Clinical case: autoimmune hepatitis and primary sclerosing cholangitis overlap syndrome


Дәйексөз келтіру

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Аннотация

In clinical practice, there are autoimmune overlap syndrome along with standard autoimmune liver diseases - autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC). Overlap syndrome means the presence in one patient of signs characteristic of two autoimmune diseases and, as a rule, is a combination: AIH/PBC, AIH/PSC. According to statistics, in a number of patients with AIH, the cross syndrome occurs with a frequency of no more than 10%. The article presents a case of diagnosis of overlap syndrome in a patient with a combination of AIH and PSC and ulcerative colitis.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Amina Alieva

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: amisha_alieva@mail.ru
PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine

Ilda Almazova

National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of Russia

Email: almazovai@rambler.ru
PhD, doctor-teacher of the Methodological Accreditation and Simulation Center

Lyudmila Brutskaya

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia; Treatment and Rehabilitation Center of the Ministry of Healthcare of Russia

Email: ludmila3to@mail.ru
head of the Department of therapy

Irina Baykova

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: 1498553@mail.ru
PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine

Roza Arakelyan

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: sharm@yandex.ru
student of the Faculty of medicine

Anna Salnikova

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: salnickova5@mail.ru
student of the Faculty of medicine

Olga Ettinger

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: olga-oett@mail.ru
PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine

Vladimir Kislyakov

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: kvadoctor@mail.ru
PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine

Anna Modestova

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: a.modestowa@yandex.ru
PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine

Tatiana Pinchuk

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: doktor2000@inbox.ru
PhD, associate professor of the Department of faculty therapy of the Faculty of pediatrics

Anna Tikhomirova

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: strelka_90@inbox.ru
PhD, assistant of the Department of hospital therapy No. 2 of the Faculty of medicine

Gayane Toтolyan

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: tgg03@mail.ru
PhD, associate professor of the Department of hospital therapy No. 2 of the Faculty of medicine

Madina Kudaeva

Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labour and Social Protection of Russia

Email: lyalyusha1974@mail.ru
physician for medical and social examination, therapist of the expert staff of Main Bureau of Medical and Social Expertise

Dzhannet Elmurzaeva

H.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia

Email: jannet.elmurzaeva@yandex.ru
associate professor of the Department of microbiology, virology and immunology

Raziyat Kadyrova

H.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia

Email: kadirova47@yandex.ru
lecturer of the highest category of Medical College

Alik Rakhaev

Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labour and Social Protection of Russia; H.M. Berbekov Kabardino-Balkarian State University of the Ministry of Science and Higher Education of Russia

Email: alikrahaev@yandex.ru
MD, head of the expert staff of Main Bureau of Medical and Social Expertise

Ramiz Valiev

A.S. Loginov Moscow Clinical Scientific Center of the Department of Healthcare of Moscow

Email: radiosurgery@bk.ru
PhD, head of the Department of surgical oncology No.2

Igor Nikitin

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia; Treatment and Rehabilitation Center of the Ministry of Healthcare of Russia

Email: igor.nikitin.64@mail.ru
MD, professor, head of the Department of hospital therapy No. 2 of the Faculty of medicine

Әдебиет тізімі

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  2. Sahebjam F., Vierling J.M. Autoimmune hepatitis. Front Med. 2015; 9(2): 187-219. doi: 10.1007/s11684-015-0386-y.
  3. Aabakken L., Karlsen T.H., Albert J. et al. Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline. Endoscopy. 2017; 49(6): 588-608. doi: 10.1055/s-0043-107029.
  4. Floreani, A. Clinical course and outcome of autoimmune hepatitis/ primary sclerosing cholangitis overlap syndrome / A. Floreani et al. // Am. J. Gastroenterol. 2005. Vol. 100. P. 1516-1522.
  5. Ивашкин В.Т., Широкова Е.Н., Маевская М.В. с соавт. Клинические рекомендации Российской гастроэнтерологической ассоциации и Российского общества по изучению печени по диагностике и лечению холестаза. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2015; 2: 41-57.
  6. Подымова С.Д. Перекрестные аутоиммунные синдромы в гепатологии. Экспериментальная и клиническая гастроэнтерология. 2013; 4: 3-12.
  7. Aguilar-Najera O., Velasco-Zamora J.A., Torre A. Overlap syndromes of autoimmune hepatitis: diagnosis and treatment. Rev Gastroenterol Mex. 2015; 80(2):150-59. doi: 10.1016/j.rgmx.2015.04.001.
  8. Подзолков В.И., Драгомирецкая Н.А., Волчкова Е.В., Митрохина О.И. Перекрестные синдромы при аутоиммунных заболеваниях печени. Клиническая медицина. 2017; 10: 940-945. doi: http://dx.doi.org/10.18821/0023-2149-2017-95-10-940-945.
  9. Rossi R.E., Conte D., Massironi S. Primary sclerosing cholangitis associated with inflammatory bowel disease: an update. Eur J. Gastroenterol Hepatol. 2016; 28(2): 123-31. doi: 10.1097/meg.0000000000000532.

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