Influence of complex drug therapy on structural and functional properties of vessels and endothelial dysfunction in patients with arterial hypertension and ischemic heart disease
- Authors: Umetov M.A1, Khakuasheva I.A1,2, Akkaeva M.R1, Tamazova M.A1, Sanova A.Z1, Khakulova D.M1
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Affiliations:
- Kabardino-Balkarian State University named after H.M. Berbekov
- Cardiological Dispensary of the Ministry of Healthcare of Kabardino-Balkarian Republic
- Issue: Vol 7, No 8 (2021)
- Pages: 76-83
- Section: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/288558
- DOI: https://doi.org/10.18565/therapy.2021.8.76-83
- ID: 288558
Cite item
Open Access
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Abstract
Despite significant advances in the treatment of arterial hypertension (AH) and ischemic heart disease (IHD), mortality from these diseases remains high. Purpose: to compare the effect of bisoprolol and nebivolol in combination with a fixed combination (amlodipine + perindopril + indapamide) on the clinical course, functional state of arterial stiffness, endothelium, ankle-brachial index, vascular age in patients with AH of 2 and 3 degrees and IHD II and III functional classes. Material and methods. The study included 67 patients with uncontrolled AH with a systolic blood pressure (BP) level of И60 mmHg and/or diastolic blood pressure s90 mmHg in combination with stable exertional angina, who were taking two antihypertensive drugs at the start of the study. Depending on the therapy, the participants were divided into two groups: I - 34 people who received bisoprolol 5-10 mg/day; II - 33 people who took nebivolol at a dose of 5-10 mg/day. All patients also received a fixed combination of amlodipine + indapamide + perindopril. Results. The use of a fixed combination of amlodipine, indapamide and perindopril in combination with the beta-blocker nebivolol has a pronounced hypotensive effect on the level of peripheral and central arterial pressure, slows down the processes of vascular remodeling by improving the parameters of 77 arterial stiffness, vascular age, endothelial function indicator, which indicates an improvement in the state of elasticity - the elastic properties of the arterial wall and leads to a decrease in the risk of developing cardiovascular complications. Conclusion. The results obtained indicate that the addition of nebivolol to the fixed combination amlodipine + indapamide + perindopril leads to an effective decrease in heart rate, improved parameters of arterial stiffness and endothelial function, increased adherence and increased exercise tolerance.
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About the authors
M. A Umetov
Kabardino-Balkarian State University named after H.M. Berbekov
Email: umetovma0yandex.ru
360000, Nalchik, 5 Gorkogo Str. Tel.: +7 (909) 487-78-01
I. A Khakuasheva
Kabardino-Balkarian State University named after H.M. Berbekov; Cardiological Dispensary of the Ministry of Healthcare of Kabardino-Balkarian Republic
Email: inara23330yandex.ru
360000, Nalchik, 5 Gorkogo Str. Tel.: +7 (928) 708-73-77
M. R Akkaeva
Kabardino-Balkarian State University named after H.M. Berbekov
Email: magamalkarova0gmail.com
360000, Nalchik, 5 Gorkogo Str. Tel.: +7 (928) 711-22-23
M. A Tamazova
Kabardino-Balkarian State University named after H.M. Berbekov
Email: tbb4040mail.ru
360000, Nalchik, 5 Gorkogo Str. Tel.: +7 (964) 038-65-99
A. Z Sanova
Kabardino-Balkarian State University named after H.M. Berbekov
Email: amina07.000mail.ru
360000, Nalchik, 5 Gorkogo Str. Tel.: +7 (906) 251-46-41
D. M Khakulova
Kabardino-Balkarian State University named after H.M. Berbekov
Email: khakulova100gmail.com
360000, Nalchik, 5 Gorkogo Str. Tel.: +7 (928) 702-82-86
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