Role of visceral obesity in the progression of main arteries rigidity in chronic heart failure patients
- Authors: Statsenko M.E.1, Derevyanchenko M.V.1, Fabritskaya S.V.1, Ryndina Y.A.1, Streltsova A.M.1
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Affiliations:
- Volgograd State Medical University of the Ministry of Healthcare of Russia
- Issue: Vol 9, No 9 (2023)
- Pages: 70-78
- Section: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/626131
- DOI: https://doi.org/10.18565/therapy.2023.9.70-78
- ID: 626131
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Abstract
Obesity is one of the leading risk factors for chronic heart failure (CHF) development and progression.
The aim: to estimate the role of visceral obesity in the progression of rigidity of main arteries in CHF patients.
Material and methods. 165 patients with CHF stages I–IIA, FC I–III, aged 40–65 years were examined. They were randomized into three groups: 1st – with CHF and normal BMI (n=55), 2nd – with CHF and excess BMI (n=53), 3rd – with CHF and obesity of 1–2nd degree (n=57). Patients underwent a clinical examination, BMI calculation, measurements of waist circumference (WC), hip circumference (HC), waist/hip width measurement, bioimpedance measurements, also thickness of epicardial adipose tissue (EAT) was assessed using EchoCG, pulse wave velocity through elastic and muscular vessels (PWVe and PWVm), serum levels of leptin and adiponectin were identified.
Results. A high incidence of abdominal obesity, an increase in visceral fat content and an increase in EAT thickness among patients with excess BMI and obesity were revealed. In the group of patients with CHF and obesity, PWVe was significantly higher – 10,8 [9,2; 12,9] m/s. In group 3, patients with PWVe >10 m/s were significantly more common – 82% versus 57% and 65% in groups 1 and 2, respectively. Significant correlations were established between PWVe and WC (r=0,42), WC/HC (r=-0,44), PWVe and BMI (r=0,38), PWWm and WC (r=0,40), PWWm and WC/TB (r=-0,42), PWWm and BMI (r=0,32) among patients with CHF and obesity. When assessing the dependence of PWVe on the percentage of visceral fat and PWEv on the thickness of EAT, a linear regression dependence and a high-close correlation were obtained. In the 3rd group, statistically significant correlations were revealed between PWVe and the concentration of leptin and (r=0,58), PWVe and the level of adiponectin (r=-0,76). A statistically significant correlation was found between EAT thickness and leptin level (r=0,62), EAT thickness and adiponectin level (r=-0,56).
Conclusion. Reliable associations between the severity of visceral obesity and indexes of vascular wall elasticity reflect the important pathogenetic role of visceral adipose tissue in the development and progression of arterial stiffness in patients with CHF.
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About the authors
Mikhail E. Statsenko
Volgograd State Medical University of the Ministry of Healthcare of Russia
Author for correspondence.
Email: mestatsenko@rambler.ru
ORCID iD: 0000-0002-3306-0312
MD, Professor, Vice-Rector for Research Work, Head of the Department of Internal Medicine
Russian Federation, VolgogradMaria V. Derevyanchenko
Volgograd State Medical University of the Ministry of Healthcare of Russia
Email: derevjanchenko@gmail.com
ORCID iD: 0000-0002-6232-4583
MD, Professor of the Department of Internal Medicine
Russian Federation, VolgogradSvetlana V. Fabritskaya
Volgograd State Medical University of the Ministry of Healthcare of Russia
Email: lanabelenkova@mail.ru
ORCID iD: 0000-0002-5736-2235
PhD in Medical Sciences, Associate Professor of the Department of Internal Medicine
Russian Federation, VolgogradYulia A. Ryndina
Volgograd State Medical University of the Ministry of Healthcare of Russia
Email: rindina91@yandex.ru
ORCID iD: 0000-0002-9351-3002
Postgraduate Student of the Department of Internal Medicine
Russian Federation, VolgogradAnastasia M. Streltsova
Volgograd State Medical University of the Ministry of Healthcare of Russia
Email: nastyc03@mail.ru
ORCID iD: 0000-0001-9016-3011
Assistant at the Department of Internal Medicine
Russian Federation, VolgogradReferences
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