Healing of induced previous damage to skin under the influence of autological cells stromal-vascular fraction

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In the experiment on Guinea pigs, the course of reparative skin regeneration after application of a flap wound under the influence of cellular suspensions from autologous stromal vascular fraction was studied. The material was investigated by clinical observation, light - optical studies of biopsy material, macro-and microscopic morphometry. Cell material was obtained by liposuction from the withers of the animal. Autologous adipose tissue was used to prepare a cell suspension containing a set of cells (fibroblasts, pericytes, acrophages, fat cells, endothelial cells) that make up the stromal-vascular fraction. The findings suggest that the use of cellular product leads to faster (compared with the control) healing of the defect, the formation of regenerate, morphologically similar to the surrounding intact skin. In the structure of the regenerate microscopically found restoration of the structural zones of the skin: the epidermis, dermis and subcutaneous fat. In the Central part of the regenerate, a small portion of the scar structure was preserved, the area of which is significantly less than that of the control analogues. Thus, the use of cellular products enhances the processes of reparative regeneration and is an effective way of therapeutic effects in the treatment of skin wounds.

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Sobre autores

N. Slesarenko

Moscow State Academy of Veterinary Medicine and Biotechnology – MBA named after K.I. Skryabin

Email: borhunova@mail.ru

doctor of biological sciences

Rússia, Moskva, ul. Academika Scriabina, 23

E. Borhunova

Moscow State Academy of Veterinary Medicine and Biotechnology – MBA named after K.I. Skryabin

Autor responsável pela correspondência
Email: borhunova@mail.ru

doctor of biological sciences

Rússia, Moskva, ul. Academika Scriabina, 23

N. Vologjanina

Moscow State Academy of Veterinary Medicine and Biotechnology – MBA named after K.I. Skryabin

Email: borhunova@mail.ru

candidate of biological sciences

Rússia, Moskva, ul. Academika Scriabina, 23

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