Laboratory evaluation of erysipelatous inflammation

Objective. To study the association of clinical and laboratory parameters to specify the pattern of adaptation mechanisms in erysipelatous inflammation. Materials and methods. Thirty-five 34- to 65-year-old patients diagnosed with moderate erysipelas of the lower extremity were examined. Blood biochemical parameters, the aggregatory activity of red blood cells and von Willebrand factor, a marker of vascular wall lesion, were studied at disease onset (days 1-4) and during convalescence (days 8-12 and 14-21 of the disease). Results. The conductor of hemorrhagic disorders in erysipelas is the red cell component of hemostasis and the endothelium of blood vessels. Hemorrhagic disorders are accompanied by high von Willebrand factor levels and enhanced red blood cell aggregation induced by LaCl3. The described changes in the functional properties of red blood cells develop in unison with suppressed metabolic processes detectable by conventional biochemical tests. Macroenergy blocking (conventionally normal AST values (mean 29.6 IU/l) during hyperthermia from 39 to 40 °C) is attended by the inhibition of oxidation of the key metabolic substrate glucose. The low level of alkaline phosphatase is a biochemical indicator of worsening of all fluid transmembrane transfers and currents and its least values (40-60 IU/l) are encountered in patients with the most pronounced swelling of the affected extremity and chronic lymphovenous insufficiency. Besides, both the protein potential and protein-synthesizing function of the liver are damaged in patients with erysipelas.

erysipelas, ß-hemolytic streptococcus, thermogenesis, gluconeogenesis, red blood cell aggregation, protamine sulfate, lanthanum chloride, ADP, von Willebrand factor, hypoproteinemia, hypoalbuminemia, transaminases, enzymatic homeostasis, adaptive enzymemia