Role of atypical bacteria and respiratory viruses in the development of community-acquired pneumonia in adult population of the Republic of Karelia
- Authors: Larina NA1, Pisareva MM2, Grudinin MP2, Kiselev OI2, Dudanova OP1
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Affiliations:
- Petrozavodsk State University
- Scientific Research Institute of Influenza, St. Petersburg
- Issue: Vol 11, No 3 (2011)
- Pages: 93-99
- Section: Articles
- Published: 15.09.2011
- URL: https://journals.eco-vector.com/MAJ/article/view/10026
- DOI: https://doi.org/10.17816/MAJ11393-99
- ID: 10026
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Abstract
We have examined 184 patients who had negative results in bacteriological analysis of sputum for typical bacteria. Nasopharyngeal swabs of 74 patients were tested with real-time PCR for genomes of influenza A and В viruses, parainfluenza virus, adenovirus, and respiratory-syncytial-virus. For 60 patients ELISA was carried out to detect the presence of IgM and IgG antibodies to mycoplasma and chlamidia pneumonia in pair sera, for 20 of them PCR analysis of sputum was also performed to detect genomes of mycoplasma pneumonia. In 50 patients with severe and moderate course of pneumonia, urine was tested by immunochromatography for legionella pneumophila antigen. Atypical bacterial flora was detected in 21,7% of patients, of those 11,7% had mycoplasma pneumonia, and 10,0% had chlamidia pneumonia. The clinical course of pneumonia was mild in all the patients, convalescence from pneumonia occurred within the usual period of time, and no complications were observed. The clinical picture was characterized by moderate intoxication and pulmonary consolidation syndrome, which was detected more frequently by radiological methods than by objective examination. Legionella pneumophila was not detected in the examined patients. Respiratory viruses were found in 12,2% of patients: 8,1% had adenovirus and 4,1% had influenza A virus (H3N2).The clinical picture was mild in all the patients. So, the contribution of atypical bacteria and respiratory viruses to the etiological structure of community-acquired pneumonia in adult population of the Republic of Karelia was insignificant, amounting to 21,7% and 12,2% accordingly. Pneumonia of these etiologies was characterized by a mild course.
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About the authors
N A Larina
Petrozavodsk State University
Email: lpu@onego.ru
M M Pisareva
Scientific Research Institute of Influenza, St. Petersburg
M P Grudinin
Scientific Research Institute of Influenza, St. Petersburg
O I Kiselev
Scientific Research Institute of Influenza, St. Petersburg
O P Dudanova
Petrozavodsk State University
References
- Киселев 0.И., Малый В.П., Зарубаев П.В. и др. Грипп H1N1 как типичная эмерджентная инфекция (вирусологические, клинико-эпидемиологические особенности, вопросы терапии и профилактики): пособие для врачей. СПб. - Харьков - Ужгород, 2009. 44 с.
- Ноников В.E., Воробьева М.Г. Диагностика и лечение микоплазменных пневмоний // Consilium medicum. 2005. T. 7. № 10. C. 39-43.
- Ноников В.E. Легочный хламидиоз: диагностика и лечение // Consilium medicum. 2007. T. 9. № 10. C. 46-52.
- Онищенко Г.Г., Покровский В.И., Тартаковский В.В. и др. Современные взгляды на эпидемию легионеллеза: алгоритм действий при эпидемических вспышках и профилактическом мониторинге // Журн. микробиол. 2008. № 2. С. 5-9.
- Сторожаков Т.И., Утешев Д.Б. Некоторые аспекты диагностики и лечения внебольничных пневмоний, вызванных атипичными возбудителями // Лечащий врач. 2005. № 8. С. 26-28.
- Трубников Г.В., Полякова И.Г., Бутакова Л.Ю. Внебольничная пневмония с атипичной (микоплазменной и хламидийной) инфекцией // Тер. арх. 2009. № 1.С. 16-20.
- Чучалин А.Г., Синопальников А.И., Страчунский Л.С. Пневмония. М.: Медицинское информационное агентство, 2006. 464 с.
- Чучалин А.Г. Исторические аспекты эпидемий гриппа XX века // Пульмонология. 2009. № 6. С. 5-8.
- Чучалин А.Г., Синопальников А.И., Козлов P.C. и др. Внебольничная пневмония у взрослых: практические рекомендации по диагностике, лечению и профилактике. М., 2010. 82 с.
- Щерба Ю.В., Гончарова И.В. Новые этиологические, эпидемиологические и клинические характеристики современной внебольничной пневмонии /. Поликлиника. 2005. № 2. С. 8-16.
- Falsey A.R., Walsh E.Е. Viral pneumonia in older adults // Clin. Infect. Dis. 2006. Vol. 42. № 4. P. 518-524.
- Gambarino S., Mantovani S., Astegiano S. et al. Lower respiratory tract viral infections in hospitalized adult patient // Minerva Med. 2009. Vol. 100. № 5. P. 349-355.
- Jenning L.C., Anderson T.P., Beynon K.A. et al. Incidence and characteristics of viral community-acquired pneumonia in adults // Thorax. 2008. Vol. 63. P. 42-48.
- Johnstone J., Majudar S.R., Fox J.D., Marrie T. S. Vial infection in adults hospitalized with community-acquired pneumonia. Prevalence, pathogens, and presentation // Chest. 2008. Vol. 134. P. 1141-1148.
- Lui G., Ip M., Lee N. et al. Role of ‘atypical pathogens’ among adult hospitalized patients with community-acquired pneumonia // Respirology. 2009. Vol. 14 (8). P. 1098-1107.
- Oosterheert J.J., van Loon A.M., Schuurman R. et al. Impact of rapid detection of viral and atipical bacterial patogens by realtime polymerase chain reaction for patient with lower respirator)' tract infection // Clin. Infect. Dis. 2005. Vol. 41. № 10. P. 1438-1444.
- Roux A., Marcos M.A., Garsia E. et al. Viral community-acquired pneumonia in nonimmunocompromised adults//Chest. 2004. Vol. 125. №4. P. 1343-1351.
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