Assessment of a new device for local application of microwaves to destroy colorectal metastases in the liver


We have designed a new instrument for termoablation of colorectal metastases in the liver based on the use of high frequency energy. In order to assess the efficieny of the device, experiments on large laboratory animals were performed and the affected zone was investigated using light and electron microscopy. In the clinical practice, analyses of compound effects of microwaves on the liver metastasis in 19 colorectal cancer patients demonstrated the effectiveness of our method. Microscopic and ultrastructural investigation of the removed tissue revealed particular features of destruction of liver metastases resulting from local application of microwave energy. 10 patients with bilateral liver metastases underwent two-step surgical treatment with the use of the microwave method. Assessment of the performance of the microwave method during the second step of the operation showed that in 9 cases of 10 the metastases in the liver were destroyed.

V E Zagainov

Volga region medical center of the Russian Health Ministry, Nizhnii Novgorod


  1. Давыдов М.И., Аксель Е.М. Заболеваемость злокачественными новообразованиями населения России и стран СНГ в 2006 г. // Вестник РОНЦ им. Н.Н. Блохина РАМН. 2008. Т. 19. № 2 (Прил. 1). С. 53.
  2. Долгушин Б.И., Патютко Ю.И. и др. Радиочастотная термоаблация опухолей печени / Под ред. М.И. Давыдова. М.: Практическая медицина, 2007. 187 с.
  3. Коваленко Ю.А., Чжао А.В., Чугунов А.О. Выбор объема оперативного вмешательства при очаговых заболеваниях печени // 2009. Т. 14. С. 79-87.
  4. Adam R., Laurent A., Azoulay D. et al. Two-stage hepatectomy: A planned strategiy to treat irresect- able liver tumors // Ann. Surg. 2000. Vol. 232. P. 777-785.
  5. Abdalla E.K., Vautey J.N., Ellis L.M. et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ab- lation for colorectal metastases // Ann. Surg. 2004. Vol. 239. №6. P. 818-825.
  6. Arru M., Aldrighetti L., Castoldi R. et al. Analysis of prognostic influencig longterm survival after hepatic resection for metastatic colorectal cancer // World J. Surg. 2008. Vol. 32. P. 93-103.
  7. Bokemeyer C., Bondarenko I., Hartmann J.T. et al. KRAS status and efficacy offirst-line treatment of patients with metastatic colorectal cancer (rnCRC) with FOLFOX with or without cetuximab: The OPUS experience // J. Clin. Oncol. 2008. Vol. 26 (Suppl.): abstr 4000.
  8. Bouganim N., Kavan P., Eid M. et al. Perioperative chemotherapy with bevacizumab (BV) for liver metastases (LM) in colorectal cancer (CRC): McGill University pilot study // J. Clin. Oncol. 2009. Vol. 27 (Suppl.): abstr 5027.
  9. Curley S., Marra R, Beaty K. et al. Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients // Ann. Surg. 2004. Vol. 239. P. 450-458.
  10. Fernandez F.G., Drebin J.A., Linehan D.C. etal. Fio- fe-year survival after resection of hepatic metastases from colorectal cancer in patients screened by position emission tomography with F-18 fluorodeox- yglucose (FDG-PET) // Ann. Surg. 2004. Vol. 240. P. 438-447; discussion 447^150.
  11. Gomez D., Morris-Stiff G., Wyatt J. et al. Surgical technique and systemic inflammation influences longterm diseasefree survival following hepatic resection for colorectal metastasis // J. Surg. Oncol. 2008. Vol. 98. P.371-376.
  12. Hirano Y., Omura K., Tatsuzawa Y. et al. Tissue oxygen saturation during colorectal surgery measured by nearinfrared spectroscopy: pilot study to predict anastomotic complications // World J. Surg. 2006. Vol. 30 (3). P.457-461.
  13. Jaeck D., Oussoulzoglou E., Rosso E. et al. A two- stage hepatectomy procedure combinet with portal vein embolization to achieve curative resection for initiale unresectable nultiple and bilobar colorectal liver metastasers // Ann. Surg. 2004. Vol. 240. P. 1037-1049; discussion 49-51.
  14. Kusaka K., Imamura H., Tomiya T. et al. Expression of transformating growth factor-alpha and-beta in hepatic lobes after hemihepatic portal vein embolization //Dig. Dis. Dei. 2006. Vol. 8. P. 1404-1412.
  15. Kuromatsu R., Tanaka M., Shimauchi Y. et al. Light and electron microscopic analyses of immediate and late tissue damage caused by radiofrequency ablation in porcine liver // Int. J. Mol. Med. 2003. №11. P. 199-204.
  16. Paschos K.A., Bird N. Current diagnostic and therapeutic approaches for colorectal cancer liver metastasis // Hippocratia. 2008. Vol. 12. № 3. P. 132-138.
  17. Pawlik T.M., Schulick R.D., Choti M.A. Expanding criteria for respectability of colorectal liver metasta- sts // Oncologist. 2008. Vol. 13. P. 51-64.
  18. Saltz L., Clarke S., Diaz-Rubio E. et al. Bevacizum- ab (Bev) in combination with XELOX or FOLF- OX4: Updated efficacy results from XELOX-1/ N016966, a randomized phase III trial in first-line metastatic colorectal cancer // J. Clin. Oncol. 2007. ASCO Annual Meeting Proceedings. Part I. 2007. Vol. 25 (18S; Suppl.). P.4028.
  19. Tanaka K., Shimada FI., Matsumoto C. et al. Impact of the Degree of Liver Resection on Survival for Patients with Multiple Liver Metastases from Colorectal Cancer // World J. Surg. 2008. Vol. 32. P. 2057- 2069.
  20. Togo S., Nagano N., Mascui H. et al. Two-stage hepatectomy for multiple bilobar liver metastases from colorectal cancer // Hepato-gastroenterology. 2005. Vol. 52. P.913-919.
  21. Tominson J.S., Jarnagin W.R., DeMatteo R.P. et al. Actual 10-year survival after resection of colorectal liver metastases defines cure // J. Clin. Oncol. 2007. Vol. 25. P. 4575-4580.
  22. Wai Lun Law., Hok Kwok Choi., Yee Man Lee. et al. Anastomotic leakage is associated with poor longterm outcome in patients after curative colorectal resection for malignancy // J. Gsatroinestinal. Surg. 2007. Vol. 11 (1). P.8-15.


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