Segmental anatomic brainstem structures involved in the development of headache

Abstract


The review provides information on anatomic and physiological characteristics of nervous structures involved in the development of headache. Particular attention is given to the trigeminal complex, structural and functional organization of its peripheral and central components. The connections between trigeminal nuclei and several brainstem structures in aspect of their involvement in the pathogenesis of cephalalgia are examined. The general properties of neurons of the trigemino-cervical complex and afferent fibers of the trigeminal nerve branches are characterized.

A Yu Sokolov

Email: leshasokolovl@arambler.ru

Yu D Ignatov

  1. Амелин А.В., Игнатов Ю.Д., Скоромец А.А. Мигрень - патогенез, клиника и лечение. СПб., 2001.
  2. Андреева Н.Г. Структурно-функциональная организация нервной системы. СПб., 2005.
  3. Волчков В.А., Игнатов Ю.Д., Страшнов В.И. Болевые синдромы в анестезиологии и реаниматологии. СПб., 2006.
  4. Гайворонский И.В. Нормальная анатомия человека. Т. 2. СПб., 2001.
  5. Лиманский Ю.П. Структура и функции системы тройничного нерва. Киев, 1976.
  6. Синельников Р.Д., Синельников Я.Р. Атлас анатомии человека. Т. 4. М., 1994.
  7. Соколов А.Ю., Амелин А.В., Игнатов Ю.Д., Пантелеев С.С. Влияние ГАМК-позитивных препаратов на фоновую и вызванную активность нейронов каудального ядра тройничного нерва крысы // Эксп. и клин, фармакол. 2008. Т. 71. № 5. С. 3-7.
  8. Afridi S.K., Shields K.G., Bhola R. et al. Greater occipital nerve injection in primary headache syndromes: prolonged effects from a single injection // Pain. 2006. Vol. 122. P. 126-129.
  9. Akerman S., Holland P.R., Goadsby P.J. Cannabinoid (CB1) Receptor Activation Inhibits Trigeminovascular Neurons // JPET. 2007.Vol. 320. P. 64-71.
  10. Akerman S., Holland P.R., Lasalandra M.P., Goadsby P.J. Oxygen inhibits neuronal activation in the trigeminocervical complex after stimulation of trigeminal autonomic reflex, but not diuing direct dural activation of trigeminal afferents // Headache. 2009. Vol. 49. P. 1131-1143.
  11. Aktekin B., Yaltkaya K., Ozkaynak S., Oguz Y. Recovery cycle of the blink reflex and exteroceptive suppression of temporalis muscle activity in migraine and tension-type headache // Headache. 2001. Vol. 41. № 2. P. 142-149.
  12. Albertyn J., Barry R., Odendaal C.L. Cluster headache and the sympathetic nerve // Headache. 2004. Vol. 44. P. 183-185.
  13. Ambrosini A., Vandenheede M., Rossi P. et al. Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study // Pain. 2005. Vol. 118. P. 92-96.
  14. AndreouA.P. Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology // Thesis submitted for the Degree of PhD at the faculty of Medicine, University College of London, 2008.
  15. Armstrong C.L., Hopkins D.A. Neurochemical organization of paratrigeminal nucleus projections to the. dorsal vagal complex in the rat // Brain Res. 1998. Vol. 785. № 1. P.49-57.
  16. Ashina M., Stallknecht B., Bendtsen L. et al. In vivo evidence of altered skeletal muscle blood flow in chronic tension-type headache // Brain. 2002. Vol. 125. P. 320-326.
  17. Ashina S., Jensen R., Bendtsen L. Pain sensitivity in pericranial and extracranial regions // Cephalalgia. 2003. Vol. 23. № 6. P. 456-462.
  18. Ashina S., Babenko L., Jensen R. et al. Increased muscular and cutaneous pain sensitivity in cephalic region in patients with chronic tension-type headache // Eur. J. Neurol. 2005. Vol. 12. № 7. P. 543-549.
  19. Bartsch T., Goadsby P.J. Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input // Brain. 2002. Vol. 125. P. 1496- 1509.
  20. Bartsch T., Goadsby P.J. The trigeminocervical complex and migraine: current concepts and synthesis // Curr. Pain Headache Rep. 2003a.Vol. 7. № 5. P. 371- 376.
  21. Bartsch T., Goadsby P.J. Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater // Brain. 2003b. Vol. 126. P. 1801-1813.
  22. Bartsch T., Goadsby P.J. Anatomy and physiology of pain referral in primary and ceivicogenic headache disorders // Headache Curr. 2005. Vol. 2. P. 42-48.
  23. Bartsch T. Migraine and the neck: new insights from basic data // Curr. Pain Headache Rep. 2005. Vol. 9. № 3. P. 191-196.
  24. Bauer D.F.,Youkilis A., Schenck C. et al. The falcine trigeminocardiac reflex: case report and review of the literature // Surg. Neurol. 2005.Vol. 63. № 2. P. 143- 148.
  25. BenaiTOch E.E. Pain-autonomic interactions // Neurol. Sci. 2006. Vol. 27. P. 130-133.
  26. BereiterD.A., Hirata H., Hu J.W. Trigeminal subnucleus caudalis: beyond homologies with the spinal dorsal horn//Pain. 2000. Vol. 88. P. 221-224.
  27. Bereiter D.A., Bereiter D.F., Ramos M. Vagotomy prevents morphine-induced reduction in Foslike immunoreactivity in trigeminal spinal nucleus produced after TMJ injury in a sex-dependent manner // Pain. 2002. Vol. 96. P. 205-213.
  28. Bergerot A., Reynier-Rebuffel A.M., Callebert J., Aubineau P. Long-tenn superior cervical sympathectomy induces mast cell hyperplasia and increases histamine and serotonin content in the rat dura mater // Neuroscience. 2000. Vol. 96. № 1. P. 205-213.
  29. Biondi D.M. Cervicogenic headache: mechanisms, evaluation, and treatment strategies // JAOA. 2000. Vol. 100. №9. P. 7-14.
  30. Biondi D.M. Cervicogenic Headache: A Review of Diagnostic and Treatment Strategies // JAOA. 2005. Vol. 105. №4. P. 16-22.
  31. Boes C.J., Dodiclc D.W. Refining the clinical spectrum of chronic paroxysmal hemicrania: a review of 74 patients // Headache. 2002. Vol. 42. № 8. P. 699-708.
  32. BogdukN. Cervicogenic headache: anatomic basis and pathophysiologic mechanisms // Curr. Pain Headache Report. 2001. Vol. 5. P. 382-386.
  33. Bohotin C., Scholsem M., Multon S. et al. Vagus nerve stimulation in awake rats reduces formalin-induced nociceptive behaviour and fos-immunoreactivity in trigeminal nucleus caudalis//Pain. 2003. Vol. 101. № 1. P. 3-12.
  34. Bolay H., Reuter U., Dunn A.K. et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model //Nat. Med. 2002. Vol. 8. P. 136-142.
  35. Bolton S., O’Shaughnessy C.T., Goadsby P.J. Properties of neurons in the trigeminal nucleus caudalis responding to noxious dural and facial stimulation // Brain Res. 2005. Vol. 1046. P. 122-129.
  36. Branch M.A. Headache Disability in Orofacial Pain Patients Is Related to Traumatic Life Events // Headache. 2009. Vol. 49. № 4. P. 535-540.
  37. Burstein R., Yamamura H., Malick A. et al. Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons // J. Neurophysiol. 1998. Vol. 79. P. 964- 982.
  38. Burstein R., Jalmbowski М. Unitary hypothesis for multiple triggers of the pain and strain of migraine // J. Comp. Neurol. 2005. Vol. 493. № 1. P. 9-14.
  39. Busch V., Frese A., Bartsch T. The trigemino-cervical complex. Integration of peripheral and central pain mechanisms in primary headache syndromes // Schmerz. 2004. Vol. 18. P. 404-410.
  40. Busch V, Jakob W., Juergens T. et al. Functional connectivity between trigeminal and occipital nerves revealed by occipital nerve blockade and nociceptive blink reflexes // Cephalalgia. 2006. Vol. 26. № 1. P. 50-55.
  41. Busch V, Jakob W., Juergens T. et al. Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves // Cephalalgia. 2007. Vol. 27. P. 1206-1214.
  42. Calandre E.P., Hidalgo J., Garcia-Leiva J.M., Rico-Villademoros F. Trigger points evaluation in migraine patients: An indication of peripheral sensitization linked to migraine predisposition? // Eur. J. Neurol. 2006. Vol. 13. P. 244-249.
  43. Calandre E.P., Hidalgo J., Garcia-Leiva J.M. et al. Myofascial trigger points in cluster headache patients: a case series // Head & Face Med. 2008. Vol. 4. P. 32.
  44. Caous C.A., Buck H.S., Lindsey C.J. Neuronal connections of the paratrigeminal nucleus: a topographic analysis of neurons projecting to bulber, pontine and thalamic nuclei related to cardiovascular, respiratory and sensory functions // Auton. Neurosci. Basic Clin. 2001. Vol. 94. P 14-24.
  45. Carius A., Schulze-Bonhage A. Trigeminal pain under vagus nerve stimulation // Pain. 2005. Vol. 118. № 1- 2. P 271-273.
  46. Chandler M.J., Qin C., Yuan Y., Foreman R.D. Convergence of trigeminal input with visceral and phrenic inputs on primate C1-C2 spinothalamic tract neurons // Brain Res. 1999. Vol. 829. P. 204-208.
  47. Coste J., Voisin D.L., Luccarini P, Dallel R. A role for wind-up in trigeminal sensory processing: intensity coding of nociceptive stimuli in the rat // Cephalalgia. 2008. Vol. 28. P.631-639.
  48. Dallel R., Duale C., Molat J.L. Moiphine administered in the substantia gelatinosa of the spinal trigeminal nucleus caudalis inhibits nociceptive activities in the spinal trigeminal nucleus oralis // J. Neurosci. 1998. Vol. 18. P. 3529-3536.
  49. Dauvergne C., Pinganaud G., Buisseret P. et al. Reticular premotor neurons projecting to both facial and hypoglossal nuclei receive trigeminal aferents in rats // Neurosci. Lett. 2001. Vol. 311. P. 109-112.
  50. Dauvergne C., Zerari-Mailly F., Buisseret P. et al. The sensory trigeminal complex projects contralaterally to the facial motor and the accessory abducens nuclei in the rat // Neurosci. Lett. 2002. Vol. 329. P 169-172.
  51. De Marinis M., Pujia A., Colaizzo E., Accornero N. The blink reflex in «chronic migraine» // Clin. Neurophysiol. 2007. Vol. 118. № 2. P. 457-463.
  52. De Sousa B.H., Caous C.A., Lindsey C.J. Projections of the paratrigeminal nucleus to the ambiguus, rostro- ventrolateral and lateral reticular nuclei, and the solitary tract // Auton. Neurosci. 2001. Vol. 87. № 2-3. P 187-200.
  53. Di Stani F., Calabresi M., Pappagallo M. et al. Atypical primary headache responding to finger pressure: possible involvement of the vagus nerve? // J. Headache Pain. 2007. Vol. 8. P. 60-62.
  54. Ebersberger A. Physiology of meningeal innervation: aspects and consequences of chemosensitivity of meningeal nociceptors // Microsc. Res. Tech. 2001. Vol. 53. №2. P. 138-146.
  55. Edvinsson L., Uddman R. Neurobiology in primary headaches // Brain Res. 2005. Vol. 48. № 3. P. 438- 456.
  56. Furata T., Timofeeva E., Nakamura K. et al. Inhibitory Gating of Vibrissal Inputs in the Brainstem // J. Neurosci. 2008. Vol. 28. № 8. P. 1789-1797.
  57. Garcia-Leiva J.M., Hidalgo J., Rico-Villademoros F. et al. Effectiveness of ropivacaine trigger points inactivation in the prophylactic management of patients with severe migraine // Pain Med. 2007. Vol. 8. P. 65-70.
  58. Goadsby P.J., Chabrit A.R., Andreou A.P, Akerman S. Neurobiology of migraine //Neuroscience. 2009. Vol. 161. P.327-341.
  59. Goadsby P.J., Cohen A.S. Pathophysiology and treatment of h'igeminal autonomic cephalalgias // Schmertz. 2008. Vol. 22. № 1. P.7-10.
  60. Goadsby P.J., Bartsch T., Dodick D. W. Occipital nerve stimulation for headache: mechanisms and efficacy // Headache. 2008. Vol. 48. № 2. P. 313-318.
  61. Goadsby P.J., Matharu M.S., Boes C.J. SUNCT syndrome or trigeminal neuralgia with lacrimation // Cephalalgia. 2001. Vol. 21. P.82-83.
  62. Goadsby PJ. Migraine, allodinia, sensitisation and all of that.. // Eur. Neurol. 2005. Vol. 53 (Suppl. 1). P. 10-16.
  63. Gottselig R., Messlinger K. Noxious chemical stimulation of rat facial mucosa increases intracranial blood flow through a trigemino-parasympathetic reflex: an experimental model for vascular dysfunctions in cluster headache // Cephalalgia. 2004. Vol. 24. № 3. P. 206-214.
  64. Gupta R., Bhatia M.S. A report of cranial autonomic symptoms in migraineurs // Cephalalgia. 2007. Vol. 27. № 1. P. 22-28.
  65. Guy N., Chalus M., Dallel R., Voisin D.L. Both oral and caudal parts of the spinal trige-minal nucleus project to the somatosensory thalamus in the rat //Eur. J. Neurosci. 2005. Vol. 21. № 3. P. 741-754.
  66. Holle D., Obermann M., Katsarava Z. The electrophysiology of cluster headache // Сшт. Pain Headache Rep. 2009. Vol. 13. № 2. P. 155-159.
  67. Hoslcin K.L., Goadsby P.J. Exposure and isolation of the superior sagittal sinus elicits Fos in the trigeminal nucleus caudalis and dorsal horn of the cervical spinal cord: how long should you wait? // Brain Res. 1999. Vol. 824. P. 133-135.
  68. Hoskin K.L., Bulmer D.C., Goadsby P.J. Fos expression in the trigeminocervical complex of the cat after stimulation of the superior sagittal sinus is reduced by L-NAME // Neurosci. Lett. 1999a. Vol. 266. № 3. P. 173-176.
  69. Hoskin K.L., Zaganri A.S., Goadsby PJ. Stimulation of the middle meningeal artery leads to Fos expression in the trigeminocervical nucleus: a comparative study of monkey and cat // J. Anat. 1999b. Vol. 194. Pt. 4. P. 579-588.
  70. Hoskin K.L., Lambert G.A., Donaldson C., Zaganri A.S. The 5 hydroxytryptamine 1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovas- cular input to the nucleus tractus solitarius in the cat // Brain Res. 2004. Vol. 998. P. 91-99.
  71. Imbe IT., Dubner R., Ren K. Masseteric inflammation- induced Fos protein expression in the trigeminal interpolaris/caudalis transition zone: contribution of somatosensory-vagal-adrenal integration // Brain Res. 1999. Vol. 845. № 2. P. 165-175.
  72. Jakubowski M., Levy D., Goor-Aryeh I. et al. Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors // Headache. 2005. Vol. 45. P. 850-861.
  73. Jakubowski M., Levy D., Kainz V. et al. Sensitization of central trigenrinovascular neurons: blockade by intravenous naproxen infusion // Neuroscience. 2007. Vol. 148. №2. P. 573-583.
  74. Jarrar R.G., Black D.F., Dodick D.W., Davis D.H. Outcome of trigeminal nerve section in the treatment of chronic cluster headache // Neurology. 2003. Vol. 60. P. 1360-1362.
  75. Knight Y.E., Classey J.D., Lasalandra M.P. et al. Patterns of fos expression in the rostral medulla and caudal pons evoked by noxious craniovascular stimulation and periaqueductal gray stimulation in the cat // Brain Res. 2005. Vol. 1045. P. 1-11.
  76. Lambert G.A., Hoskin K.L., Zaganri A.S. Nitrergic and glutamatergic neuronal mechanisms at the trigenr- inovascular first-order synapse // Neuropharm. 2004. Vol. 47. P.92-105.
  77. Lazarov N.E. Neurobiology of orofacial proprioception // Br. Res. Rev. 2007. Vol. 56. P. 362-383.
  78. Le Doare K., Akerman S., Holland P.R. et al. Occipital afferent activation of second order neurons in the trigeminocervical complex in rat//Neurosci. Lett. 2006. Vol. 403. P. 73-77.
  79. Lenaerts M.E., Oomnien K.J., Couch J.R., Skaggs V. Can vagus nerve stimulation help migraine? // Cephalalgia. 2008. Vol. 28. P. 392-395.
  80. Leone M., Franzini A., Cecchini A. et al. Stimulation of occipital nerve for drug-resistant chronic cluster headache // Lancet Neurol. 2007. Vol. 6. № 4. P. 289-291.
  81. Leroux E., Ducros A. Cluster headache // Orph. J. Rare Dis. 2008.ѴОІ. 3. P. 20-31.
  82. Levy D., Burstein R., Kainz V. et al. Mast cell degranulation activates a pain pathway underlying migraine headache // Pain. 2007. Vol. 130. P. 166-176.
  83. Levy D., Zhang X., Jakubowski M., Burstein R. Sensitization of meningeal nociceptors: inhibition by Naproxen // Eur. J. Neurosci. 2008. Vol. 27. P. 917-922.
  84. Lu Y., Perl E.R. A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input// J. Neurosci. 2003. Vol. 23. P. 8752-8758.
  85. Ma W., Zhang W., Xiong K., Guo F. Visceral and orofacial somatic afferent fiber terminals converge onto the same neuron in paratrigeminal nucleus: An electron microscopic study in rats //Auton. Neurosci. 2007. Vol. 131. № 1-2. P. 45^19.
  86. Magis D., Aliena M., Bolla M. et al. Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study // Lancet Neurol. 2007. Vol. 6. P. 314-321.
  87. Malick A., Burstein R. Cells of origin of the trigeminohypothalanric tract in the rat // J. Comp. Neurol. 1998. Vol. 400. № l.P. 125-144.
  88. Malick A., Strassman A., Burstein R. Trigeminohypothalanric and reticulohypothalanric tract neurons in the upper cervical spinal cord and caudal medulla of the rat // J. Neurophysiol. 2000. Vol. 84. P. 2078-2112.
  89. Matharu M.S., Goadsby P.J. Persistence of attacks of cluster headache after trigeminal nerve root section // Brain. 2002. Vol. 125. P. 976-984.
  90. Mauskop A. Vagus nerve stimulation relieves chronic refractory migraine and cluster headaches // Cephalalgia. 2005. Vol. 25. P.82-86.
  91. Mauskop A. The Use of Botulinum Toxin in the Treatment of Headaches // Pain Physician. 2004. Vol. 7. P. 377-387.
  92. May A. Cluster headache: pathogenesis, diagnosis, and management//Lancet. 2005. Vol. 366. P. 843-855.
  93. Messlinger K. Migraine: where and how does the pain originate? // Exp. Brain Res. 2009. Vol. 196. № 1. P. 179-193.
  94. Messlinger K., Burstein R. Anatomy of central nervous system pathways related to head pain // The headaches. Williams & Wilkins, Philadelphia, 2000. P. 77-86.
  95. Messlinger K., Ellrich J. Meningeal nociception: electrophysiological studies related to headache and referred pain // Microsc. Res. Tech. 2001. Vol. 53. P. 129-137.
  96. Milanov I., Bogdanova D. Trigenrino-cervical reflex in patients with headache // Cephalalgia. 2003. Vol. 23. P. 35-38.
  97. Miskov S. Neurophysiological methods in headache diagnosis //Acta Med. Croatica. 2008. Vol. 62. № 2. P. 189-196.
  98. Mitrirattanakul S., Merrill R.L. Headache impact in patients with orofacial pain // J. Am. Dent. Ass. 2006. Vol. 137. №9. P. 1267-1274.
  99. Mitsikostas D.D., Sanchez del Rio M. Receptor systems mediating c-fos expression within trigeminal nucleus caudalis in animal models of migraine // Brain Res. Rev. 2001. Vol. 35. P 20-35.
  100. Morch C.D., Hu J.W., Arendt-Nielsen L., Sessle B.J. Convergence of cutaneous, musculoskeletal, dural and visceral afferents onto nociceptive neurons in the first cervical dorsal horn // Eur. J. Neurosci. 2007. Vol. 26. № l.P. 142-154.
  101. Moskowitz M.A. Basic mechanisms in vascular headache //Neurol. Clin. 1990. Vol. 8. P. 801-815.
  102. Nardone R., Ausserer H., Bratti A. et al. Trigemino- cervical reflex abnonnalities in patients with migraine and cluster headache // Headache. 2008. Vol. 48. P. 578-585.
  103. Nardone R., Tezzon F. The trigemino-cervical reflex in tension-type headache // Eur. J. Neurol. 2003. Vol. 10. №3. P.307-312.
  104. Nixdorf D.R., Velly A.M., Alonso A.A. Neurovascular pains: implications of migraine for the oral and maxillofacial surgeon//Oral. Maxillofac. Surg. Clin. North. Am. 2008. Vol. 20. P. 221.
  105. Noseda R., Monconduit L., Constandil L. et al. Central nervous system networks involved in the processing of meningeal and cutaneous inputs from the ophthalmic branch of the trigeminal nerve in the rat // Cephalalgia. 2008. Vol. 28. P. 813-824.
  106. Olesen J. The international classification of headache disorders, 2nd ed. // Cephalagia. 2004. Vol. 24 (Suppl. 1). P. 1-160.
  107. Pajot J., Pelissier T., Sierralta F. et al. Differential effects of trigeminal tractotomy on Adelta- and Cfibermediated nociceptive responses // Brain Res. 2000. Vol. 863. P 289-292.
  108. Pan Y.Z., Pan H.L. Primary afferent stimulation differentially potentiates excitatory and inhibitory inputs to spinal lamina II outer and inner neurons // J. Neurophysiol. 2004. Vol. 91. P. 2413-2421.
  109. Panfil C., Makowska A., Ellrich J. Brainstem and cervical spinal cord Fos immunoreactivity evoked by nerve growth factor injection into neck muscles in mice // Cephalalgia. 2006. Vol. 26. № 2. P. 128- 135.
  110. Panneton W.M., McCulloch P.F., Sun W. Trigemino- autonomic connections in the muskrat: the neural substrate for the diving response // Brain Res. 2000. Vol. 874. № l.P. 48-65.
  111. Peres M.F., Stiles M.A., Siow H.C. et al. Greater occipital nerve blockade for cluster headache // Cephalalgia. 2002. Vol. 22. P. 520-522.
  112. Pinto M.L., Heloisa H., Olyntho-Tokunaga V. et al. The interstitial system of the trigeminal spinal tract projects to the red nucleus in mice // Somatosens & Motor Res. 2007. Vol. 24. P. 221-225.
  113. Piovesan E.J., Kowacs P.A., Tatsui C.E. et al. Referred pain after painful stimulation of the greater occipital nerve in humans: evidence of convergence of cervical afferences on trigeminal nuclei // Cephalalgia. 2001. Vol. 21. P. 107-109.
  114. Piovesan E.J., Kowacs P.A., Oshinsky M.L. Convergence of cervical and trigeminal sensory afferents // Cuit. Pain Headache Rep. 2003. Vol. 7. P. 377-383.
  115. Piovesan E.J., Stani F.D., Kowacs P.A. et al. Massaging over the greater occipital nerve reduces the intensity of migraine attacks: evidence for inhibitory trigemino-cervical convergence mechanisms // Arq. Neuropsiquiatr. 2007. Vol. 65. P. 599-604.
  116. Robertson B.A., Moms M.E. The role of cervical dysfunction in migraine: a systematic review // Cephalalgia. 2008. Vol. 28. № 5. P. 474-483.
  117. Saxon D.W., Hopkins D.A. Efferent and collateral organization of paratrigeminal nucleus projections: an anterograde and retrograde fluorescent tracer study in the rat // J. Comp. Neurol. 1998. Vol. 402. № 1. P. 93- 110.
  118. Saxon D.W., Hopkins D.A. Ultrastructure and synaptology of the paratrigeminal nucleus in the rat: primary pharyngeal and laryngeal afferent projections // Synapse. 2006. Vol. 59. P. 220-234.
  119. Schaller B. Trigeminocardiac reflex. A clinical phenomenon or a new physiological entity? // J Neurol. 2004. Vol. 251. № 6. P.658-665.
  120. Schepelmann K., Ebersberger A., Pawlak M. et al. Response properties of trigeminal brain stem neurons with input from dura mater encephali in the rat //Neuroscience. 1999. Vol.90. P.543-554.
  121. Schurks M., Diener H.C. Migraine, allodynia, and implications for treatment // Eur. J. Neurol. 2008. Vol. 15. P. 1279-1285.
  122. Serrao M., Perrotta A., Bartolo M. et al. Trigemino- cervical-spinal reflexes in humans // Clin. Neurophysiol. 2003. Vol. 114. № 9. P. 1697-1703.
  123. Sessle B.J. Acute & chronic craniofacial pain: bransteim mechanisms of nociceptive transmission etc // Crit. Rev. Oral. Biol. Med. 2000. Vol. 11. № 1. P. 57-91.
  124. Sessle B.J. Recent insights into brainstem mechanisms underlying craniofacial pain // J. Dent. Educ. 2002. Vol. 66. № l.P. 108-112.
  125. Shields K.G., Goadsby P.J. Propranolol modulates trigeminovascular responses in thalamic VPM nucleus: a role in migraine? // Brain. 2005. Vol. 128. P. 86-97.
  126. Silberstein S.D. Migraine // Lancet. 2004. Vol. 363. P. 381-391.
  127. Strassman A.M., Levy D. Response Properties of Dural Nociceptors in Relation to Headache // J. Neurophysiol. 2006. Vol. 95. P. 1298-1306.
  128. Strassman A.M., Weissner W., Williams M. et al. Axon diameters and intradural trajectories of the dural innervation in the rat // J. Comp. Neurol. 2004. Vol. 473. P. 364-376.
  129. Takemura M., Sugiyo S., Moritani M. et al. Mechanisms of orofacial pain control in the CNS // Arch. Histol. Cytol. 2006. Vol. 69. № 2. P. 79-100.
  130. Tanimoto T., Takeda M., Matsumoto S. Suppressive effect of vagal afferents on cervical dorsal horn neurons responding to tooth pulp electrical stimulation in the rat // Exp. Brain Res. 2002. Vol. 145. № 4. P. 468-479.
  131. Theoharides Т.С., Donelan J., Kandere-Grzybowska К. et al. The role of mast cells in migraine pathophysiology // Brain Res. Rev. 2005. Vol. 49. P. 65-76.
  132. Ter Horst G.J., Meijler W.J., Korf J. et al. Trigeminal nociception-induced cerebral Fos expression in the conscious rat// Cephalalgia. 2001. Vol. 21. № 10. P. 963-975.
  133. Tzvetanov R, RousseffR.T., Radionova Z.Abnormalities of masseter inhibitory reflex in patients with episodic tension-type headache // J. Zhejiang Univ. Sci. 2009. Vol. 10. №1. P.52-56.
  134. Voisin D.L., Domejean-Orliaguet S., Chalus M. et al. Ascending connections from the caudal part to the oral part of the spinal trigeminal nucleus in the rat // Neurosci. 2002. Vol. 109. № 1. P. 183-193.
  135. Wang N., May P.J. Peripheral muscle targets and central projections of the mesencephalic trigeminal nucleus in macaque monkeys // Anat. Rec. 2008. Vol. 291. №8. P.974-987
  136. Ward T.N., Levin M. Case reports: headache caused by a spinal cord stimulator in the upper cervical spine // Headache.2000. Vol. 40. № 8. P 689-691.
  137. Woda A. Pain in the Trigeminal System: from Orofacial Nociception to Neural Network Modeling // J. Dent. Res. 2003. Vol. 82. № 10. P 764-768.
  138. Woolf C.J., Ma Q. Nociceptors - noxious stimulus detectors // Neuron. 2007. Vol. 55. P. 353-364.
  139. Yamamura FI., MaliclcA., Chamberlin N.L. et al. Cardiovascular and neuronal responses to head stimulation reflect central sensitization and cutaneous allodynia in a rat model of migraine // J. Neurophysiol. 1999. Vol. 81. №2. P. 479-493.
  140. Yamitslcy D., Goor-Aryeh I., BajvvaZ.H. etal. Wolff Award: possible parasympathetic contributions to peripheral and central sensitization during migraine // Headache. 2003. Vol. 43. P. 704-714.
  141. Zerari-Mailly F., Dauvergne C., Buisseret P, Buisser- et-Delmas C. Localization of trigeminal, spinal and reticular neurons involved in the rat blink reflex // J. Comp. Neurol. 2003. Vol. 467. P. 173-184.
  142. Zerari-Mailly E, Pinganaud G., Dauvergne C. et al. Trigemino-reticulo-facial and trigemino-reticulo- hypoglossal pathways in the rat // J. Comp. Neurol. 2001. Vol. 429. P.80-93.
  143. Zerari-Mailly F., Buisseret P, Buisseret-Delmas C., Nosjean A. Trigemino-solitarii-facial pathway in rats // J. Comp. Neurol. 2005. Vol. 487. P. 176-189.
  144. Zhang L.L., Ashwell K.W. The development of cranial nerve and visceral afferents to the nucleus of the solitary tract in the rat // Anat. Embryol. 2001. Vol. 204. №2. P. 135-151.

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