Prognostic usefulness of changes in hemostatic parameters of dogs with parvoviral enteritis

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Abstract

The aim of the work was to study the prognostic usefulness of changes  in hemostatic parameters of dogs with parvoviral enteritis.Compared the results of a study of the blood of the dead (n = 4) and the surviving dogs (n = 11) on days 3 and 5 of illness between 2 and 6 months of age among themselves and with the results of blood tests of healthy dogs in the control group (n = 10).On the 3rd day of the disease, we can identify as markers of an unfavorable prognosis a decrease in platelet count to 285,97±14,84х109/L, an increase inMPV to 8,5±1,7 fl and PCT to 0,53±0,02%, an increase in SIAP with ADP to 131,67±9,28% and ristomycin to 127,77±14,71%, a decrease in disaggregation with ADP to1,03±1,03% and ristomycin to 0,08±0,08%, an increase in the amount of fibrinogen to 5,2±0,49 g/l  and SFMC to 12,97±1,15 mg/100ml along with a decrease in the activity of antithrombin to 105,3±3,16%.On the 5th day of illness, such parameters as a progressive decrease in platelet count to227±15,64 х109/L  are associated with a decrease in the MPV to 5,5±1,2 fl  and PCT to 0,21±0,03%, a decrease in SIAP with ADP to 31,67±12,03%, collagen to 15,53±4,26%  and ristomycin to14,8±5,6%, reduction of disaggregation with all inductors, lengthening of PT from14,17±0,24  to18,5±2,9 sec., TT from9,07±0,58  to 26,37±1,57 sec. and APTT from18,03±1,54 to 26,37±1,57 sec., increase in SFMC to17,3±1,17mg/100ml, a decrease in fibrinogen to 2,73±0,89g/l  and antithrombin activity to 88,63±14,93%.

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About the authors

E. S. Baruzdina

Vologda State Dairy Farming Academy named after N.V. Vereshchagin

Author for correspondence.
Email: ENSobol@yandex.ru
Russian Federation, Vologda

E. N. Soboleva

Vologda State Dairy Farming Academy named after N.V. Vereshchagin

Email: ENSobol@yandex.ru

кандидат ветеринарных наук

Russian Federation, Vologda

References

  1. Власов Н.А., Уласов В.И., Черняева И.С., Элизбарашвили Э.И., Вахрамеева В.В., Васильев Д.А. Парвовирусы плотоядных и вызываемые ими болезни. – Ульяновск, 2000. – 35 с.
  2. Houston D.M., Ribble C.S., Head L.L. Risk factors associated with parvovirus enteritis in dogs: 283 cases (1982-1991) // J. Am. Vet. Med. Assoc. – 1996. – 208(4). – Р.542-546.
  3. Сулимов А.А., Уласов В.И. Парвовирусные инфекции плотоядных // Российский Ветеринарный Журнал. Мелкие Домашние Животные – 2008. – №2. – С.40- 45.
  4. Mathios E., Mylonakis, Iris Kalli, Timoleon S. Rallis Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention // Veterinary Medicine: Research and Reports. – 2016. – P.91-100.
  5. Goddard A., Leisewitz A.L Canine parvovirus // Vet. Clin. North Am. Small Anim. Pract. – 2010. – №40(6). – Р.1041-1053.
  6. Gauthier V. Effects of Tetrastarch Administration on Hemostatic, Laboratory, and Hemodynamic Variables in Healthy Dogs and Dogs with Systemic Inflammation // A Thesis presented to The University of Guelph. - Guelph, Ontario, Canada. – 2013. - 164 рр.
  7. Баруздина Е.С. Возрастные особенности плазменно-коагуляционного гемостаза у собак, больных парвовирусной инфекцией// Актуальные вопросы ветеринарной биологии. – 2018. – №2 (38). – С.4-10.
  8. Otto C.М., Riеsеr Т.M., Brooks М.B. Еvidеnсе of hipеrсoagulability in dogs with рaгvоviral еntеritis // J. Am. Vеt. Mеd. Assoс. – 2000. – №21(7). – Р. 1500-1504.
  9. Kocaturk M.S., Martinez O., Eralp A., Tvarijonaviciute J., Ceron Z., Yilmaz Prognostic value of serum acute phase proteins in dogs with parvoviral enteritis // J. Small Anim. Pract. – 2010. – №51(9). – Р.478-483.
  10. Goddard A., Leisewitz A.L., Christopher M.M., Duncan N.M., Becker P.J. Prognostic Usefulness of Blood Leukocyte Changes in Canine Parvoviral Enteritis // Journal of Veterinary Internal Medicine. – 2008. – №22(2). – Р.309–316.
  11. Schoeman J.P., Goddard A., Leisewitz A.L. Biomarkers in canine parvovirus enteritis // N.Z. Vet. J. – 2013. – №61(4). – Р.217-222.
  12. Баруздина Е.С., Ошуркова Ю.Л. Особенности функционирования системы гемостаза у здоровых собак в возрасте от двух до шести месяцев // Актуальные вопросы ветеринарной биологии. – 2016. – №3(31). – С.8-12.
  13. Балуда В. П., Баркаган З. С., Гольдберг Е.Д.. Лабораторные методы исследования системы гемостаза. – Томск, 1980. – 304 с.
  14. Девяткин А. В. Клиническое значение нарушений микроциркуляции и гемореологии при гриппе и других острых респираторных вирусных инфекциях у больных с осложнениями и сопутствующими заболеваниями. – Дисс. … д. мед. наук: 14.00.10. М., 2003. – 272 с.

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2. Fig. 1. Morphological parameters of platelets in dead and surviving dogs: a) - average platelet volume, fl, b) - platelet count,%.

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3. Fig. 2. Vascular-platelet hemostasis in dead and surviving dogs (control group indicators are taken as 100%): a) on the 3rd day of illness, b) on the 5th day of illness.

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4. Fig. 3. Plasma-coagulation hemostasis in dead and surviving dogs (indicators of the control group are taken as 100%): a) on the 3rd day of illness, b) on the 5th day of illness.

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