The influence of different doses of isoniazid at the time of sputum smear conversion among patients with drug-sensitive pulmonary tuberculosis


The main aim of our study was to estimate the influence of different doses of isoniazid 5 and 10 mg/kg in the combination with the other antituberculosis drugs at the time of sputum smear conversion among patients with drug-sensitive pulmonary tuberculosis. We carried out cohort prospective study of 77 patients with new cases of tuberculosis or relapse. The patients received treatment in the 3 department of the Regional Clinical ТВ Dispensary, Arkhangelsk, since April, 2008 till Aprill, 2009. A comparative analysis on 2 regimens of antituberculosis treatment was carried out. It included: rifampicin (10 mg/kg), pirazinamid (30 mg/kg), etambutol (25 mg/kg) and isoniazid 5 mg/kg (group 1) or 10 mg/kg (group 2). At the end of the intensive phase of treatment intoxication and clinical manifestations disappeared in all the patients of group 1 and group 2. The mean time from the initiation of appropriate therapy to sputum smear conversion in two groups were approximately the same (Me=3,00, Q1=1,00, Q3=8,50 и Me=3,00, Q1=1,00, Q3=7,00).The patients from group 1 and group 2 had the same rates of sputum smear conversion at the 1 week (RR=0,938, 95%Ci=0,468-1,635) and at the 1 month of treatment (RR=1,036, 95%CI=0,741-1,447). By the end of the intensive phase (3 month) 35 (79,8%) patients from groupl and 30 (90,9%) patients of group 2 have converted by smear (RR=0,875,95%C1=0,727-1,052). By the end of intensive phase all patients reached sputum culture conversion and had positive radiological changes. The patients in both groups, where different doses of isoniazid (5 and 10 mg/kg) in the combination with other antituberculosis drugs were used, demonstrated a high effectiveness of treatment. No statistically significant differences in the time of sputum smear conversion in both groups were found.

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  1. Браженко Н.А., Браженко О.Н. Фтизиопульмонология. М.: Академия, 2006. С. 266-267.
  2. Васильев А.В. Современные проблемы туберкулеза в регионе Северо-Запада России // Пробл. туб. 1999. №3. С. 5-7.
  3. Визель А.А., Гурылева М.Э.Туберкулез. М., 1999. С. 281-284.
  4. Мишин В.Ю., Стрелис А.К., Чуканов В.И. и др. Лекции по фтизиопульмонологии. М.: ООО «Медицинское информационное агентство», 2006. С. 230-232.
  5. Перельман М.И., Корякин В.А., Богадельникова И.В. М.: Медицина, 2004. С. 426^127.
  6. Приказ Министерства здравоохранения и социального развития от 21 марта 2003 года № 109 «О совершенствовании противотуберкулезных мероприятий в Российской Федерации». М., 2003.
  7. Brindle R., Odhiambo J., Mitchison D. Serial counts of Mycobacterium tuberculosis in sputum as surrogate markers of the sterilizing activity of rifampicin and pyrazinamide in treating pulmonary tuberculosis // BMC Pulm. Med. 2001. Vol. P. 2-8.
  8. Dominguez-Castellano A., Muniain M.A., Rodriguez- Bano J. et al. Factors associated with time to sputum smear conversion in active pulmonary tuberculosis // Int. J. tuberc. Lung. Dis. Vol. 7. № 5. P. 432-436.
  9. Donald P.R., Sirgel F.A., Botha F.J. et al. The early bactericidal activity of isoniazid related to its dose size in pulmonary tuberculosis // Am. J. Respir. Crit. Care Med. 1997. Vol. 156. P. 895-900.
  10. Global Tuberculosis Control. Surveillance, Planning, Financing. WHO report 2005 // World Plealth Organization. Geneva, 2005.
  11. Jindai A., Aber V.R., Edwards E.A., Mitchinson D.A. The early bactericidal activity of drugs in patients with pulmonary tuberculosis // Am. Rev. Respir. Dis. 1980. Vol. 121. P. 939-949.
  12. Masako WADA, Takashi Yoshiyama, Hideo Ogata. Six-months chemotherapy (2HRZS or E/4FIRE) of new cases of pulmonary tuberculosis // Kekkaku. 1999. Vol. 74. № 4. P. 353-360.
  13. Mitchison D.A. Role of individual drugs in the chemotherapy of tuberculosis // Int. J. Tuberc. Lung. Dis. 2000. Vol. 4. № 9. P. 796-806.
  14. Rider H.L. Intervention for Tuberculosis Control and Elimination. International Union Against Tuberculosis and Lung Disease, 2002.
  15. TelzakE.E., Fazal B.A., Pollard C.L. et al. Factors influencing time to sputum conversion among patients with smear-positive pulmonary tuberculosis // Clin. Infect. Dis. 1997. Vol. 25. P. 666-670.



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