Deficiencies of magnesium and pyridoxine and the pathogenesis of the metabolic syndrome


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Abstract

Metabolic syndrome (MS) represents a set of metabolic abnormalities that increase the risk of diabetes, cardiovascular and cerebrovascular disease. The components of MS are abdominal obesity, hypertension, disturbances of lipid and carbohydrate metabolism. The pathogenesis of the MS involves complex disorders of carbohydrate and fat metabolism caused by physical inactivity, a load of bad habits as well as by macro- and micronutrient imbalances in diet. Magnesium is one of the main factors supporting the physiological metabolism of sugars and fats as magnesium ion is required for the active sites of a number of enzymes. The paper presents the results of a systematic analysis of the molecular mechanisms of effects on magnesium characteristic of MS disorders of carbohydrate and fat metabolism. The results of experimental and clinical research and the evidence-based data indicate feasibility of using organic salts of magnesium with pyridoxine in the prevention and treatment of MS.

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About the authors

Olga A. Gromova

Ivanovo state medical academy

Email: unesco.gromova@gmail.com
MD, professor of the Department of pharmacology and clinical pharmacology

Alla G. Kalacheva

Ivanovo state medical academy

PhD, associated professor of the Department of pharmacology and clinical pharmacology

Ivan Yu. Torshin

Moscow institute of physics and technology (state university)

candidate of physico-mathematical sciences, associate professor of the Department of intelligent systems

Tatiana R. Grishina

Ivanovo state medical academy

MD, professor, head of the Department of pharmacology and clinical pharmacology

Natalia I. Tapilskaya

Saint-Petersburg State pediatric medical university

MD, professor of the Department of obstetrics and gynecology

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