Contribution of systemic inflammation to the development of vascular remodeling in patients with chronic kidney disease and sarcopenia

The aim: to study the features of vascular blood flow, cardiohemodynamics and cardiovascular remodeling in patients with chronic kidney disease (CKD) stages 3A-5D, depending on the clinical parameters and the severity of CKD, as well as the identification of the relationship between the level of interleukin-6 (IL-6) in the blood serum with the discussed parameters. Material and methods. The study included 80 patients (34 men and 46 women; average age 58,9±13,1 years) with CKD stages 3A-5D. The cohort of patients included in the study was divided into two groups: the first (pre-dialysis) group included 40 patients with CKD stages 3A-5, the second (dialysis) group included 40 patients with CKD 5D stages receiving treatment with programmed hemodialysis. Results. In the general cohort of patients, the level of IL-6 was higher than normal values in 85% of cases (in group 1 - in 92,5% of patients, in group 2 - in 77,5% of patients). The increased level of IL-6 in the pre-dialysis group was more common and amounted to 13,1±0,9 vs 24,5±3,8 pg/ml in the 2nd group. The prevalence of sarcopenia in the 1st group was 12,5%, and in the 2nd group - 42,5%. It was found that renal blood flow in all vascular zones, from the orifices of the renal arteries to the interlobular zones, was significantly reduced in group 2 compared with group 1. At the same time, an increase in IL-6 was associated with an increase in blood flow velocity in interlobular arteries and with an increase in the thickness of the common carotid artery intima-media complex. Conclusion. IL-6 makes a significant contribution to the progression of vascular remodeling, as well as the development of sarcopenia in patients with CKD stages 3A-5D.

systemic inflammation, vascular remodeling, chronic kidney disease, sarcopenia, interleukin-6