New possibilities of combination drugs in the treatment of acute musculoskeletal pain syndromes

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Low back pain (LBP) remains one of the most common causes of temporary disability and medical attention. Effective pharmacotherapy of acute pain requires a comprehensive approach that takes into account pathogenetic heterogeneity of this syndrome. This article considers the aspect concerning current potential of combination therapy for low back pain (LBP) using nonsteroidal anti-inflammatory drugs, glucocorticosteroids, and B vitamins, which can influence key components of the inflammatory and pain process. A possibility for using a combination drug containing betamethasone, hydroxocobalamin, and diclofenac, which has a predictable pharmacological profile, a favorable efficacy-to-safety ratio during short-term use, and ease of administration is introduced. The presence of diclofenac and hydroxocobalamin, an active form of vitamin B12 in its composition, defines the advantages of this combination, expanding its potential for use it in clinical practice. It is concluded that the use of modern combination drugs for rapid relief of acute LBP and prevention of chronic pain is rational.

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作者简介

Olga Mubarakshina

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia

编辑信件的主要联系方式.
Email: mubarakshina@mail.ru
ORCID iD: 0000-0001-6799-6322
SPIN 代码: 9008-1178

MD, PhD (Medicine), associate professor of the Department of clinical pharmacology

俄罗斯联邦, Voronezh

Yulia Dronova

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia

Email: y.dronova@yandex.ru
ORCID iD: 0000-0003-4513-091X
SPIN 代码: 7841-6498

MD, PhD (Medicine), associate professor of the Department of clinical pharmacology

俄罗斯联邦, Voronezh

Sergey Chernov

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia

Email: sergeych6868@mail.ru
ORCID iD: 0009-0002-8900-7745

MD, PhD (Medicine), associate professor of the Department of clinical pharmacology

俄罗斯联邦, Voronezh

Natalya Perova

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia

Email: natalyanp@yandex.ru
ORCID iD: 0000-0003-0529-1233

MD, assistant at the Department of clinical pharmacology

俄罗斯联邦, Voronezh

Daniil Stepkin

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia

Email: danya.stepkin.00@bk.ru
ORCID iD: 0000-0002-2187-7093

student

俄罗斯联邦, Voronezh

Maria Astanina

Voronezh City Clinical Polyclinic No. 3

Email: maas76@mail.ru
ORCID iD: 0009-0009-8585-6433

MD, PhD (Medicine), head

俄罗斯联邦, Voronezh

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