Variability in blood and risk of mortality of cancer patients



Cite item

Full Text

Abstract

A comparison of periodic changes of circulating MNC subsets number and current rate of death for 69 cancer patients during last months of their life was performed with flow cytometry and mathematical approximation of kinetic curves by periodic and aperiodic functions. It is shown, that rate of death values oscillate along with life span reduction, being synchronized contrariwise (oppositely) with pulses of periodic recruitment of CD34+ progenitor cells and some other subsets into circulation. The more extensive the signs of periodicity are presented in comparing groups of patients the shorter the rest of their life span and less survival at referent time point. No matter for this rule, if the comparing groups belong to different nosology or pick out of one nosology

Full Text

Restricted Access

About the authors

A Nikolaevich Shoutko

Russian Research Center of Radiology and Surgery Technologies. St. Petersburg

Email: shoutko@inbox.ru

L P Ekimova

Russian Research Center of Radiology and Surgery Technologies. St. Petersburg

V P Sokurenko

Russian Research Center of Radiology and Surgery Technologies. St. Petersburg

V F Mus

Russian Research Center of Radiology and Surgery Technologies. St. Petersburg

K S Matyurin

Russian Research Center of Radiology and Surgery Technologies. St. Petersburg

A M Granov

Russian Research Center of Radiology and Surgery Technologies. St. Petersburg

References

  1. Бочкарева Т.Н., Немкова Е.В., Сокуренко В.П. и др. Скрытая прогностическая неоднородность онкологических больных // Вопр. онкол. 2008. Т. 54. № 4. С. 480-482.
  2. Гранов А.М., Шутко А.Н. Парадоксы злокачественного роста и тканевой несовместимости. СПб.: Гиппократ, 2002.
  3. Карамуллин М.А., Сосюкин A.E., Шутко А.Н. и др. Роль возрастных изменений лимфопоэза в динамике заболеваемости ликвидаторов последствий чернобыльской аварии в отдаленный период // Мед. радиол, и радиац. безопасность. 2006. Т. 54. № 4. С. 42-51.
  4. Панченко К.И., Шубин Л.Б., Надеждин A.C. и др. Связь между митотическим режимом эпителия и лимфоцитами внутри его на этапах развития аденокарцином // Рос. иммунол. журн. 2008. Т. 2. № 2-3. С. 318.
  5. Рябов С.И., Ракитянская И.А., Шутко А.Н. Почка и система иммунитета. Л.: Наука, 1989.
  6. Количественные оценки эффективности лечения рака молочной железы / Р.В. Ставицкий, Г.А. Паншин (ред.). М., 2007.
  7. Шутко A.H., Акушевич И., Екимова Л.П. и др. Вариабельность риска смертности онкологических больных. К проблеме индивидуализированной терапии // Вопр. онкол. 2010. Т. 56. № 4. С. 430-434.
  8. Baltschukat K., Nothdurft W. Hematological effects of unilalateral and bilateral exposures of dogs to 300-kVp X rays // Radiat. Res. 1990. Vol. 123. № 1. P. 7-16.
  9. Bauer H.H. The origins, persistence and failings of HIV/AIDS theory // Me Farland Publishing. USA. 2007. P. 277-284.
  10. Dehos A. Haematological and immunological indicators for radiation exposure // Kerntechnik. 1990. Vol. 55. №4. P. 211-218.
  11. Droge W., Gross A., Hack V. et al. Role of cystein and glutation in HIV, infection and cancer cachexia // Advances in Pharmacol. 1997. Vol. 38. P. 501-508.
  12. Fliedner T.M., Graessle D.H. Hematopoietic cell renewal system: mechanisms of coping and failing after chronic exposure to ionizing radiation // Rad. and Envir. Bioph. 2008. Vol. 47. № 1. P. 63-69.
  13. Folkman Ju. A novel anti-vascular therapy of cancer // Cancer Biology and Therapy. 2004. Vol. 3. № 3. P. 338-339.
  14. Glass L. Synchronization and rhythmic processes in physiology // Nature. 2001. Vol. 410. № 6825. P. 277-284.
  15. Haurie C., Person R., Dale D.C., Mackey M.C. Hematopoietic dynamics in grey collies // Exp. Hematol. 1999. Vol. 27. № 7. P. 1139-1148.
  16. Ho A.D., Wagner W., Mahlknecht U. Stem cells and ageing // Eur. Mol. Biol. Organiz. Rep. 2005. Vol. 6 (Suppl.). P. 35-38.
  17. Jin Hur, Han-Mo Yang, Chang-Hwan Yoon et al. Identification of a novel role of T-cells in postnatal vasculogenesis // Circulation. 2007. Vol. 116. № 15. P. 1671- 1682.
  18. Naumov G.N., Akslen L.A., Folkman Ju. Role of angiogenesis in human tumor dormancy // Cell Cycle. 2006. Vol. 5. № 16. P. 1779-1787.
  19. Nothdurft W. Bone Morrow // Medical Radiology Radiopathology of Organs and Tissues / Eds. W.E. Scherer, Ch. Streffer, K.-R. Trott. Berlin: Heidelberg, Springer Ferlag, 1991. P. 113-169.
  20. Reihelt H., Barz D., Thude H. CD34+and CD 133+ primitive stem cells in peripheral blood: considering gender, age, and smoking // Transfuse. Med. Hemother. 2009. Vol. 36. № 2. P. 129-134.
  21. Shoutko A., Karamullin M., Ekimova L. et al. Latent time of generation of different lymphocytes subsets in blood of Chemobyls clean up workers // 34th Annual Meeting of the European Society for Radiation Biology: Abstracts. University of Leicester, UK. 5-8.09.2005. P. 166-167.
  22. Shoutko A., Ekimova L., Shoumski I. et al. Lymphopoiesis of treated oncological patients is a probable source of individual life spans variability // 13th International Congress of Radiation Research. Abstract book. San Francisko, USA. 8-12.07.2007. P. 58.
  23. Shoutko A., Akushevich I., Ekimova L. et al. Terminal exhaustion of hematopoietic potentiality as universal cause of death //38th Annual Meeting of the European Radiation Research Society. Abstract book. Stockholm, Sweden. 5-9.09.2010. P. 187.
  24. Ziegelhoffer T., Fernandez B., Kostin S. et al. Bone morrow derived cells do not incorporate into adult growing vasculature // Circ. Res. 2004. Vol. 94. № 2. P. 230-238.
  25. Yamaura H., Matsuzava T. Tumor regrowth after inradiation // Int. J. Radiat. Biol. 1979. Vol. 35. № 3. P. 201-219.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Shoutko A.N., Ekimova L.P., Sokurenko V.P., Mus V.F., Matyurin K.S., Granov A.M.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies