.ru
ORCID iD: 0000-0002-0891-0880
Cand. Med. Sci., Head, Department of Retroviruses
Russian Federation, KoltsovoLarisa L. Pozdnyakova
City Infectious Diseases Clinical Hospital № 1
Email: gikb1@yandex.ru
Cand. Med. Sci., Chief Physician
Russian Federation, NovosibirskReferences
- Сальмонеллез у взрослых: Клинические рекомендации. Клинические рекомендации. М.: Министерство здравоохранения Российской Федерации, 2021. https://legalacts.ru/doc/klinicheskie-rekomendatsii-salmonellez-u-vzroslykh-utv-minzdravom-rossii/ [Salmonellosis in adults: National clinical guidelines]. Moscow: Ministry of Health of the Russian Federation, 2021. (In Russ.). https://legalacts.ru/doc/klinicheskie-rekomendatsii-salmonellez-u-vzroslykh-utv-minzdravom-rossii/
- Centers for Disease Control and Prevention. Multistate Outbreak of Salmonella Tennessee Infections Linked to Peanut Butter (Final Update). https://www.cdc.gov/salmonella/2007/peanut-butter-3-7-2007.html
- Miller S.I., Pegues D.A. Salmonella species, including Salmonella typhi. In: Mandell G.L., Bennett J.E., Dolin R. eds. Principles and Practice of Infectious Diseases. 9th ed. Philadelphia: Churchill Livingstone, 2010: 2887–903,
- Mendes M.M., Carminatti M., Pinheiro H.S. Severe sepsis from a Ciprofloxacin resistant salmonellosis in a kidney transplant recipient. J. Bras. Nefrol. 2017; 39(1): 82–5. doi: 10.5935/0101-2800.20170014
- Bay C., Jofré M., Kuzmanic D., Aguirre C., Gutiérrez V. Meningitis por Salmonella Enteritidis en un lactante. Comunicación de un caso y revisión de la literatura [Salmonella Enteritidis meningitis in an infant. Case report and literature review]. Rev. Chilena Infectol. 2020; 37(4): 470–6. doi: 10.4067/S0716-10182020000400470. PMID: 3339966
- Piggott D.A., Carroll K.C., Lim M., Melia M.T. Nontyphoidal Salmonellosis, Human Immunodeficiency Virus Infection, and Ischemic Stroke. Open Forum Infect. Dis. 2016; 3(2): ofw104. doi: 10.1093/ofid/ofw104
- Инфекционные болезни: национальное руководство. 3-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 2021. 1104 с. doi: 10.33029/9704-6122-8-INB-2021-1-1104 [Infectious diseases: National Guidelines]. 3th ed. Moscow: GEOTAR-Media, 2021. 1104 р. (In Russ.) doi: 10.33029/9704-6122-8-INB-2021-1-1104.
- ВИЧ-инфекция у взрослых: Клинические рекомендации. М.: Министерство здравоохранения Российской Федерации, 2020. http://rushiv.ru/wp-content/uploads/2022/11/KR79.pdf [HIV infection in adults: Сlinical guidelines]. Moscow: Ministry of Health of the Russian Federation, 2020. (In Russ.). http://rushiv.ru/wp-content/uploads/2022/11/KR79.pdf
- ВИЧ-инфекция в Российской Федерации на 31 декабря 2021 г.: ФБУН Центральный НИИ эпидемиологии. http://www.hivrussia.info/wp-content/uploads/2022/03/Spravka-VICH-v-Rossii-na-31.12.2021-g..pdf [VICH-v-Rossii-na-31.12.2021-g]. Central Research Institute of Epidemiology. (In Russ.). http://www.hivrussia.info/wp-content/uploads/ 2022/03/Spravka-VICH-v-Rossii-na-31.12.2021-g..pdf
- Crump J.A., Sjölund-Karlsson M., Gordon M.A., Parry C.M. Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections. Clin. Microbiol. Rev. 2015; 28(4): 901–37. doi: 10.1128/CMR.00002-15
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